2-氨基-2-去甲菠烷羧酸
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- CAS号:
- 20448-79-7
- 英文名:
- 2-AMINO-2-NORBORNANECARBOXYLIC ACID
- 英文别名:
- BCH;B-Bch;LAT1-IN-1;LAT1-IN-1 (BCH);2-AMINO-2-NORBORNANECARBOXYLIC ACID;2-Aminonorbornane-2-carboxylic acid;2-Amino-2-carboxy-bicyclo-2,2,1-heptane;2-AMINOBICYCLO[2.2.1]HEPTANE-2-CARBOXYLIC ACID;3-amino-3-bicyclo[2.2.1]heptanecarboxylic acid;3-aminobicyclo[2.2.1]heptane-3-carboxylic Acid
- 中文名:
- 2-氨基-2-去甲菠烷羧酸
- 中文别名:
- 2-氨基-2-二甲基降莰烷;2-氨基-2-去甲菠烷羧酸;2-氨基-2-去甲冰片羧酸;2-氨基二环[2.2.1]庚烷-2-羧酸;2-氨基双环[2.2.1]庚烷-2-羧酸
- CBNumber:
- CB1384309
- 分子式:
- C8H13NO2
- 分子量:
- 155.19
- MOL File:
- 20448-79-7.mol
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2-氨基-2-去甲菠烷羧酸化学性质
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熔点:
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>300 °C(lit.)
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沸点:
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295.5±23.0 °C(Predicted)
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密度:
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1.256±0.06 g/cm3(Predicted)
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储存条件:
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Keep in dark place,Sealed in dry,Room Temperature
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溶解度:
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Aqueous Acid (Slightly)
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形态:
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Solid
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酸度系数(pKa):
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2.58±0.20(Predicted)
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颜色:
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White
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水溶解性:
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Soluble to 100 mM in water
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CAS 数据库:
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20448-79-7(CAS DataBase Reference)
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2-氨基-2-去甲菠烷羧酸性质、用途与生产工艺
BCH (2-Aminobicyclo-(2,2,1)-heptane-2-carboxylic acid, LAT1-IN-1) 是一种选择性的、竞争性的 system L amino acid transporter 1 (LAT1)的抑制剂。BCH (LAT1-IN-1) 可在癌细胞中诱导凋亡。
LAT1-IN-1 (1-100 mM; 3 days; KYSE30 and KYSE150 esophageal cancer cells) treatment suppresses cell proliferation in a dose-dependent manner.
LAT1-IN-1 (30 mM; 24 and 48 hours; KYSE30 and KYSE150 cells) treatment significantly increases cell population in the G0/G1 phase in both KYSE30 and KYSE150 cells, indicating that LAT1-IN-1 induces cell cycle arrest at G1 phase.
LAT1-IN-1 (30 mM; 0-24 hours; KYSE30 and KYSE150 cells) treatment decreases phosphorylation of 4E-BP1 and p70S6K at 30 minutes and the decrease is continued for 24 hours. The amount of mTOR, 4E-BP1, and p70S6K proteins is slightly decreased.
Cell Proliferation Assay
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Cell Line:
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KYSE30 and KYSE150 esophageal cancer cells
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Concentration:
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1 mM, 3 mM, 5 mM, 10 mM, 20 mM, 30 mM, 40 mM, 50 mM, or 100 mM
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Incubation Time:
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3 days
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Result:
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Cell proliferation was suppressed in a dose-dependent manner.
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Cell Cycle Analysis
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Cell Line:
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KYSE30 and KYSE150 cells
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Concentration:
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30 mM
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Incubation Time:
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24 and 48 hours
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Result:
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Cell cycle arrest.
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Western Blot Analysis
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Cell Line:
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KYSE30 and KYSE150 cells
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Concentration:
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30 mM
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Incubation Time:
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0 hour, 0.5 hour, 1 hour, 3 hours, 6 hours, 24 hours
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Result:
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Phosphorylation of 4E-BP1 and p70S6K was decreased. The amount of mTOR, 4E-BP1, and p70S6K proteins was slightly decreased.
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LAT1-IN-1 (200 mg/kg; intravenous injection; daily; for 14 days; male BALB/c nude mice) treatment significantly delays tumor growth and decreases glucose metabolism, indicating that LAT1 inhibition potentially suppresses esophageal cancer growth in vivo.
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Animal Model:
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Male BALB/c nude mice (5-week-old) with KYSE150 cells
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Dosage:
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200 mg/kg
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Administration:
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Intravenous injection; daily; for 14 days
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Result:
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Significantly delayed tumor growth and decreased glucose metabolism.
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用途
氨基酸跨膜转运的抑制剂。
2-氨基-2-去甲菠烷羧酸
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/01/25 | HY-108540 | 2-氨基-2-去甲菠烷羧酸
LAT1-IN-1 | 20448-79-7 | 50mg | 600元 |
| 2024/01/25 | HY-108540 | 2-氨基-2-去甲菠烷羧酸
LAT1-IN-1 | 20448-79-7 | 10mM * 1mLin Water | 660元 |
20448-79-7, 2-氨基-2-去甲菠烷羧酸 相关搜索:
- 生化试剂
- Unnatural Amino Acid Derivatives
- Specialty Synthesis
- Others
- Peptide Synthesis
- Modified Amino Acids
- A - H
- Amino Acids and Peptides
- BioChemical
- Biochemicals and Reagents
- 2-氨基-2-去甲冰片羧酸
- 2-氨基二环[2.2.1]庚烷-2-羧酸
- 2-氨基双环[2.2.1]庚烷-2-羧酸
- 2-氨基-2-二甲基降莰烷
- 2-氨基-2-去甲菠烷羧酸
- 20448-79-7
- LAT-1-IN-1,inhibit,LAT1 IN 1,LAT1IN1,Apoptosis,Inhibitor
- 3-aminobicyclo[2.2.1]heptane-3-carboxylic Acid
- 3-amino-3-bicyclo[2.2.1]heptanecarboxylic acid
- LAT1-IN-1
- LAT1-IN-1 (BCH)
- 2-AMino-2-norbornanecarboxylic acid aMino acid transport inhibitor
- Bicyclo(2.2.1)heptane-2-carboxylic acid, 2-amino-
- B-Bch
- 2-Aminonorbornane-2-carboxylic acid
- 2-Amino-2-carboxy-bicyclo-2,2,1-heptane
- 2-AMINO-2-NORBORNANECARBOXYLIC ACID, 98% , MIXTURE OF ISOMERS
- BCH
- 2-AMINOBICYCLO[2.2.1]HEPTANE-2-CARBOXYLIC ACID
- 2-AMINO-2-NORBORNANECARBOXYLIC ACID