SU 9516
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- CAS号:
- 377090-84-1
- 英文名:
- SU 9516
- 英文别名:
- CS-1784;SU 9516;SU-9516;SU 9516 USP/EP/BP;3-(1H-imidazol-5-ylmethylidene)-5-methoxy-1H-indol-2-one;(Z)-3-((1H-iMidazol-4-yl)Methylene)-5-Methoxyindolin-2-one;3-(1H-Imidazol-4-ylmethylene)-5-methoxy-1,3-dihydro-indol-2-one;(Z)-1,3-Dihydro-3-(1H-imidazol-4-ylmethylene)-5-methoxy-2H-indol-2-one;(3Z)-1,3-Dihydro-3-(1H-imidazol-5-ylmethylene)-5-methoxy-2H-indol-2-one;2H-Indol-2-one, 1,3-dihydro-3-(1H-imidazol-5-ylmethylene)-5-methoxy-, (3Z)-;Apoptosis,Autophagy,SU-9516,SU 9516,SU9516,inhibit,CDK,Cyclin dependent kinase,Inhibitor
- 中文名:
- SU 9516
- 中文别名:
- 化合物SU9516;SU 9516,CYCLIN依赖性激酶(CDK)抑制剂;(Z)-3-((1H-咪唑-4-基)亚甲基)-5-甲氧基吲哚啉-2-酮
- CBNumber:
- CB1497100
- 分子式:
- C13H11N3O2
- 分子量:
- 241.25
- MOL File:
- 377090-84-1.mol
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SU 9516化学性质
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储存条件:
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Store at +4°C
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溶解度:
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DMSO: ~17 mg/mL
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形态:
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crystalline
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颜色:
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brown
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SU 9516性质、用途与生产工艺
SU9516是一种3位取代的吲哚酮类CDK抑制剂，对CDK2，CDK1，和CDK4的IC50分别为22 nM，40 nM，和200 nM。
SU9516 decreases cdk2-specific phosphorylation of the retinoblastoma protein pRB, increases caspase-3 activation, and alters cell cycle in RKO and SW480 cells. SU9516 also inhibits the cell proliferation, and induces cell apoptosis in both cell lines. SU9516 kills leukemic cells through inhibition of RNA Pol II CTD phosphorylation, oxidative damage and transcriptional down-regulation of Mcl-1. In human T-cell leukemia Jurkat cells, SU9516 significantly enhances sensitivity to methotrexate. In addition, SU9516 also suppresses Aurora-A centrosomal localization and consequent centrosome amplification.
SU9516是一种3位取代的吲哚酮类CDK抑制剂，对CDK2，CDK1，和CDK4的IC50分别为22 nM，40 nM，和200 nM。
| Target | Value |
CDK2
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22 nM
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CDK1
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40 nM
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CDK4
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200 nM
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在RKO和SW480细胞中，SU9516减小cdk2特定的视网膜细胞瘤蛋白pRB磷酸化作用， 增加胱天蛋白酶-3的活化作用，并改变细胞周期。SU9516也会抑制细胞系中细胞增殖，并诱导细胞凋亡。 SU9516通过抑制RNA Pol II CTD磷酸化，氧化性损伤以及Mcl-1的转录下调从而杀死白血病细胞。在人T细胞白血病Jurkat细胞，SU9516显著增强对甲氨蝶呤的敏感性。此外，SU9516也会抑制Aurora-A中心体定位和随后的中心体扩增。
SU 9516
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/16 | S7636 | SU 9516
SU9516 | 377090-84-1 | 5mg | 809.75元 |
| 2024/01/16 | S7636 | SU 9516
SU9516 | 377090-84-1 | 25mg | 2412.64元 |
377090-84-1, SU 9516 相关搜索:
- Serine/Threonine Kinase Inhibitors
- Protein Kinase Inhibitors
- Kinase/Phosphatase Biology
- Cyclin-Dependent Kinase (CDK)Cell Signaling and Neuroscience
- Cyclin Dependant Kinase 2Serine/Threonine Kinase Biology
- A to
- Inhibitors
- Intracellular Signaling
- Enzyme Inhibitors by Enzyme
- 药靶配体
- 小分子抑制剂，天然产物
- 抑制剂
- SU 9516,CYCLIN依赖性激酶(CDK)抑制剂
- (Z)-3-((1H-咪唑-4-基)亚甲基)-5-甲氧基吲哚啉-2-酮
- 化合物SU9516
- 377090-84-1
- Apoptosis,Autophagy,SU-9516,SU 9516,SU9516,inhibit,CDK,Cyclin dependent kinase,Inhibitor
- SU 9516 USP/EP/BP
- 2H-Indol-2-one, 1,3-dihydro-3-(1H-imidazol-5-ylmethylene)-5-methoxy-, (3Z)-
- SU 9516;SU-9516
- 3-(1H-imidazol-5-ylmethylidene)-5-methoxy-1H-indol-2-one
- CS-1784
- 3-(1H-Imidazol-4-ylmethylene)-5-methoxy-1,3-dihydro-indol-2-one
- (3Z)-1,3-Dihydro-3-(1H-imidazol-5-ylmethylene)-5-methoxy-2H-indol-2-one
- (Z)-1,3-Dihydro-3-(1H-imidazol-4-ylmethylene)-5-methoxy-2H-indol-2-one SU9516
- (Z)-3-((1H-iMidazol-4-yl)Methylene)-5-Methoxyindolin-2-one
- (Z)-1,3-Dihydro-3-(1H-imidazol-4-ylmethylene)-5-methoxy-2H-indol-2-one