172377-52-5
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- CAS号:
- 172377-52-5
- 英文名:
- Motolimod
- 英文别名:
- E2MATE;ES-J 995;BLE 00084;Estradiol Sulfamate;Estradiol 3-sulfamate;Estra-1,3,5(10)-triene-3,17-diol (17β)-, 3-sulfamate
- 中文名:
- 172377-52-5
- 中文别名:
- 化合物 T11235;雌二醇 3-氨基磺酸
- CBNumber:
- CB13159933
- 分子式:
- C18H25NO4S
- 分子量:
- 351.46
- MOL File:
- 172377-52-5.mol
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172377-52-5化学性质
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熔点:
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202-204 °C(Solv: methanol (67-56-1))
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沸点:
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531.1±60.0 °C(Predicted)
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密度:
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1.319±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 62.5 mg/mL (177.83 mM)
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酸度系数(pKa):
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8.88±0.70(Predicted)
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172377-52-5性质、用途与生产工艺
Estradiol 3-sulfamate (BLE 00084; E2MATE; ES-J 995) 是一种长效和有口服活性的类固醇硫酸酯酶 (steroid sulfatase) 抑制剂；抑制雌酮硫酸酯酶的 IC50 值为251 nM，Ki 值为133 nM。
IC50: 251 nM (estrone sulfatase)
Ki: 133 nM (estrone sulfatase)
Introduction of a fluoro, chloro, or bromo moiety at the C-2 position of EMATE and Estradiol 3-sulfamate and that of a fluoro moiety at the C-4 position of the parent sulfamates markedly increase the estrone sulfatase inhibitory activity.
Estradiol 3-sulfamate is readily transformed and absorbed in the gut into its oxidative metabolite, EMATE, and both compounds have already been shown to be potent, long-acting, and orally active STS inhibitors.
172377-52-5
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-U00112 | 172377-52-5
Estradiol 3-sulfamate | 172377-52-5 | 1mg | 2000元 |
| 2024/01/25 | HY-U00112 | 172377-52-5
Estradiol 3-sulfamate | 172377-52-5 | 10mM * 1mLin DMSO | 3093元 |
172377-52-5, 172377-52-5 相关搜索:
- 化合物 T11235
- 雌二醇 3-氨基磺酸
- 172377-52-5
- Estradiol Sulfamate
- Estra-1,3,5(10)-triene-3,17-diol (17β)-, 3-sulfamate
- ES-J 995
- E2MATE
- BLE 00084
- Estradiol 3-sulfamate