地拉卓二盐酸盐
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- CAS号:
- 20153-98-4
- 英文名:
- DILAZEP DIHYDROCHLORIDE
- 英文别名:
- cormelian;astac;k-285;C12954;C-4898;labitan;comelian;astac4898;DILAZEP DIHYDROCHLORIDE;h)dipropanol,dihydrochloride
- 中文名:
- 地拉卓二盐酸盐
- 中文别名:
- 地拉卓二盐酸盐;1,4-双[3-(3,4,5-三甲氧基苯甲酰氧基)丙基]高哌嗪二盐酸盐;(1,4-二氮杂环庚烷-1,4-二基)双(丙烷-3,1-二基) 双(3,4,5-三甲氧基苯甲酸酯) 二盐酸盐
- CBNumber:
- CB2143031
- 分子式:
- C31H46Cl2N2O10
- 分子量:
- 677.61
- MOL File:
- 20153-98-4.mol
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地拉卓二盐酸盐化学性质
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熔点:
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194-198° (monohydrate)
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储存条件:
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2-8°C
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溶解度:
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H2O: 10 mg/mL
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形态:
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powder
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颜色:
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white
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水溶解性:
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Soluble to 100 mM in water
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地拉卓二盐酸盐性质、用途与生产工艺
Dilazep dihydrochloride 是腺苷摄取的抑制剂。Dilazep dihydrochloride 通过增强腺苷的作用而具有脑和冠状血管舒张作用。Dilazep dihydrochloride 还可抑制缺血性损伤，血小板聚集和核苷的膜转运。
The uptake mechanism has been studied extensively in vitro and Dilazep, NBI and Dipyridamole have been reported to inhibit the uptake of adenosine into different cells. Of these compounds, Dilazep and NBI are almost 10 times more potent than Dipyridamole. In addition, only Dilazep is water soluble and no solubility aiding organic solvent is needed for preparing an aqueous solution.
After administration of Dilazep, even low doses (0.04-0.1 mg/kg/min) of exogenous adenosine significantly increases superior mesenteric arterial conductance (SMAC) and elevates arterial plasma adenosine concentration. The increased adenosine levels were highly correlated with the increased percentage of change of SMAC and values for R
max
and EC
50
were 193.4% change of SMAC and 2.8 μM, respectively. Administration of bolus doses of 8-phenyltheophylline abolishes the ability of Dilazep to potentiate vasodilation, but did not affect isoproterenol-induced relaxation.
Dilazep inhibits the phospholipase activation in reperfused heart mitochondria and also inhibits the lipid peroxidation caused by cerebral ischemia and reperfusion. Dilazep may prevent ischemic cerebral injury due to an increase in cerebral blood flow and/or its protective effects on vascular endothelial cell membrane.
地拉卓二盐酸盐
上下游产品信息
上游原料
下游产品
20153-98-4, 地拉卓二盐酸盐 相关搜索:
3,4-二甲氧基-5-羟基苯甲酸 3,4-二羟基-5-甲氧基苯甲酸甲酯 3,4,5-三甲氧基苯甲酸乙酯 丁香酸 3,4-二羟基苯甲酸乙酯 海索苯定 1-乙基高哌嗪 丁香酸甲酯 3,5-二甲氧基苯甲酸 双酯嗪 3,5-二羟基苯甲酸甲酯 甲基-Β-D-吡喃半乳糖苷 3,4,5-三甲氧基苯甲酸 没食子酸丙酯 3,4,5-三甲氧基苯甲酸甲酯 3,5-二乙氧基基苯甲酸甲酯 3,4-二甲氧基-5-羟基苯甲酸甲酯 高哌嗪
- 药靶配体
- C31H44N2O102HCl
- C31H46N2O102Cl
- (1,4-二氮杂环庚烷-1,4-二基)双(丙烷-3,1-二基) 双(3,4,5-三甲氧基苯甲酸酯) 二盐酸盐
- 1,4-双[3-(3,4,5-三甲氧基苯甲酰氧基)丙基]高哌嗪二盐酸盐
- 地拉卓二盐酸盐
- 20153-98-4
- ischemic,Adenosine,Dilazep dihydrochloride,uptake,vasodilation,potentiate,Inhibitor,cerebral,damage,inhibit,Dilazep
- cormelian
- (1,4-diazepane-1,4-diyl)bis(propane-3,1-diyl) bis(3,4,5-trimethoxybenzoate) dihydrochloride
- labitan
- ASTA C 4898, Cormelian, N,Nμ-bis(3-[3,4,5-Trimethoxybenzoyloxy]propyl)homopiperazine dihydrochloride
- DILAZEP DIHYDROCHLORIDE (COMELIAN, CORME LIAN, ASTA C) \ ADENOSINE UPTAKE INHIB
- (tetrahydro-1H-1,4-diazepine-1,4(5H)-diyl)di(propane-1,3-diyl) bis(3,4,5-trimethoxybenzoate) dihydrochloride
- n,n’-(bis-omega-hydroxypropyl)homopiperazine3,4,5-trimethoxybenzoatedihydro
- k-285
- h)dipropanol,dihydrochloride
- C12954
- C-4898
- comelian
- benzoicacid,3,4,5-trimethoxy-,diesterwithtetrahydro-1h-1,4-diazepine-1,4(5
- astac4898
- astac
- 1,4-bis(3-(3,4,5-trimethoxybenzoyloxy)-propyl)perhydro-1,4-diazepinedihydroc
- N,N'-BIS[3-(3,4,5-TRIMETHOXY-BENZOYLOXY)PROPYL]HOMOPIPER-AZINE DIHYDROCHLORIDE
- 1,4-BIS[3-(3,4,5-TRIMETHOXYBENZOYLOXY)PROPYL]HOMOPIPERAZINE DIHYDROCHLORIDE
- DILAZEP DIHYDROCHLORIDE