化合物 T25953
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- CAS号:
- 1177131-02-0
- 英文名:
- sodium (E)-4-((3-(4-nitrophenyl)-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)diazenyl)benzenesulfonate
- 英文别名:
- PHPS1 Na;PHPS1 Sodium;PHPS-1 Sodium,PHPS1 Sodium;sodium (E)-4-((3-(4-nitrophenyl)-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)diazenyl)benzenesulfonate
- 中文名:
- 化合物 T25953
- 中文别名:
- 化合物 T25953
- CBNumber:
- CB14107500
- 分子式:
- C21H16N5NaO6S
- 分子量:
- 489.44
- MOL File:
- 1177131-02-0.mol
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化合物 T25953性质、用途与生产工艺
PHPS1 sodium 是一种有效的选择性 Shp2 抑制剂，对 Shp2，Shp2-R362K，Shp1，PTP1B 和 PTP1B-Q 的 Ki 值分别为 0.73，5.8，10.7，5.8 和 0.47 μM。
Ki: 0.73 μM (Shp2), 5.8 μM (Shp2-R362K), 10.7 μM (Shp1), 5.8 μM (PTP1B), 0.47 μM (PTP1B-Q)
PHPS1 (30 μM; 6 days) inhibits proliferation of human tumor cells.
PHPS1 (5-20 μM; 5-360 minutes) inhibits Erk1/2 but not Akt and Stat3 phosphorylation in a dose-dependent manner.
Cell Viability Assay
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Cell Line:
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Human cancer cell lines MDA-MB-435, HCT-116 (colon carcinoma), HCT-15 (colon carcinoma), PC-3 (prostate carcinoma), HT-29 (colon carcinoma), NCI-H661 (lung carcinoma), and Caki-1 (kidney carcinoma)
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Concentration:
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30 μM
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Incubation Time:
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6 days
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Result:
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Resulted in a reduction in cell number of between 0% (Caki-1) to 74% (HT-29).
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Western Blot Analysis
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Cell Line:
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Madin-Darby canine kidney (MDCK) cells
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Concentration:
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5, 10, 20 μM
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Incubation Time:
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5, 15, 60, 120, 360 minutes
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Result:
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Inhibited HGF/SF (1 unit/mL)-induced phosphorylation and thus activation of Erk1/2 over a time period of 15 min to 6 h. In contrast, transient phosphorylation of Erk1/2 after 5 min was not affected.
Exhibited no effect on HGF/SF-induced activation of PI3K/Akt or Stat3.
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PHPS1 (3 mg/kg; i.p. injection; every day during the last week on the high-fat diet) renders Ldlr
-/-
mice less susceptible to atherosclerosis development.
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Animal Model:
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Ldlr
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(005061) mice
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Dosage:
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3 mg/kg
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Administration:
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Intraperitoneal (i.p.) injection; every day during the last week on the high-fat diet.
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Result:
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Revealed a significant decrease in atherosclerotic plaque size in the aorta compared with the other two groups.
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化合物 T25953
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-125108 | PHPS1 sodium | | 1 mg | 1727元 |
| 2024/04/30 | HY-125108 | 化合物 T25953
PHPS1 sodium | 1177131-02-0 | 5mg | 3800元 |
1177131-02-0, 化合物 T25953 相关搜索:
- 化合物 T25953
- 1177131-02-0
- PHPS-1 Sodium,PHPS1 Sodium
- PHPS1 Na
- PHPS1 Sodium
- sodium (E)-4-((3-(4-nitrophenyl)-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)diazenyl)benzenesulfonate