无中文名称
|
|
|
- CAS号:
- 1644388-26-0
- 英文名:
- EAD1 HCl
- 英文别名:
- EAD1 HCl;EAD1(free base);1,2-Ethanediamine, N1-[2-[[[1-[(4-chlorophenyl)methyl]-1H-1,2,3-triazol-4-yl]methyl]amino]ethyl]-N2-(7-chloro-4-quinolinyl)-N1-methyl-
- 中文名:
- 无中文名称
- 中文别名:
- CBNumber:
- CB13364065
- 分子式:
- C24H27Cl2N7
- 分子量:
- 484.42
- MOL File:
- 1644388-26-0.mol
|
|
|
无中文名称化学性质
-
沸点:
-
687.5±65.0 °C(Predicted)
-
|
-
密度:
-
1.31±0.1 g/cm3(Predicted)
-
|
-
酸度系数(pKa):
-
8.41±0.50(Predicted)
-
|
无中文名称性质、用途与生产工艺
EAD1 是一种有效的自噬 (autophagy) 抑制剂，在肺癌和胰腺癌细胞中具有抗增殖活性。EAD1 还诱导凋亡 (apoptosis)。
EAD1 (0-200 μM; 72 hours) has antiproliferative activity against human cancer cell lines.
EAD1 (5-75 μM; 24 hours) induces apoptosis in the H460 cells in a concentration-dependent manner.
EAD1 (1-25 μM; 24 hour) increases the punctate LC3 signal in H460 cells.
Cell Proliferation Assay
|
Cell Line:
|
H460 and HCC827 nonsmall cell lung cancer (NSCLC) and BxPC3 pancreatic cancer cells
|
|
Concentration:
|
0, 50, 100, 150, 200 μM
|
|
Incubation Time:
|
72 hours
|
|
Result:
|
IC
50
s of 11, 7.6, and 5.8 μM for H460, HCC827, and BxPC3 cells, respectively.
|
Apoptosis Analysis
|
Cell Line:
|
H460 cells
|
|
Concentration:
|
5, 25, 50, and 75 μM
|
|
Incubation Time:
|
24 hours
|
|
Result:
|
Induction of apoptosis.
|
Western Blot Analysis
|
Cell Line:
|
H460 cells
|
|
Concentration:
|
1, 2.5, 5, 10, 25 μM
|
|
Incubation Time:
|
24 hours
|
|
Result:
|
Caused concentration and time-dependent increases in LC3-II levels.
|
无中文名称
上下游产品信息
上游原料
下游产品
1644388-26-0, 无中文名称 相关搜索:
- C24H27Cl2N7
- 1644388-26-0
- 1,2-Ethanediamine, N1-[2-[[[1-[(4-chlorophenyl)methyl]-1H-1,2,3-triazol-4-yl]methyl]amino]ethyl]-N2-(7-chloro-4-quinolinyl)-N1-methyl-
- EAD1(free base)
- EAD1 HCl