TAS 103
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- CAS号:
- 174634-08-3
- 英文名:
- TAS 103
- 英文别名:
- TAS 103;CS-1287;BMS-247615;TAS-103 HC1;TAS-103 base;TAS-103(salt);TA103(bms-247615);6-[[2-(Dimethylamino)ethyl]amino]-3-hydroxy-7H-indeno[2,1-c]quinolin-7-one;7H-Indeno[2,1-c]quinolin-7-one, 6-[[2-(dimethylamino)ethyl]amino]-3-hydroxy-
- 中文名:
- TAS 103
- 中文别名:
- 6-[[2-(二甲基氨基)乙基]氨基]-3-羟基-7H-茚并[2,1-C]喹啉-7-酮
- CBNumber:
- CB21321579
- 分子式:
- C20H19N3O2
- 分子量:
- 333.38
- MOL File:
- 174634-08-3.mol
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TAS 103化学性质
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熔点:
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216-217 °C(Solv: ethanol (64-17-5))
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沸点:
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589.5±50.0 °C(Predicted)
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密度:
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1.350±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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7.88±0.20(Predicted)
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TAS 103性质、用途与生产工艺
TAS-103 是一种 DNA 拓扑异构酶 I/II (topoisomerase I/II) 双重抑制剂，可用于癌症研究。
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Topoisomerase I
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Topoisomerase II
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TAS-103 is a dual inhibitor of DNA topoisomerase I/II. TAS-103 (0.1-10 μM) is active on CCRF-CEM cells, with an IC
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value of 5 nM. TAS-103 (0.1 μM) significantly increases levels of topo IIα FITC immunofluorescence in individual CCRF-CEM cells. TAS-103 (0.01-1 μM) is highly cytotoxic to Lewis lung carcinoma (LLC) cells, and Liposomal TAS-103 is almost as active as free TAS-103. TAS-103 inhibits the viability of HeLa cells, with an IC
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of 40 nM. TAS-103 (10 μM) disrupts signal recognition particle (SRP) complex formation, and induces destabilization of SRP14 and SRP19 and its eventual degradation.
TAS-103 (30 mg/kg, i.v.) causes significant tumor growth suppression in mice bearing Lewis lung carcinoma (LLC) cells, without obvious body weight loss, and the liposomal TAS-103 is more active than free TAS-103.
TAS 103
上下游产品信息
上游原料
下游产品
174634-08-3, TAS 103 相关搜索:
- 6-[[2-(二甲基氨基)乙基]氨基]-3-羟基-7H-茚并[2,1-C]喹啉-7-酮
- 174634-08-3
- 7H-Indeno[2,1-c]quinolin-7-one, 6-[[2-(dimethylamino)ethyl]amino]-3-hydroxy-
- CS-1287
- TAS-103 base
- TAS-103(salt)
- BMS-247615
- TA103(bms-247615)
- TAS-103 HC1
- 6-[[2-(Dimethylamino)ethyl]amino]-3-hydroxy-7H-indeno[2,1-c]quinolin-7-one
- TAS 103