Dot1L-IN-2
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- CAS号:
- 1940206-71-2
- 英文名:
- Dot1L-IN-2
- 英文别名:
- Dot1L-IN-2;Dot1L IN 2,Dot1LIN2,Dot-1L-IN-2;2,4-Pyrimidinediamine, N4-methyl-N2-[2-methyl-1-[2-[(3-methyl-3H-imidazo[4,5-b]pyridin-6-yl)oxy]phenyl]-1H-indol-6-yl]-
- 中文名:
- Dot1L-IN-2
- 中文别名:
- 化合物 T11082
- CBNumber:
- CB15821315
- 分子式:
- C27H24N8O
- 分子量:
- 476.53
- MOL File:
- 1940206-71-2.mol
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Dot1L-IN-2化学性质
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沸点:
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681.6±65.0 °C(Predicted)
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密度:
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1.36±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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6.81±0.10(Predicted)
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Dot1L-IN-2性质、用途与生产工艺
Dot1L-IN-2 是一种有效的,选择性的,可口服的 Dot1L (一种 histone methyltransferase),IC50 值和 Ki 值分别为 0.4 nM 和 0.08 nM。
IC50: 0.4 nM (Dot1L)
Ki: 0.08 nM (Dot1L)
Dot1L-IN-2 is a potent, selective Dot1L inhibitor, with an IC
50
and K
i
of 0.4 nM and 0.08 nM, respectively. Dot1L-IN-2 potently inhibits H3K79 dimethylation (IC
50
, 16 nM), and blocks the activity of the HoxA9 promoter (IC
50
, 340 nM) in cellular systems. Dot1L-IN-2 also dramatically suppresses proliferation of the human MLL-rearranged leukemia cell line MV4-11 carrying the oncogenic MLL-AF4 fusion (IC
50
, 128 nM).
Dot1L-IN-2
上下游产品信息
上游原料
下游产品
1940206-71-2, Dot1L-IN-2 相关搜索:
- 对照品
- 化合物 T11082
- 1940206-71-2
- Dot1L IN 2,Dot1LIN2,Dot-1L-IN-2
- 2,4-Pyrimidinediamine, N4-methyl-N2-[2-methyl-1-[2-[(3-methyl-3H-imidazo[4,5-b]pyridin-6-yl)oxy]phenyl]-1H-indol-6-yl]-
- Dot1L-IN-2