神经降压素
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- CAS号:
- 39379-15-2
- 英文名:
- NEUROTENSIN
- 英文别名:
- NEUROTENSIN;PYR-LYENKPRRPYIL;NEUROTENSIN (1-13);NEUROTENSIN, BOVINE;M.W. 1672.92 C78H121N21O20;NEUROTENSIN (HUMAN, BOVINE, CANINE);NEUROTENSIN (HUMAN, BOVINE, CANINE) 2ACOH 6H2O;Inhibitor,Neurotensin Receptor,Neurotensin,inhibit;PYR-LEU-TYR-GLU-ASN-LYS-PRO-ARG-ARG-PRO-TYR-ILE-LEU;GLP-LEU-TYR-GLU-ASN-LYS-PRO-ARG-ARG-PRO-TYR-ILE-LEU
- 中文名:
- 神经降压素
- 中文别名:
- 神经降压素?, >97%
- CBNumber:
- CB2118390
- 分子式:
- C78H121N21O20
- 分子量:
- 1672.92
- MOL File:
- 39379-15-2.mol
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神经降压素化学性质
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RTECS号:
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QQ4482000
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储存条件:
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Desiccate at -20°C
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溶解度:
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insoluble in EtOH; ≥15.33 mg/mL in DMSO; ≥22.55 mg/mL in H2O
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形态:
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Lyophilized powder.
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水溶解性:
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Soluble to 0.70 mg/ml in water
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序列:
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Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH
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神经降压素性质、用途与生产工艺
Neurotensin 是一种肠十三肽，作为有效的细胞有丝分裂原，作用于各种结肠直肠癌和胰腺癌，对神经降压素受体 (neurotensin receptor，NTR) 具有高亲和力。
Neurotensin receptors (NTR)
Neurotensin induces the expression of MIP-2, MCP-1, IL-1β and TNFα in murine microglial cells and stimulates IL-8 secretion in a non-transformed colon epithelial cell line stably transfected with the NTR. The high-affinity NTR, a member of the G-protein coupled receptor (GPCR) family, is present in a majority of human pancreatic and colorectal cancers, suggesting that Neurotensin (NT) may act in an endocrine fashion to affect tumor growth. Acting through the NTR1, Neurotensin is known to stimulate various signal transduction pathways, including intracellular calcium ([Ca
2+
]
i
), the mitogen-activated protein kinases (MAPKs), ERK and JNK, and various PKC isoforms. Treatment of HCT116 cells with Neurotensin (100 nM) significantly increases HCT116 cell migration (~3-fold) compared with vehicle treatment; pretreatment with Curcumin (10 μM) blocksthe stimulatory effect of NT on HCT116 cell migration. ctivation of MEK/ERK by NT and downstream induction of AP-1 transcription factors contributes to the proliferative effects of Neurotensin.
参考质量标准
外观:白色粉末
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%
神经降压素
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-P0234 | 神经降压素
Neurotensin | 39379-15-2 | 1mg | 500元 |
| 2024/01/25 | HY-P0234 | 神经降压素
Neurotensin | 39379-15-2 | 5mg | 1500元 |
39379-15-2, 神经降压素 相关搜索:
- peptide
- Neuromedins and related
- 抗体-一抗
- 目录肽
- 优势产品
- 目录多肽
- 多肽
- C78H121N21O20
- 神经降压素?, >97%
- 39379-15-2
- Inhibitor,Neurotensin Receptor,Neurotensin,inhibit
- Neurotensin，PYR-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu，Pyr-LYENKPRRPYIL
- Neurotensin,PYR-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu,Pyr-LYENKPRRPYIL?, >97%
- PGLU-LEU-TYR-GLU-ASN-LYS-PRO-ARG-ARG-PRO-TYR-ILE-LEU
- PYROGLU-LEU-TYR-GLU-ASN-LYS-PRO-ARG-ARG-PRO-TYR-ILE-LEU
- PYROGLU-LEU-TYR-GLU-ASN-LYS-PRO-ARG-ARG-PRO-TRP-ILE-LEU OH
- PYR-LEU-TYR-GLU-ASN-LYS-PRO-ARG-ARG-PRO-TYR-ILE-LEU-OH
- PYR-LEU-TYR-GLU-ASN-LYS-PRO-ARG-ARG-PRO-TYR-ILE-LEU 2ACOH 6H2O
- PYR-LEU-TYR-GLU-ASN-LYS-PRO-ARG-ARG-PRO-TYR-ILE-LEU
- PYR-LYENKPRRPYIL
- NEUROTENSIN
- NEUROTENSIN (1-13)
- NEUROTENSIN (HUMAN, BOVINE, CANINE) 2ACOH 6H2O
- NEUROTENSIN (HUMAN, BOVINE, CANINE)
- NEUROTENSIN, BOVINE
- GLP-LEU-TYR-GLU-ASN-LYS-PRO-ARG-ARG-PRO-TYR-ILE-LEU
- M.W. 1672.92 C78H121N21O20