AM2394
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- CAS号:
- 1442684-77-6
- 英文名:
- AM2394
- 英文别名:
- AM2394;CS-2242;AM2394;AM 2394;AM-2394,Hexokinase D,Inhibitor,AM 2394,Glucokinase,inhibit,Hexokinase IV;N-[6'-(2-Hydroxy-2-methylpropoxy)-4-[(5-methyl-3-pyridinyl)oxy][3,3'-bipyridin]-6-yl]-N'-methylurea;1-(6'-(2-hydroxy-2-methylpropoxy)-4-((5-methylpyridin-3-yl)oxy)-[3,3'-bipyridin]-6-yl)-3-methylurea;1-(6'-(2-Hydroxy-2-methylpropoxy)-4-((5-methylpyridin-3-yl)oxy)-[3,3'-bipyridin]-6-yl)-3-methylurea;Urea, N-[6'-(2-hydroxy-2-methylpropoxy)-4-[(5-methyl-3-pyridinyl)oxy][3,3'-bipyridin]-6-yl]-N'-methyl-
- 中文名:
- AM2394
- 中文别名:
- 化合物AM2394;AM-2394游离态;AM 2394,葡萄糖激酶激活剂;1-(6'-(2-羟基-2-甲基丙氧基)-4-((5-甲基吡啶-3-基)氧基)-[3,3'-联吡啶]-6-基)-3-甲基脲;1-(6'-(2-羟基-2-甲基丙氧基)-4-((5-甲基吡啶-3-基)氧基)-[3,3'-联吡啶]-6-基)-3-甲基脲
- CBNumber:
- CB13145987
- 分子式:
- C22H25N5O4
- 分子量:
- 423.46
- MOL File:
- 1442684-77-6.mol
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AM2394化学性质
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沸点:
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588.8±50.0 °C(Predicted)
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密度:
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1.266±0.06 g/cm3(Predicted)
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储存条件:
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Inert atmosphere,Room Temperature
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溶解度:
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DMF: 1 mg/ml; DMSO: 1 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.50 mg/ml
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形态:
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A crystalline solid
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酸度系数(pKa):
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12.66±0.70(Predicted)
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颜色:
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White to off-white
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AM2394性质、用途与生产工艺
AM 2394是一种结构独特的葡萄糖激酶激活剂(GKA)。AM-2394通过一个60 nM的EC50激活GK。
AM-2394 是一种新型的 glucokinase 激活剂 (GKA)。AM-2394激活葡萄糖激酶 (GK),EC50 为 60 nM。
EC50: 60 nM (glucokinase)
AM-2394, a structurally distinct glucokinase activator that displays a robust reduction in plasma glucose during an oral glucose tolerance test (OGTT) in
ob/ob
mice at a dose of 3 mg/kg. AM-2394 increases the affinity of glucokinase (GK) for glucose by approximately 10-fold, exhibits moderate clearance and good oral bioavailability in multiple animal models, and lowers glucose excursion following an oral glucose tolerance test in an
ob/ob
mouse model of diabetes. AM-2394 exhibits good-to-moderate cross species plasma clearance, volume of distribution, and oral bioavailability, allowing for further evaluation in animal models.
AM2394
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-100221 | AM2394 AM-2394 | 1442684-77-6 | 5mg | 750元 |
2024/08/19 | HY-100221 | AM-2394 | | 10 mM * 1 mLin DMSO | 825元 |
1442684-77-6, AM2394 相关搜索:
- API
- 化工试剂
- 酶
- 抑制剂
- AM 2394,葡萄糖激酶激活剂
- 1-(6'-(2-羟基-2-甲基丙氧基)-4-((5-甲基吡啶-3-基)氧基)-[3,3'-联吡啶]-6-基)-3-甲基脲
- 1-(6'-(2-羟基-2-甲基丙氧基)-4-((5-甲基吡啶-3-基)氧基)-[3,3'-联吡啶]-6-基)-3-甲基脲
- AM-2394游离态
- 化合物AM2394
- 1442684-77-6
- 1-(6'-(2-Hydroxy-2-methylpropoxy)-4-((5-methylpyridin-3-yl)oxy)-[3,3'-bipyridin]-6-yl)-3-methylurea
- AM-2394,Hexokinase D,Inhibitor,AM 2394,Glucokinase,inhibit,Hexokinase IV
- Urea, N-[6'-(2-hydroxy-2-methylpropoxy)-4-[(5-methyl-3-pyridinyl)oxy][3,3'-bipyridin]-6-yl]-N'-methyl-
- N-[6'-(2-Hydroxy-2-methylpropoxy)-4-[(5-methyl-3-pyridinyl)oxy][3,3'-bipyridin]-6-yl]-N'-methylurea
- CS-2242
- AM2394;AM 2394
- 1-(6'-(2-hydroxy-2-methylpropoxy)-4-((5-methylpyridin-3-yl)oxy)-[3,3'-bipyridin]-6-yl)-3-methylurea
- AM2394