硫代秋水仙碱
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- CAS号:
- 2730-71-4
- 英文名:
- thiocolchicine
- 英文别名:
- NSC 186301;thiocolchicine;thiocholchicine;10-Thiocolchicine;Thiocolchicoside EP Impurity B;10-Demethoxy-10-methylthiocolchicine;(S)-7-Acetylamino-6,7-dihydro-10-methylthio-1,2,3-trimethoxybenzo[a]heptalen-9(5H)-one;(S)-7α-Acetylamino-6,7-dihydro-10-(methylthio)-1,2,3-trimethoxybenzo[a]heptalene-9(5H)-one;N-[(S)-5,6,7,9-Tetrahydro-1,2,3-trimethoxy-10-methylthio-9-oxobenzo[a]heptalen-7-yl]acetamide;(S)-N-(1,2,3-trimethoxy-10-(methylthio)-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide
- 中文名:
- 硫代秋水仙碱
- 中文别名:
- 硫秋水仙碱;硫代秋水仙碱;硫秋水仙苷杂质B;硫秋水仙素EP杂质B
- CBNumber:
- CB1926071
- 分子式:
- C22H25NO5S
- 分子量:
- 415.5
- MOL File:
- 2730-71-4.mol
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硫代秋水仙碱化学性质
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熔点:
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193℃
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比旋光度:
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D20 -221°
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沸点:
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729.1±60.0 °C(Predicted)
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密度:
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1.27±0.1 g/cm3(Predicted)
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储存条件:
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-20°C
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溶解度:
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DMSO: soluble10mg/mL, clear
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形态:
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powder
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酸度系数(pKa):
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14.75±0.40(Predicted)
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颜色:
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white to beige
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硫代秋水仙碱性质、用途与生产工艺
Thiocolchicine 是秋水仙碱 (HY-16569) 的衍生物，是一种有效的微管蛋白聚合 (tubulin polymerization) 抑制剂 (IC50=2.5 µM)，竞争性结合微管蛋白 (Ki=0.7 µM)。Thiocolchicine 可以作为 ADC 的毒素分子。
Thiocolchicine is against MCF-7, LoVo, LoVo/DX, A-549 and BALB/3T3 cells with IC
50
values of 0.01 μM, 0.021 μM, 0.398 μM, 0.011 μM and 0.114 μM, respectively.Thiocolchicine (1 nM-100 μM; 24-72 hours) shows a relationship between cell cycle blocking activity and growth inhibition in breast cancer cells. It inhibits cell proliferation of MDA-MB-231 and multidrug resistant (MDR) MCF-7 ADRr breast cancer cells with IC
50
s of 0.6 nM and 400 nM, respectively, as well as MDR CEM-VBL leukemia cells (IC
50
=50 nM).
硫代秋水仙碱
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/08/19 | HY-116852 | 硫代秋水仙碱
Thiocolchicine | 2730-71-4 | 5 mg | 500元 |
| 2024/08/19 | HY-116852 | 硫代秋水仙碱
Thiocolchicine | 2730-71-4 | 10 mg | 800元 |
2730-71-4, 硫代秋水仙碱 相关搜索:
- Pharmaceuticals
- Intermediates & Fine Chemicals
- 硫秋水仙苷杂质B
- 硫秋水仙素EP杂质B
- 硫秋水仙碱
- 硫代秋水仙碱
- 2730-71-4
- N-[(7S,12aRa)-1,2,3-trimethoxy-10-(methylsulfanyl)-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide (thiocolchicine)
- breast,LoVo/DX,MDR-positive,Microtubule/Tubulin,inhibit,MCF-7,leukemia,Colchicine,Apoptosis,BALB/3T3,cancer,A-549,LoVo,Thiocolchicine,Analogue,Inhibitor
- Acetamide, N-[(7S)-5,6,7,9-tetrahydro-1,2,3-trimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]-
- Thiocolchicoside EP Impurity B
- (S)-N-(1,2,3-trimethoxy-10-(methylthio)-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide
- NSC 186301
- N-[(7S)-5,6,7,9-Tetrahydro-1,2,3-triMethoxy-10-(Methylthio)-9-oxobenzo[a]heptalen-7-yl]acetaMide
- N-[(S)-5,6,7,9-Tetrahydro-1,2,3-trimethoxy-10-methylthio-9-oxobenzo[a]heptalen-7-yl]acetamide
- 10-Thiocolchicine
- 10-Demethoxy-10-methylthiocolchicine
- (S)-7α-Acetylamino-6,7-dihydro-10-(methylthio)-1,2,3-trimethoxybenzo[a]heptalene-9(5H)-one
- (S)-7-Acetylamino-6,7-dihydro-10-methylthio-1,2,3-trimethoxybenzo[a]heptalen-9(5H)-one
- thiocholchicine
- thiocolchicine