化合物 T13099
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- CAS号:
- 1005775-56-3
- 英文名:
- TC ASK 10
- 英文别名:
- TC ASK 10;ASK1 Inhibitor 10;4-tert-butyl-N-(6-imidazol-1-ylimidazo[1,2-a]pyridin-2-yl)benzamide:hydrochloride;4-(1,1-Dimethylethyl)-N-[6-(1H-imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl]benzamide dihydrochloride;Apoptosis,ASK1,oral,MAP3K,bioavailability,TC ASK-10,TC ASK10,Inhibitor,pharmacokinetic,JNK,TC ASK 10,p38,inhibit,selective,MAP kinase kinase kinase, MEKK, MAPKKK,Phosphorylation
- 中文名:
- 化合物 T13099
- 中文别名:
- 化合物 T13099;化合物TC ASK 10
- CBNumber:
- CB13037545
- 分子式:
- C21H22ClN5O
- 分子量:
- 395.89
- MOL File:
- 1005775-56-3.mol
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化合物 T13099化学性质
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熔点:
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>270° (dec.)
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储存条件:
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Refrigerator, under inert atmosphere
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溶解度:
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DMSO (Slightly), Methanol (Slightly)
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形态:
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Solid
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颜色:
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White to Off-White
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化合物 T13099性质、用途与生产工艺
TC ASK 10 (Compound 10) 是一种有效的,选择性的,口服活性的细胞凋亡信号调节激酶 1 (ASK1) 抑制剂,IC50 为 14 nM。TC ASK 10 对其他代表性激酶的抑制活性低于 50%,ASK2 除外 (IC50 为 0.51 μM)。
TC ASK 10 (Compound 10; 0-10 μM; 1 hour; INS-1 cells) treatment inhibits streptozotocin (STZ)-induced JNK in INS-1 pancreatic β cells from 0.3 μM. Phosphorylation of p38 is also inhibited in a dosedependent manner.
Western Blot Analysis
Cell Line:
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INS-1 cells
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Concentration:
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0 μM, 0.3 μM, 1 μM, 3 μM, 10 μM
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Incubation Time:
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1 hour
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Result:
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Was found to inhibit streptozotocin (STZ)-induced JNK in INS-1 pancreatic β cells from 0.3 μM. Phosphorylation of p38 was also inhibited in a dosedependent manner.
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Pharmacokinetic profiles in rats are tested. TC ASK 10 (Compound 10•HCl; rat cassette doing at 0.1 mg/kg, iv and 1 mg/kg, po.) has a good oral bioavailability. The C
max
, T
max
and AUC
po,0-8h
are 285.1 ng/mL, 1.67 h and 275.4 ng.h/mL, respectively for TC ASK 10.
化合物 T13099
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/01/25 | HY-103258 | TC ASK 10 | | 1 mg | 1333元 |
2024/01/25 | HY-103258 | 化合物 T13099 TC ASK 10 | 1005775-56-3 | 5mg | 3850元 |
1005775-56-3, 化合物 T13099 相关搜索:
- C21H21N5O2HCl
- 化合物TC ASK 10
- 化合物 T13099
- 1005775-56-3
- Apoptosis,ASK1,oral,MAP3K,bioavailability,TC ASK-10,TC ASK10,Inhibitor,pharmacokinetic,JNK,TC ASK 10,p38,inhibit,selective,MAP kinase kinase kinase, MEKK, MAPKKK,Phosphorylation
- 4-(1,1-Dimethylethyl)-N-[6-(1H-imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl]benzamide dihydrochloride
- 4-tert-butyl-N-(6-imidazol-1-ylimidazo[1,2-a]pyridin-2-yl)benzamide:hydrochloride
- ASK1 Inhibitor 10
- TC ASK 10