3,4-二羟基苯甲羟肟酸
|
|
- CAS号:
- 69839-83-4
- 英文名:
- dido
- 英文别名:
- dido;Didox;NSC-324360;Didox, NSC-324360;Didox Exclusive;4-Trihydroxybenzamide;N,3,4-trihydroxybenzamide;Benzamide, N,3,4-trihydroxy-;3,4-dihydroxybenzohydroxamic acid;N,3,4-Trihydroxybenzamide[N,3,4-Trihydroxybenzamide
- 中文名:
- 3,4-二羟基苯甲羟肟酸
- 中文别名:
- DIDOX游离态;4-二羟基苯甲羟肟酸;3,4-二羟基苯甲羟肟酸;N,3,4-三羟基苯甲酰胺
- CBNumber:
- CB21073551
- 分子式:
- C7H7NO4
- 分子量:
- 169.13
- MOL File:
- 69839-83-4.mol
|
|
|
3,4-二羟基苯甲羟肟酸化学性质
-
熔点:
-
207 °C
-
|
-
密度:
-
1.571±0.06 g/cm3(Predicted)
-
|
-
储存条件:
-
Inert atmosphere,Store in freezer, under -20°C
-
|
-
溶解度:
-
DMSO:60.0(Max Conc. mg/mL);354.76(Max Conc. mM)
DMF:20.0(Max Conc. mg/mL);118.25(Max Conc. mM) Ethanol:20.0(Max Conc. mg/mL);118.25(Max Conc. mM) PBS (pH 7.2):10.0(Max Conc. mg/mL);59.13(Max Conc. mM)-
|
-
形态:
-
A crystalline solid
-
|
-
酸度系数(pKa):
-
8.16±0.20(Predicted)
-
|
-
颜色:
-
Light yellow to khaki
-
|
3,4-二羟基苯甲羟肟酸性质、用途与生产工艺
Didox (NSC-324360) 是一种合成的核糖核苷酸还原酶 (ribonucleotide reductase, RR) 抑制剂。
Didox (NSC-324360) suppresses LPS-induced mRNA levels of iNOS, IL-6, IL-1, TNF-α, NF-κβ (p65), and p38-α, after 24 h of treatment. Treatment with Didox also suppresses the secretion of nitric oxide (NO), IL-6, and IL-10. Using mitochondrial dehydrogenase activity as a measure of cytotoxicity, the effects of Didox on cellular respiration in RAW264.7 are examined over a range of concentrations for 24 h. Cells exposures to 200 μM and below Didox, with and without LPS, do not exhibit significant cellular toxicity. Didox (NSC-324360) is active against all human and murine acute myeloid leukemia (AML) lines tested with IC
50
values in the low micromolar range (mean IC
50
37 µM [range 25.89-52.70 µM]).
Once engraftment is established by bioluminescent imaging, the animals receive daily administrations of Didox at 425 mg/kg via IP injection over 5 days. Didox (NSC-324360) treatment significantly reduces leukemic burden compared to vehicle treated controls (p=0.0026 and p=0.0342). More importantly, Didox (NSC-324360) provides a significant survival benefit (p<0.0001 and p=0.0094).
3,4-二羟基苯甲羟肟酸
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
---|
2024/08/19 | HY-19387 | 3,4-二羟基苯甲羟肟酸 Didox | 69839-83-4 | 5mg | 600元 |
2024/08/19 | HY-19387 | 3,4-二羟基苯甲羟肟酸 Didox | 69839-83-4 | 10mM * 1mLin DMSO | 660元 |
69839-83-4, 3,4-二羟基苯甲羟肟酸 相关搜索:
- 高端化学
- 标准品
- N,3,4-三羟基苯甲酰胺
- DIDOX游离态
- 4-二羟基苯甲羟肟酸
- 3,4-二羟基苯甲羟肟酸
- 69839-83-4
- N,3,4-Trihydroxybenzamide[N,3,4-Trihydroxybenzamide
- Benzamide, N,3,4-trihydroxy-
- NSC-324360
- 4-Trihydroxybenzamide
- Didox Exclusive
- Didox
- 3,4-dihydroxybenzohydroxamic acid
- dido
- Didox, NSC-324360
- N,3,4-trihydroxybenzamide