1415925-18-6
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- CAS号:
- 1415925-18-6
- 英文名:
- GSK2795039
- 英文别名:
- GSK2795039;GSK-2795039
(GSK 2795039;Inhibitor,Reactive Oxygen Species,NADPH Oxidase,NOX,inhibit,Apoptosis,GSK-2795039,GSK2795039,GSK 2795039;N-(1-isopropyl-3-(1-methylindolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-methyl-1H-pyrazole-3-sulfonamide;1H-Pyrazole-3-sulfonamide, N-[3-(2,3-dihydro-1-methyl-1H-indol-6-yl)-1-(1-methylethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-methyl-
- 中文名:
- 1415925-18-6
- 中文别名:
- 化合物GSK2795039;NOX2抑制剂(GSK2795039);N-(1-异丙基-3-(1-甲基吲哚啉-6-基)-1H-吡咯[2,3-B]吡啶-4-基)-1-甲基-1H-吡唑-3-磺酰胺
- CBNumber:
- CB13152080
- 分子式:
- C23H26N6O2S
- 分子量:
- 450.56
- MOL File:
- 1415925-18-6.mol
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1415925-18-6化学性质
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沸点:
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691.5±65.0 °C(Predicted)
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密度:
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1.39±0.1 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMF:30.0(Max Conc. mg/mL);66.58(Max Conc. mM)
DMSO:66.27(Max Conc. mg/mL);147.07(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.44(Max Conc. mM)
Ethanol:20.0(Max Conc. mg/mL);44.39(Max Conc. mM)-
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形态:
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A solid
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酸度系数(pKa):
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6.99±0.30(Predicted)
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1415925-18-6性质、用途与生产工艺
GSK2795039 是 NADPH oxidase 2 (NOX2) 的抑制剂，对于NOX2介导的HRP/Amplex Red的激活的pIC50值为6.57。GSK2795039 可抑制活性氧reactive oxygen species (ROS)的产生，NADPH的消耗并减少细胞凋亡。
| Target | Value |
ROS
()
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NADPH
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NOX2 (HRP/Amplex Red)
(Cell-based assay)
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6.57(pIC50)
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GSK2795039 (25 μM; 24 hours) reduces the combinatory effect of FeSO4 and LPS-increased levels of apoptosis and reduced the presence of caspase-3-positive PC12 cells.
Apoptosis Analysis
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Cell Line:
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PC12 cells
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Concentration:
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25 μM
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Incubation Time:
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24 hours
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Result:
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Reduced apoptosis among PC12 cells.
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GSK2795039 (intraperitoneal injection; 100 mg/kg; 1 hour before) decreases activity in a murine model of acute pancreatitis, reducing the levels of serum amylase triggered by systemic injection of cerulein.
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Animal Model:
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C57BL6 mice
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Dosage:
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100 mg/kg
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Administration:
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Intraperitoneal injection; 100 mg/kg; 1 hour before
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Result:
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Caused 50% reduction in the level of serum amylase activity.
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1415925-18-6
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-18950 | GSK2795039 | | 1 mg | 1318元 |
| 2024/01/25 | HY-18950 | 1415925-18-6
GSK2795039 | 1415925-18-6 | 5mg | 2900元 |
1415925-18-6, 1415925-18-6 相关搜索:
- 药靶配体
- 细胞生物学试剂
- 抑制剂
- N-(1-异丙基-3-(1-甲基吲哚啉-6-基)-1H-吡咯[2,3-B]吡啶-4-基)-1-甲基-1H-吡唑-3-磺酰胺
- 化合物GSK2795039
- NOX2抑制剂(GSK2795039)
- 1415925-18-6
- Inhibitor,Reactive Oxygen Species,NADPH Oxidase,NOX,inhibit,Apoptosis,GSK-2795039,GSK2795039,GSK 2795039
- 1H-Pyrazole-3-sulfonamide, N-[3-(2,3-dihydro-1-methyl-1H-indol-6-yl)-1-(1-methylethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-methyl-
- GSK-2795039
(GSK 2795039
- N-(1-isopropyl-3-(1-methylindolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-methyl-1H-pyrazole-3-sulfonamide
- GSK2795039