833481-73-5
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- CAS号:
- 833481-73-5
- 英文名:
- 2OH-BNPP1
- 英文别名:
- 2OH-BNNP;2OH-BNPP1;inhibit,2OH BNPP1,2OH-BNPP-1,Inhibitor,2OHBNPP1,2OH-BNPP1;2-((4-Amino-1-(tert-butyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)methyl)phenol;Phenol, 2-[[4-amino-1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]methyl]-
- 中文名:
- 833481-73-5
- 中文别名:
- 化合物2OH-BNPP1;BUB1KINASE抑制剂(2OH-BNPP1)
- CBNumber:
- CB13110453
- 分子式:
- C16H19N5O
- 分子量:
- 297.36
- MOL File:
- 833481-73-5.mol
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833481-73-5化学性质
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储存条件:
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Store at -20°C
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溶解度:
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DMSO : ≥ 100 mg/mL (336.30 mM)
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833481-73-5性质、用途与生产工艺
2OH-BNPP1 是一种 BUB1 kinase 抑制剂，可用于癌症研究。
2OH-BNPP1 (0.1-50 μM) abrogates TGFβ signaling in a dose dependent manner. 2OH-BNPP1 dose-dependently impairs the TGFβ-induced phosphorylation of proteins that mediate canonical and non-canonical TGFβ signaling in multiple cancer cell lines and normal cell lines.
2OH-BNPP1 (50 mg/kg) blocks TGFβ signaling in vivo, and significantly decreases abundance of phosphorylated SMAD2 in tumor-bearing mice.
833481-73-5
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-102081 | 833481-73-5
2OH-BNPP1 | 833481-73-5 | 2mg | 1000元 |
| 2024/01/25 | HY-102081 | 833481-73-5
2OH-BNPP1 | 833481-73-5 | 10mM * 1mLin DMSO | 1635元 |
833481-73-5, 833481-73-5 相关搜索:
- 制剂-抑制剂
- 细胞生物学试剂
- 化合物2OH-BNPP1
- BUB1KINASE抑制剂(2OH-BNPP1)
- 833481-73-5
- inhibit,2OH BNPP1,2OH-BNPP-1,Inhibitor,2OHBNPP1,2OH-BNPP1
- 2OH-BNNP
- Phenol, 2-[[4-amino-1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]methyl]-
- 2-((4-Amino-1-(tert-butyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)methyl)phenol
- 2OH-BNPP1