格隆溴铵中间体
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- CAS号:
- 13118-10-0
- 英文名:
- 1-Methyl-3-(a-cyclopentylmandeloyloxy)pyrrolidinehydrochloride
- 英文别名:
- 1-Methylpyrrolidin-3-yl 2-cyclopentyl-2-hydroxy-2-phenylacetate hydrochloride;Ahr-376;Ahr 376;AHR 376 (hydrochloride);Glycopyrrolate Intermediate;Glycopyrrolate Impurity 30 HCl;Glycopyrrolate Bromide iMpurit G;Glycopyrrolate Related Compound B HCl;Glycopyrronium Bromide EP Impurity G HCl;Glycopyrrolate USP Related Compound B HCl
- 中文名:
- 格隆溴铵中间体
- 中文别名:
- 化合物 T29746;格隆溴铵杂质B盐酸盐;格隆溴铵杂质30 盐酸盐;格隆溴铵EP杂质G盐酸盐;格隆溴铵相关化合物B盐酸盐;格隆溴铵USP相关杂质B HCL;格隆溴铵杂质IV(USP 杂质B);1-甲基-3-(A-环戊基扁桃酰氧基)吡咯烷盐酸盐;1-甲基-3-(Α-环戊基扁桃酰氧基)吡咯烷盐酸盐;1-甲基吡咯烷-3-基 2-环戊基-2-羟基-2-苯乙酸酯盐酸盐
- CBNumber:
- CB21450767
- 分子式:
- 分子量:
- 0
- MOL File:
- 13118-10-0.mol
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格隆溴铵中间体化学性质
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熔点:
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164-166 °C(Solv: acetonitrile (75-05-8))
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储存条件:
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Inert atmosphere,Room Temperature
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格隆溴铵中间体性质、用途与生产工艺
用途
胃长宁的中间体。
生产方法
用苯乙烯以高锰酸钾氧化，生成苯乙酮酸，然后与甲醇在硫酸参与下酯化得苯乙酮酸甲酯，将后者与环戊二烯加成（格氏反应，先以金属镁、无水乙醚、溴乙烷制成格氏试剂），得α-环戊二烯基扁桃酸甲酯，进而在活性镍作用下加压催化氢化，最后与N-甲基吡咯烷-3-醇酯交换制得该品。
类别
有毒物品
毒性分级
高毒
急性毒性
口服-小鼠 LD50：500 毫克/公斤; 腹腔-小鼠LD50: 250 毫克/公斤
可燃性危险特性
可燃; 燃烧释放有毒氮氧化物和氯化氢烟雾
储运特性
库房通风低温干燥; 与食品原料分开存放
灭火剂
干粉、泡沫、砂土、二氧化碳, 雾状水
格隆溴铵中间体
上下游产品信息
上游原料
下游产品
13118-10-0, 格隆溴铵中间体 相关搜索:
- 格隆溴铵杂质B盐酸盐
- 格隆溴铵EP杂质G盐酸盐
- 格隆溴铵USP相关杂质B HCL
- 格隆溴铵杂质30 盐酸盐
- 化合物 T29746
- 1-甲基吡咯烷-3-基 2-环戊基-2-羟基-2-苯基乙酸酯盐酸盐
- 格隆溴铵杂质IV(USP 杂质B)
- 1-甲基吡咯烷-3-基 2-环戊基-2-羟基-2-苯乙酸酯盐酸盐
- 格隆溴铵相关化合物B盐酸盐
- 1-甲基-3-(A-环戊基扁桃酰氧基)吡咯烷盐酸盐
- 1-甲基-3-(Α-环戊基扁桃酰氧基)吡咯烷盐酸盐
- 13118-10-0
- Glycopyrronium Bromide EP Impurity G HCl
- Glycopyrronium Bromide EP Impurity G as Hydrochloride
- Glycopyrrolate USP Related Compound B as Hydrochloride
- 1-Methylpyrrolidin-3-yl 2-cyclopentyl-2-hydroxy-2-phenylacetate hydrochloride
- Glycopyrrolate USP Related Compound B HCl
- Glycopyrrolate Impurity 30 HCl
- Glycopyrrolate Intermediate
- 2-cyclopentyl-2-hydroxy-2-phenylacetic acid (1-methyl-3-pyrrolidinyl) ester hydrochloride
- Glycopyrrolate Related Compound B HCl
- AHR 376 (hydrochloride)
- Glycopyrrolate Bromide iMpurit G
- N-Methyl-3-pyrrolidinyl Cyclopentylmandelate Hydrochloride
- Mandelic acid, .alpha.-cyclopentyl-, 1-methyl-3-pyrrolidinyl, hydrochloride
- Mandelic acid, .alpha.-cyclopentyl-, 1-methyl-3-pyrrolidinyl ester, hydrochloride
- Benzeneacetic acid, .alpha.-cyclopentyl-.alpha.-hydroxy-, 1-methyl-3-pyrrolidinyl ester, hydrochloride
- Ahr-376
- Ahr 376
- 3-Pyrrolidinol, 1-methyl-, .alpha.-cyclopentylmandelate, hydrochloride
- 1-Methyl-3-pyrrolidyl .alpha.-phenylcyclopentylmandelate hydrochloride
- 1-Methyl-3-pyrrolidyl .alpha.-phenylcyclopentylglycolate hydrochloride
- 1-Methyl-3-pyrrolidinyl .alpha.-cyclopentylmandelic acid hydrochloride
- mandelic acid, alpha-cyclopentyl-, 1-methyl-3-pyrrolidinyl ester, hydrochloride 1-methyl-3-pyrrolidyl alpha-phenylcyclopentaneglycolate hydrochloride
- ahr 376 alpha-cyclopentylmandelic acid 1-methyl-3-pyrrolidinyl ester hydrochloride mandelic acid, alpha-cyclopentyl-,1-methyl-3-pyrrolidinyl ester, hydrochloride 1-Methyl-3-(-cyclopentylmandeloyloxy)pyrrolidine hydrochloride 1-Methyl-3-pyrrolidinyl -cyclopentylmandelate hydrochloride
- 1-Methyl-3-(a-cyclopentylmandeloyloxy)pyrrolidinehydrochloride