N,N'-八亚甲基双二氯乙酰胺
|
|
- CAS号:
- 1477-57-2
- 英文名:
- N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE)
- 英文别名:
- SKL878;r-010-tk;win18441;win18446;win18,446;NSC 59354;bisdiamine;FERTILYSIN;bis-diamine;Fertilysine
- 中文名:
- N,N'-八亚甲基双二氯乙酰胺
- 中文别名:
- 佛替来辛;N,N'-八亚甲基双二氯乙酰胺;N,N'-八亚甲基双二氯乙酰胺;N,N′-八亚甲基双(2,2-二氯乙酰胺);N,N′-双(二氯乙酰基)-1,8-八亚甲基二胺;N,N'-1,8-辛二基双[2,2-二氯]乙酰胺;N,N'-(辛烷-1,8-二基)双(2,2-二氯乙酰胺);N,N'-(辛烷-1,8-二基)双(2,2-二氯乙酰胺)
- CBNumber:
- CB2146249
- 分子式:
- C12H20Cl4N2O2
- 分子量:
- 366.11
- MOL File:
- 1477-57-2.mol
|
|
|
N,N'-八亚甲基双二氯乙酰胺化学性质
-
熔点:
-
118-120 °C
-
|
-
沸点:
-
530℃
-
|
-
密度:
-
0.726
-
|
-
折射率:
-
1.6200 (estimate)
-
|
-
闪点:
-
275℃
-
|
-
储存条件:
-
Inert atmosphere,2-8°C
-
|
-
溶解度:
-
Acetone (Very Slightly), DMSO (Slightly), Methanol (Sparingly, Heated, Sonicated
-
|
-
酸度系数(pKa):
-
12.28±0.46(Predicted)
-
|
-
形态:
-
Solid
-
|
-
颜色:
-
White to Off-White
-
|
-
CAS 数据库:
-
1477-57-2
-
|
N,N'-八亚甲基双二氯乙酰胺性质、用途与生产工艺
Win 18446 是具有口服活性的睾丸特异性的酶 ALDH1a2 的抑制剂,其 IC50 值为 0.3 μM。Win 18446 可逆的抑制多个物种的精子形成,抑制睾丸内视黄醇 (HY-B1342) 合成视黄酸 (HY-14649)。
WIN 18446 (1 μM, 24 h) is able to suppress Stra8 expression in whole-testes cultures that contained both germ and somatic cells.
RT-PCR
Cell Line:
|
Testes were collected from 2-dpp mice.
|
Concentration:
|
1 μM.
|
Incubation Time:
|
24 h.
|
Result:
|
Results in a VAD-like phenotype in the testis.
Alone or in combination with ROL significantly reduced
Stra8
expression.
|
Win 18446 (200 mg/kg, Orally for 4, 8, and 16 weeks) significantly reduces intratesticular concentrations of retinoic acid, severely impaired spermatogenesis, and caused infertility.
Animal Model:
|
Six-month-old male New Zealand white rabbits.
|
Dosage:
|
200 mg/kg.
|
Administration:
|
Orally for 4, 8, and 16 weeks.
|
Result:
|
Resulted in marked suppression of testicular weight over time.
Dramatically suppressed spermatogenesis.
Significantly reduces intratesticular concentrations of retinoic acid and Stra8 expression and very severely suppresses spermatogenesis and fertility.
|
类别
有毒物品
毒性分级
高毒
急性毒性
腹腔-小鼠 LDL0: 150 毫克/公斤
可燃性危险特性
可燃; 受热产生有毒氮氧化物,氯化物烟雾; 药物副作用:恶心,呕吐,精子形成改变
储运特性
库房通风低温干燥; 与食品原料分开存放
灭火剂
干粉,泡沫,沙土,二氧化碳, 雾状水
N,N'-八亚甲基双二氯乙酰胺
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
---|
2024/08/19 | HY-W011094 | N,N'-八亚甲基双二氯乙酰胺 Win 18446 | 1477-57-2 | 50mg | 973元 |
2024/08/19 | HY-W011094 | N,N'-八亚甲基双二氯乙酰胺 Win 18446 | 1477-57-2 | 10mM * 1mLin DMSO | 1100元 |
1477-57-2, N,N'-八亚甲基双二氯乙酰胺 相关搜索:
- 有机中间体
- 其它
- C12H20Cl4N2O2
- N,N'-八亚甲基双二氯乙酰胺
- N,N'-(辛烷-1,8-二基)双(2,2-二氯乙酰胺)
- N,N'-(辛烷-1,8-二基)双(2,2-二氯乙酰胺)
- N,N'-八亚甲基双二氯乙酰胺
- 佛替来辛
- N,N′-双(二氯乙酰基)-1,8-八亚甲基二胺
- N,N′-八亚甲基双(2,2-二氯乙酰胺)
- N,N'-1,8-辛二基双[2,2-二氯]乙酰胺
- 1477-57-2
- ACETAMIDE,N,N'-1,8-OCTANEDIYLBIS[2,2-DICHLORO-
- N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE)
- N,N'-(Octane-1,8-diyl)bis(2,2-dichloroacetamide)
- 2,2-dichloro-N-[8-[(2,2-dichloroacetyl)amino]octyl]acetamide
- WIN 18446,Stra8,testis,spermatogenesis,inhibit,Win18446,Aldehyde Dehydrogenase (ALDH),Testes,Win-18446,Inhibitor
- SKL878
- Fertilysine
- AcetaMide,N,N'-1,8-octanediylbis[2,2-dichloro-
- N,N'-(Octane-1,8-diyl)bis(2,2-dichloroacetaMide)
- N,N'-Octamethylenebis(dichloroacetamide),97%
- N,N'-(1,8-Octanediyl)bis(2,2-dichloroacetamide)
- N,N''-OCTMETHYLENEBIS (DICHLOROACETAMIDE)
- NSC 59354
- win18446
- win18441
- win18,446
- r-010-tk
- n,n-bis(dichloroacetyl)-1,8-octanediamine
- n,n’-octamethylenebis(2,2-dichloroactamide)
- n,n’-octamethylenebis(2,2-dichloro-acetamid
- n,n’-bis(dichloroacetyl)-1,8-octanediamine
- n,n’-bis(dichloroacetyl)-1,8-diaminooctane
- n,n’,1,8-octanediylbis(2,2-dichloro-acetamid
- bis-diamine
- bisdiamine
- N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE)
- N,N'-OCTA-METHYLENE-BIS[2,2-DICHLOROACETAMIDE]
- N,N'-BIS(DICHLOROACETYL)-1,8-OCTAMETHYLENEDIAMINE
- FERTILYSIN