CS-2367
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- CAS号:
- 292632-98-5
- 英文名:
- L-685 458
- 英文别名:
- CS-2367;L-685458 (L-685,458;L-685458;L 685458;L685458;(5S)-(tert-Butoxycarbonylamino)-6-phenyl-(4R)-hydroxy-(2R)-benzylhexanoyl)-L-leucy-L-phenylalaninamide;Apoptosis,alzheimer’s disease,L 685458,inhibit,L685458,HES1,cancer,Inhibitor,Gamma secretase,γ-secretase,L-685458;N-[(2R,4R,5S)-5-[[(1,1-DiMethylethoxy)carbonyl]aMino]-4-hydroxy-1-oxo-6- phenyl-2-(phenylMethyl)hexyl]-L-leucyl-L-phenylalaninaMide;L-Phenylalaninamide, N-[(2R,4R,5S)-5-[[(1,1-dimethylethoxy)carbonyl]amino]-4-hydroxy-1-oxo-6-phenyl-2-(phenylmethyl)hexyl]-L-leucyl-
- 中文名:
- CS-2367
- 中文别名:
- L-685458游离态;化合物L-685,458;((2S,3R,5R)-6-(((S)-1-(((S)-1-氨基-1-氧代-3-苯基丙-2-基)氨基)-4-甲基-1-氧代戊-2-基)氨基)-5-苄基-3-羟基-6-氧代-1-苯基己-2-基)氨基甲酸叔丁酯
- CBNumber:
- CB1503740
- 分子式:
- C39H52N4O6
- 分子量:
- 672.85
- MOL File:
- 292632-98-5.mol
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CS-2367化学性质
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熔点:
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212-213 °C
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沸点:
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938.5±65.0 °C(Predicted)
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密度:
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1.155±0.06 g/cm3(Predicted)
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储存条件:
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-20°C
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溶解度:
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DMSO: >10 mg/mL, soluble
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形态:
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solid
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酸度系数(pKa):
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12.09±0.46(Predicted)
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颜色:
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white
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CS-2367性质、用途与生产工艺
L-685,458 是一种beta PP gamma-secretase活性的特异性有效抑制剂,其Ki值为17 nM.。
Target | Value |
Gamma-secretase
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17 nM(Ki)
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在过表达人AβPP695的Neuro2A 和 CHO细胞系,以及过表达组成型spβA4CTF的SHSY5Y细胞中,L-685,458抑制Aβ(40)形成,IC50分别为402 nM,113 nM,和48 nM,减少Aβ(42)的效力大约低2倍。在Tca8113细胞中,L-685,458通过诱导G0–G1细胞周期阻滞和细胞凋亡,抑制细胞生长。在T细胞急性成淋巴细胞性白血病细胞系中,L-685,458预处理增强imatinib的抗增殖作用。 L685,458通过抑制信号肽酶(SPP),也会显著减少组织培养基中HSV-1复制。
L-685458 (percutaneous administration; 5 mg/kg; 2 weeks) has antitumor effects in mouse hepatoma models. L-685458 inhibits EpCAM production except in necrotic areas. And HES1 staining is also diminished in the nucleus.
Animal Model:
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NOD-SCID Mouse Hepatoma Model
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Dosage:
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5 mg/kg
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Administration:
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Percutaneous administration; 5 mg/kg; 2 weeks
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Result:
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Exhibited anti-tumor activities in vivo.
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CS-2367
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | S7673 | CS-2367 L-685,458 | 292632-98-5 | 1mg | 1599.07元 |
2024/08/19 | S7673 | CS-2367 L-685,458 | 292632-98-5 | 5mg | 5300.62元 |
292632-98-5, CS-2367 相关搜索:
- 药靶配体
- 抑制剂
- C39H52O6N4
- ((2S,3R,5R)-6-(((S)-1-(((S)-1-氨基-1-氧代-3-苯基丙-2-基)氨基)-4-甲基-1-氧代戊-2-基)氨基)-5-苄基-3-羟基-6-氧代-1-苯基己-2-基)氨基甲酸叔丁酯
- 化合物L-685,458
- L-685458游离态
- 292632-98-5
- Apoptosis,alzheimer’s disease,L 685458,inhibit,L685458,HES1,cancer,Inhibitor,Gamma secretase,γ-secretase,L-685458
- L-Phenylalaninamide, N-[(2R,4R,5S)-5-[[(1,1-dimethylethoxy)carbonyl]amino]-4-hydroxy-1-oxo-6-phenyl-2-(phenylmethyl)hexyl]-L-leucyl-
- L-685458;L 685458;L685458
- L-685458 (L-685,458
- CS-2367
- N-[(2R,4R,5S)-5-[[(1,1-DiMethylethoxy)carbonyl]aMino]-4-hydroxy-1-oxo-6- phenyl-2-(phenylMethyl)hexyl]-L-leucyl-L-phenylalaninaMide
- (5S)-(tert-Butoxycarbonylamino)-6-phenyl-(4R)-hydroxy-(2R)-benzylhexanoyl)-L-leucy-L-phenylalaninamide