1189561-66-7
|
|
|
- CAS号:
- 1189561-66-7
- 英文名:
- (S)-Gossypol (acetic acid)
- 英文别名:
- (S)-Gossypol (acetic acid)
- 中文名:
- 1189561-66-7
- 中文别名:
- BCL-2抑制剂((S)-GOSSYPOL ACETIC ACID)
- CBNumber:
- CB13041379
- 分子式:
- C32H34O10
- 分子量:
- 578.61
- MOL File:
- 1189561-66-7.mol
|
|
|
1189561-66-7化学性质
-
储存条件:
-
Store at -20°C, protect from light, stored under nitrogen
-
|
-
溶解度:
-
DMSO: 50 mg/mL (86.41 mM); Water: < 0.1 mg/mL (insoluble)
-
|
1189561-66-7性质、用途与生产工艺
(S)-Gossypol acetic acid 是天然产物 Gossypol 的异构体。(S)-Gossypol 以高亲和力结合到 Bcl-xL 和 Bcl-2 蛋白的 BH3 结合沟。
The natural racemic Gossypol has two enantiomers, namely the (-)-Gossypol and (S)-Gossypol ((+)-Gossypol) enantiomers. (+)-Gossypol and (-)-Gossypol binds to Bcl-2 or Bcl-xL with similar binding affinities. (-)-Gossypol is more potent than (+)-Gossypol in inhibition of cell growth and induction of apoptosis. The racemic form and each of the enantiomers of Gossypol are tested against UM-SCC-6 and UM-SCC-14A in 6-day MTT assays. (-)-Gossypol exhibits greater growth inhibition relative to (±)-Gossypol than (+)-Gossypol in both cell lines tested (P<0.001). An intermediate growth inhibitory effect is observed with (±)-Gossypol but this effect is only observed at the higher dose of Gossypol (10 μM, P<0.0001).
1189561-66-7
上下游产品信息
上游原料
下游产品
6,6′,7,7′-四羟基-5,5′-二异丙基-3,3′-二甲基-(2,2′-联萘)-1,1′,4,4′-四酮-8,8′-二甲醛
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-15464D | (S)-Gossypol (acetic acid) | | 5 mg | 875元 |
| 2024/01/25 | HY-15464D | 1189561-66-7
(S)-Gossypol (acetic acid) | 1189561-66-7 | 10mg | 1400元 |
1189561-66-7, 1189561-66-7 相关搜索:
- 抑制剂
- 细胞生物学试剂
- BCL-2抑制剂((S)-GOSSYPOL ACETIC ACID)
- 1189561-66-7
- (S)-Gossypol (acetic acid)