MW-150
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- CAS号:
- 1628502-91-9
- 英文名:
- MW-150
- 英文别名:
- MW-150;inhibit,MW 150,MW150,Autophagy,MW-150,p38 MAPK,Inhibitor;6-(4-Methylpiperazin-1-yl)-3-(naphthalen-2-yl)-4-(pyridin-4-yl)pyridazine;Pyridazine, 6-(4-methyl-1-piperazinyl)-3-(2-naphthalenyl)-4-(4-pyridinyl)-
- 中文名:
- MW-150
- 中文别名:
- 化合物MW-150;6-(4-甲基哌嗪-1-基)-3-(萘-2-基)-4-(吡啶-4-基)哒嗪
- CBNumber:
- CB14668247
- 分子式:
- C24H23N5
- 分子量:
- 381.47
- MOL File:
- 1628502-91-9.mol
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MW-150化学性质
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沸点:
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606.1±55.0 °C(Predicted)
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密度:
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1.202±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO : 40 mg/mL (104.86 mM; Need ultrasonic)
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形态:
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A solid
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酸度系数(pKa):
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7.16±0.42(Predicted)
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MW-150性质、用途与生产工艺
MW-150 (MW01-18-150SRM) 是一种选择性，口服有效的，可透过神经系统的 p38α MAPK 抑制剂，Ki 值为 101 nM。MW-150 抑制内源性 p38α MAPK 在活化的神经胶质中磷酸化内源性底物 MK2 的能力。
MW-150 (MW01-18-150SRM) 是一种选择性，口服有效的，可透过神经系统的 p38α MAPK 抑制剂，Ki 值为 101 nM。MW-150 抑制内源性 p38α MAPK 在活化的神经胶质中磷酸化内源性底物 MK2 的能力。
MW-150 inhibits in a concentration-dependent manner the ability of the endogenous p38α MAPK to phosphorylate an endogenous substrate MK2 in activated glia.
MW-150 blocks in a concentration-dependent manner the increased IL-1β production by activated glia. The IC
50
values are 332 nM and 936 nM for MK2 and IL-1β, respectively.
MW-150 (2.5 mg/kg; oral daily for 3-4 months) improves the APP/PS1 transgenic (Tg) mice performance in radial arm water maze (RAWM) and contextual fear conditioning tests.
MW-150 (2.5 mg/kg; given i.p.; daily for 14 days) treatment in APP
NLh/NLh
× PS
P264L/P264L
knock-in mouse (with no overexpression of the amyloid precursor protein) exhibits RAWM behavior indistinguishable from WT mice.
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Animal Model:
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APP/PS1 transgenic (Tg) mouse (overexpresses amyloid-beta)
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Dosage:
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2.5 mg/kg
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Administration:
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Oral daily; 3-4 months (until cognitive impairment is present)
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Result:
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Improved the Tg mice performance in radial arm water maze (RAWM) and contextual fear conditioning tests.
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MW-150
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-120111 | MW-150 | | 1 mg | 433元 |
| 2024/01/25 | HY-120111 | MW-150
MW-150 | 1628502-91-9 | 5mg | 1300元 |
1628502-91-9, MW-150 相关搜索:
- 合成有机化合物配体
- 6-(4-甲基哌嗪-1-基)-3-(萘-2-基)-4-(吡啶-4-基)哒嗪
- 化合物MW-150
- 1628502-91-9
- 6-(4-Methylpiperazin-1-yl)-3-(naphthalen-2-yl)-4-(pyridin-4-yl)pyridazine
- inhibit,MW 150,MW150,Autophagy,MW-150,p38 MAPK,Inhibitor
- Pyridazine, 6-(4-methyl-1-piperazinyl)-3-(2-naphthalenyl)-4-(4-pyridinyl)-
- MW-150