BI-847325
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- CAS号:
- 1207293-36-4
- 英文名:
- BI-847325
- 英文别名:
- BI-847325;BI 847325;BI847325;BI-847325;BI 847325;BI847325;BI-847325, 98%, an ATP competitive dual inhibitor of MEK and aurora kinases (AK);3-[3-[[4-(dimethylaminomethyl)anilino]-phenylmethylidene]-2-oxo-1H-indol-6-yl]-N-ethylprop-2-ynamide;3-(3-(((4-((Dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindolin-6-yl)-N-ethylpropiolamide;(Z)-3-(3-(((4-((Dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindolin-6-yl)-N-ethylpropiolamide;3-[3-[[[4-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indol-6-yl]-N-ethyl-2-propynamide;2-Propynamide, 3-[3-[[[4-[(dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indol-6-yl]-N-ethyl-;BI 847325,inhibit,Apoptosis,MEK,MAPKK,MAP2K,Inhibitor,Aurora Kinase,Mitogen-activated protein kinase kinase,BI847325,BI-847325
- 中文名:
- BI-847325
- 中文别名:
- MEK和极光激酶(AK)双重抑制剂(BI-847325);BI-847325, MEK 和极光激酶 (AK)的ATP竞争性双重抑制剂;3-(3-(((4-((二甲氨基)甲基)苯基)氨基)(苯基)亚甲基)-2-氧代吲哚-6-基)-N-乙基丙酰胺
- CBNumber:
- CB12743902
- 分子式:
- C29H28N4O2
- 分子量:
- 464.56
- MOL File:
- 1207293-36-4.mol
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BI-847325化学性质
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储存条件:
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Store at -20°C
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溶解度:
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≥24.1 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
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形态:
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crystalline solid
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BI-847325性质、用途与生产工艺
BI-847325是一种口服具有生物活性的选择性的双重MEK/Aurora kinase抑制剂，对非洲爪蟾Aurora B，人Aurora A 和Aurora C，以及人MEK1 和MEK2的IC50分别为3 nM，25 nM，15 nM，25 nM，和4 nM。Phase 1。
| Target | Value |
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Aurora B (Xenopus laevis)
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3 nM
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MEK2
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4 nM
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Aurora C (Human)
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15 nM
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Aurora A (Human)
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25 nM
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MEK1
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25 nM
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BI-847325对BRAF突变型和vemurafenib耐药的黑色素瘤细胞表现出生长抑制作用，IC50 范围为0.3 nM-2 μM，并防止6个BRAF突变型黑色素瘤细胞系中集落形成。BI-847325也会通过减少Mcl-1表达诱导细胞凋亡。
在负荷1205Lu和1205LuR异种移植物的小鼠中，BI-847325 (75 mg/kg, p.o.)引起显著的肿瘤退化，而不显著改变体重。
BI-847325
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-18955 | BI-847325 | | 1 mg | 500元 |
| 2024/01/25 | HY-18955 | BI-847325
BI-847325 | 1207293-36-4 | 5mg | 1100元 |
1207293-36-4, BI-847325 相关搜索:
- APIs
- 药靶配体
- 抑制剂
- 细胞生物学试剂
- 3-(3-(((4-((二甲氨基)甲基)苯基)氨基)(苯基)亚甲基)-2-氧代吲哚-6-基)-N-乙基丙酰胺
- BI-847325, MEK 和极光激酶 (AK)的ATP竞争性双重抑制剂
- MEK和极光激酶(AK)双重抑制剂(BI-847325)
- 1207293-36-4
- BI 847325,inhibit,Apoptosis,MEK,MAPKK,MAP2K,Inhibitor,Aurora Kinase,Mitogen-activated protein kinase kinase,BI847325,BI-847325
- 3-(3-(((4-((Dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindolin-6-yl)-N-ethylpropiolamide
- 2-Propynamide, 3-[3-[[[4-[(dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indol-6-yl]-N-ethyl-
- (Z)-3-(3-(((4-((Dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindolin-6-yl)-N-ethylpropiolamide
- BI-847325;BI 847325;BI847325
- BI 847325;BI847325
- 3-[3-[[4-(dimethylaminomethyl)anilino]-phenylmethylidene]-2-oxo-1H-indol-6-yl]-N-ethylprop-2-ynamide
- BI-847325, 98%, an ATP competitive dual inhibitor of MEK and aurora kinases (AK)
- 3-[3-[[[4-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indol-6-yl]-N-ethyl-2-propynamide
- BI-847325