腺苷高碘酸氧化物
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- CAS号:
- 34240-05-6
- 英文名:
- ADENOSINE, PERIODATE OXIDIZED
- 英文别名:
- AdenosineDialdehyde(ADOX);ADENOSINE-2',3'-DIALDEHYDE;periodate-oxidizedadenosine;ADENOSINE, PERIODATE OXIDIZED;Adenosine, periodate oxidized >=93%;2-(1-(6-aMino-9H-purin-9-yl)-2-oxoethoxy)-3-hydroxypropanal;Hydracrylaldehyde, 2-((6-amino-9H-purin-9-yl)formylmethoxy)-;9H-Purine-9-acetaldehyde, 6-amino-α-(1-formyl-2-hydroxyethoxy)-;alpha-(Hydroxymethyl)-alpha'-(6-aminopurin-9-yl)diglycolaldehyde;6-amino-alpha-(1-formyl-2-hydroxyethoxy)-9h-purine-9-acetaldehyd
- 中文名:
- 腺苷高碘酸氧化物
- 中文别名:
- 腺苷二醛;氧化高碘酸腺苷;腺苷高碘酸氧化物;PERFEMIKER]ADENOSINE DIALDEHYDE (ADOX),99%
- CBNumber:
- CB1348648
- 分子式:
- C10H11N5O4
- 分子量:
- 265.23
- MOL File:
- 34240-05-6.mol
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腺苷高碘酸氧化物化学性质
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沸点:
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532.9±60.0 °C(Predicted)
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密度:
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1.69±0.1 g/cm3(Predicted)
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储存条件:
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-20°C
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溶解度:
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Soluble in DMSO
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形态:
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powder
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酸度系数(pKa):
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13.72±0.10(Predicted)
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腺苷高碘酸氧化物性质、用途与生产工艺
Adenosine Dialdehyde (ADOX)是腺苷类似物，同时也是S-adenosylmethionine-dependent methyltransferase抑制剂，IC50为40 nM。
| Target | Value |
AdoHcy hydrolase
(Cell-free)
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40 nM
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Adenosine dialdehyde (AdOx)是一种间接抑制剂，可进入细胞内。AdOx抑制S-adenosyl-L-homocystein hydrolase，导致S-adenosyl-L-homo cystein (Adoicy)的积累。S-adenosyl-L-homo cystein (Adoicy)是甲基转移酶的抑制剂。AdOx抑制Tax激活的NF-κB通路，导致p53的重新激活以及诱导p53靶向基因的表达。AdOx可引起IκB激酶复合体的降解、通过稳定IκBα抑制NF-kB。在HTLV-1转化淋巴细胞中，AdOx诱导G2/M细胞周期阻滞和细胞死亡，对正常细胞无此作用。
AdOx可对小鼠神经母细胞瘤的原位生长具有有效抑制作用，延长携瘤小鼠的生命周期，但通过稳态输液途径给药时，AdOx并不抑制造血作用。AdOx抑制L1210白血病细胞的复制，当通过腹腔注射剂量为20 mg/kg/day的AdOx时，可延长约40%的生命周期。
腺苷高碘酸氧化物
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/16 | XW342405601 | 试剂Adenosine Dialdehyde (ADOX)
Adenosine Dialdehyde (ADOX) | | 25mg | 1692元 |
| 2023/10/26 | S8608 | 腺苷高碘酸氧化物
Adenosine Dialdehyde (ADOX) | 34240-05-6 | 5mg | 794.89元 |
34240-05-6, 腺苷高碘酸氧化物 相关搜索:
- Organic Building Blocks
- Oligonucleotides
- Nucleotides
- Nucleosides
- Chemical Synthesis
- Carbonyl Compounds
- C10-C12
- Building Blocks
- Biochemicals and Reagents
- Aldehydes
- 药靶配体
- 活性氧
- Nucleosides, Nucleotides, Oligonucleotides
- Nucleosides
- Biochemicals and Reagents
- BioChemical
- PERFEMIKER]ADENOSINE DIALDEHYDE (ADOX),99%
- 氧化高碘酸腺苷
- 腺苷二醛
- 腺苷高碘酸氧化物
- 34240-05-6
- AdenosineDialdehyde(ADOX)
- Adenosine, periodate oxidized >=93%
- 9H-Purine-9-acetaldehyde, 6-amino-α-(1-formyl-2-hydroxyethoxy)-
- periodate-oxidizedadenosine
- 6-amino-alpha-(1-formyl-2-hydroxyethoxy)-9h-purine-9-acetaldehyde
- 2-(1-(6-aMino-9H-purin-9-yl)-2-oxoethoxy)-3-hydroxypropanal
- 6-amino-alpha-(1-formyl-2-hydroxyethoxy)-9h-purine-9-acetaldehyd
- ADENOSINE-2',3'-DIALDEHYDE
- ADENOSINE, PERIODATE OXIDIZED
- Hydracrylaldehyde, 2-((6-amino-9H-purin-9-yl)formylmethoxy)-
- alpha-(Hydroxymethyl)-alpha'-(6-aminopurin-9-yl)diglycolaldehyde
- 9H-Purine-9-acetaldehyde, 6-amino-alpha-(1-formyl-2-hydroxyethoxy)-