TYR-PRO-TRP-PHE-NH2
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- CAS号:
- 189388-22-5
- 英文名:
- ENDOMORPHIN-1
- 英文别名:
- YPWF-NH2;ENDOMORPHIN-1;TYR-PRO-TRP-PHE-NH2;H-TYR-PRO-TRP-PHE-NH2;Endomorphin 1, Endomorphin 1;ENDOMORPHIN-1 (HUMAN, BOVINE);L-Tyrosyl-L-prolyl-L-tryptophyl-L-phenylalaninamide;L-Phenylalaninamide,L-tyrosyl-L-prolyl-L-tryptophyl-;(2S)-1-[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]-N-[(1S)-1-[[(1S)-1-carbamoyl-2-phenyl-ethyl]carbamoyl]-2-(1H-indol-3-yl)ethyl]pyrrolidine-2-carboxamide;(2S)-1-[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]-N-[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]pyrrolidine-2-carboxamide
- 中文名:
- TYR-PRO-TRP-PHE-NH2
- 中文别名:
- 内吗啡 1;内吗啡肽 1;内吗啡肽 1、ENDOMORPHIN 1
- CBNumber:
- CB1684104
- 分子式:
- C34H38N6O5
- 分子量:
- 610.7
- MOL File:
- 189388-22-5.mol
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TYR-PRO-TRP-PHE-NH2化学性质
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熔点:
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144-146℃
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沸点:
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1052.8±65.0 °C(Predicted)
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密度:
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1.343±0.06 g/cm3(Predicted)
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RTECS号:
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SQ7316800
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储存条件:
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−20°C
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溶解度:
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≥14.9 mg/mL in H2O; ≥30.55 mg/mL in DMSO; ≥47 mg/mL in EtOH
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酸度系数(pKa):
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9.86±0.15(Predicted)
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形态:
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Solid
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颜色:
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White to off-white
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水溶解性:
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Soluble in water
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CAS 数据库:
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189388-22-5(CAS DataBase Reference)
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TYR-PRO-TRP-PHE-NH2性质、用途与生产工艺
Endomorphin 1，一种高度选择性的高亲和力μ-opioid受体激动剂 ， 对kappa3结合位点具有高亲和力 ，Ki为 20 到 30 nM 之间。
Ki: 20-30 nM (kappa
3
opioid receptor)
Endomorphin 1 (EM-1) is an endogenous opioid peptide and one of the two Endomorphins. It is a high affinity, highly selective agonist of the μ-opioid receptor, and along with Endomorphin 2 (EM-2). The two Endomorphins display reasonable affinities for kappa
3
binding sites, with K
i
values between 20 and 30 nM. Endomorphin 1 and Endomorphin 2 compete both μ
1
and μ
2
receptor sites quite potently. Endomorphins have little appreciable affinity for either
delta
or kappa
1
binding sites, with K
i
values greater than 500 nM.
Both Endomorphin 1 and Endomorphin 2 are potent analgesics with peak effects seen at 10 and 15 min, respectively. All subsequent studies are performed at peak effect. Both compounds are fully active supraspinally and spinally, with no indication of ceiling effects. Endomorphin 1 is significantly more potent spinally than supraspinally and, at the spinal level, it is significantly more potent than Endomorphin 2. The response of both agents are readily reversed by naloxone. β-FNA, a highly selective μ antagonist, effectively reverses the actions of both Endomorphins. Both Endomorphin 1 and Endomorphin 2 display a profile similar to morphine. Neither compound have analgesic activity in CXBK mice at a dose which produced over 70% analgesia in control CD-1 mice.
TYR-PRO-TRP-PHE-NH2
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-P0185 | TYR-PRO-TRP-PHE-NH2
Endomorphin 1 | 189388-22-5 | 5mg | 500元 |
| 2024/01/25 | HY-P0185 | TYR-PRO-TRP-PHE-NH2
Endomorphin 1 | 189388-22-5 | 10mM * 1mLin Water | 672元 |
189388-22-5, TYR-PRO-TRP-PHE-NH2 相关搜索:
- Opioid Peptides
- Neuropeptides
- Peptide
- Opioid receptor and opioid-like receptor
- Other Opioid PeptidesPeptides for Cell Biology
- Other Opioid Peptides
- SignalTransduction
- 人、小鼠或大鼠体内的内源性肽
- 目录肽
- 细胞信号和神经生物学
- 多肽
- 细胞生物学
- 生物活性小分子
- Other Opioid Peptides
- Opioid Peptides
- Peptides
- Amino Acids and Peptides
- BioChemical
- Biochemicals and Reagents
- C34H38N6O5
- 内吗啡肽 1、ENDOMORPHIN 1
- 内吗啡肽 1
- 内吗啡 1
- 189388-22-5
- (2S)-1-[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]-N-[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]pyrrolidine-2-carboxamide
- Endomorphin 1, Endomorphin 1
- (2S)-1-[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]-N-[(1S)-1-[[(1S)-1-carbamoyl-2-phenyl-ethyl]carbamoyl]-2-(1H-indol-3-yl)ethyl]pyrrolidine-2-carboxamide
- L-Phenylalaninamide,L-tyrosyl-L-prolyl-L-tryptophyl-
- YPWF-NH2
- TYR-PRO-TRP-PHE-NH2
- ENDOMORPHIN-1 (HUMAN, BOVINE)
- ENDOMORPHIN-1
- H-TYR-PRO-TRP-PHE-NH2
- L-Tyrosyl-L-prolyl-L-tryptophyl-L-phenylalaninamide