5-(N-乙基-N-异丙基)阿米洛利
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- CAS号:
- 1154-25-2
- 英文名:
- EIPA
- 英文别名:
- ethylisopropylamiloride;EIPA;MH 12-43;L 593754;Ethylisopropylamiloride (EIPA);5-(N-ETHYL-N-ISOPROPYL)AMILORIDE;AMILORIDE, 5-(N-ETHYL-N-ISOPROPYL)-;Amiloride,5-(N-Ethyl-N-isopropyl)-[5-(N-Ethyl-N-isopropyl)amiloride;3-AMino-N-(aMinoiMinoMethyl)-6-chloro-5-[ethyl(1-Methylethyl)aMino]-;3-amino-6-chloro-N-(diaminomethylene)-5-[ethyl(isopropyl)amino]pyrazinamide
- 中文名:
- 5-(N-乙基-N-异丙基)阿米洛利
- 中文别名:
- A盐酸盐;5-(N-乙基-N-异丙基)阿米洛利;TRPP3CHANNEL抑制剂(EIPA);5-(N-乙基-N-异丙基)阿米洛利(EIPA);3-氨基-N-氨基甲酰基-6-氯-5-(乙基(异丙基)氨基)吡嗪-2-甲酰胺
- CBNumber:
- CB1706411
- 分子式:
- C11H18ClN7O
- 分子量:
- 299.76
- MOL File:
- 1154-25-2.mol
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5-(N-乙基-N-异丙基)阿米洛利化学性质
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熔点:
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202-205 °C(lit.)
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密度:
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1.49±0.1 g/cm3(Predicted)
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储存条件:
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Keep in dark place,Sealed in dry,2-8°C
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溶解度:
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Acetonitrile (Slightly, Heated), DMSO (Slightly), Methanol (Slightly)
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酸度系数(pKa):
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8.67±0.46(Predicted)
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形态:
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Off-white to yellow solid.
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颜色:
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Pale Yellow to Green
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稳定性:
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Unstable in methanol
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CAS 数据库:
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1154-25-2
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5-(N-乙基-N-异丙基)阿米洛利性质、用途与生产工艺
EIPA (L593754) 是一种 TRPP3 channel 抑制剂，其 IC50 值为 10.5 μM。EIPA 还抑制 Na+/H+ 交换 (NHE) 和巨噬细胞。
IC50: 10.5 μM (TRPP3 channel)
NHE
Macropinocytosis
In the presence of 100 μM EIPA, 10 μM benzamil, and 10 μM phenamil,
45
Ca
2+
uptake decreases from 79±9 to 46±4 (58% remaining), 27±4 (34%), 29±5 (37%), and 38±4 (48%) pmol/oocyte/30 min (n=6, P=0.008), respectively. It is found that EIPA, benzamil, and phenamil rapidly and reversibly block Ca
2+
-activated TRPP3 channel activation at -50 mV, with IC
50
s of 143±8 (n=36), 10.5±2.2 (n=28), 1.1±0.3 (n=30), and 0.14±0.04 μM (n=25), respectively. The number of autophagic vacuoles increases dramatically in the HAE and HPE groups after EIPA treatment compare with the HAN and HPN groups. EIPA regulates the initiation and maturation of the autophagy associated with amino acids in IEC-18 cells. In addition, the uptake of cinnamoylphenazine (CA-PZ) and neutral red (NR) is inhibited by EIPA.
5-(N-乙基-N-异丙基)阿米洛利
上下游产品信息
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-101840 | 5-(N-乙基-N-异丙基)阿米洛利
EIPA | 1154-25-2 | 5mg | 500元 |
| 2024/01/25 | HY-101840 | 5-(N-乙基-N-异丙基)阿米洛利
EIPA | 1154-25-2 | 10mM * 1mLin DMSO | 550元 |
1154-25-2, 5-(N-乙基-N-异丙基)阿米洛利 相关搜索:
- Pharmaceuticals
- Nucleotides
- Intermediates & Fine Chemicals
- Inhibitors
- Bases & Related Reagents
- All Inhibitors
- 生化试剂
- 细胞生物学试剂
- 合成
- Voltage-gated Ion Channels
- Sodium Channel Modulators
- Ion Channels
- Monovalent Ion Channels
- BioChemical
- Amiloride and Derivatives
- Cell Biology
- Cell Signaling and Neuroscience
- C11H8ClN7O
- 5-(N-乙基-N-异丙基)阿米洛利(EIPA)
- A盐酸盐
- 3-氨基-N-氨基甲酰基-6-氯-5-(乙基(异丙基)氨基)吡嗪-2-甲酰胺
- TRPP3CHANNEL抑制剂(EIPA)
- 5-(N-乙基-N-异丙基)阿米洛利
- 1154-25-2
- ethylisopropylamiloride
- 2-Pyrazinecarboxamide, 3-amino-N-(aminoiminomethyl)-6-chloro-5-[ethyl(1-methylethyl)amino]-
- Ethylisopropylamiloride (EIPA)
- Amiloride,5-(N-Ethyl-N-isopropyl)-[5-(N-Ethyl-N-isopropyl)amiloride
- 3-AMino-N-(aMinoiMinoMethyl)-6-chloro-5-[ethyl(1-Methylethyl)aMino]-
- 3-aMino-N-carbaMiMidoyl-6-chloro-5-(ethyl(isopropyl)aMino)pyrazine-2-carboxaMide
- 3-azanyl-N-[bis(azanyl)methylidene]-6-chloro-5-[ethyl(propan-2-yl)amino]pyrazine-2-carboxamide
- 3-amino-6-chloro-N-(diaminomethylidene)-5-[ethyl(propan-2-yl)amino]pyrazine-2-carboxamide
- 3-amino-6-chloro-N-(diaminomethylene)-5-[ethyl(isopropyl)amino]pyrazinamide
- 6-Chloro-3-amino-5-[ethyl(isopropyl)amino]-N-(diaminomethylene)-2-pyrazinecarboxamide
- 3-Amino-5-[ethyl(isopropyl)amino]-6-chloro-N-(aminoiminomethyl)-2-pyrazinecarboxamide
- 3-Amino-5-(N-ethyl-N-isopropylamino)-6-chloro-N-(aminoiminomethyl)-2-pyrazinecarboxamide
- MH 12-43
- L 593754
- 3-Amino-N-(aminoiminomethyl)-6-chloro-5-[ethyl(1-methylethyl)amino]-2-pyrazinecarboxamide
- EIPA
- 3-AMINO-N-(AMINOIMINOMETHYL)-6-CHLORO-5-[ETHYL(2-PROPYL)AMINO]-PYRAZINE-2-CARBOXAMIDE
- 5-(N-ETHYL-N-ISOPROPYL)AMILORIDE
- AMILORIDE, 5-(N-ETHYL-N-ISOPROPYL)-