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盐酸阿柔比星

盐酸阿柔比星, 75443-99-1, 结构式
盐酸阿柔比星
CAS号:
75443-99-1
英文名:
ACLARUBICIN HYDROCHLORIDE
英文别名:
aclacinon;Aclarubicin HCl;Aclarubicin hydrochlride;ACLARUBICIN HYDROCHLORIDE;aclacinomycinahydrochloride;ACLARUBICIN HYDROCHLORIDE USP/EP/BP;Aclarubicin hydrochloride (Aclacinomycin A);syl)oxy)-2,5,7-trihydroxy-,methylester,hydrochloride,(1r-(1-alpha,2-beta,4;n-2-yl)-alpha-l-lyxo-hexopyranosyl)-3-(dimethylamino)-alpha-l-lyxo-hexopyrano;1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R-trans)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-alpha-l-lyxo-hexopyranosyl]-3-(dimethylamino)-alpha-l-lyxo
中文名:
盐酸阿柔比星
中文别名:
盐酸阿柔比星;阿柔比星盐酸盐;阿克拉霉素盐酸盐
CBNumber:
CB2189954
分子式:
C42H54ClNO15
分子量:
848.33
MOL File:
75443-99-1.mol

盐酸阿柔比星化学性质

熔点:
151-153℃
沸点:
898℃
闪点:
>110°(230°F)
储存条件:
2-8°C
溶解度:
Soluble in DMSO or DMF at 25mg/ml
安全信息
危险品标志: T
危险类别码: 23/24/25
安全说明: 36/37/39-45
危险品运输编号: 3249
RTECS号: QI9283500
危险等级: 6.1(a)
包装类别: II

盐酸阿柔比星 化学药品说明书


注射用盐酸阿柔比星

盐酸阿柔比星性质、用途与生产工艺

生物活性

Aclacinomycin A hydrochloride (Aclarubicin hydrochloride) 是一种荧光分子,是第一个发现对 20S 蛋白酶体 (20S proteasome) 的 CTRL (糜凝乳蛋白酶样) 活性具有离散特异性的非肽性抑制剂。同时也是 拓扑异构酶 I 和 II (topoisomerase I and II) 的双抑制剂。是一种有效蒽环类化疗试剂用于血癌和实体肿瘤的相关研究。

靶点

20S proteasome.
Topoisomerase I and II.

体外研究

Aclacinomycin A could efficiently enter living cells and emit fluorescence in situ . Aclacinomycin A (10 μM for 15 min) is sufficient for clear detection of fluorescence in most of the cultured cells. Aclacinomycin A treatment (10 μM Acla for 15 min) results in approximately 20% dead (or nearly dead) cells.
Aclacinomycin A (Aclarubicin) effectively induces incorporation of exon 7 into SMN2 transcripts from the endogenous gene in type I SMA fibroblasts as well as into transcripts from a SMN2 minigene in the motor neuron cell line NSC34 .

体内研究

Aclacinomycin A is very well absorbed in mice, rats, and dogs after its oral administration. The oral LD 50 (76.5 mg/kg) is about twice the iv LD 50 (35.6 mg/kg) in mice [4 .
Aclacinomycin A (0.75-6 mg/kg, ip daily) dose-dependently exhibits tumor growth in mice-based Leukemia P-388 model [4 .

Animal Model: DBA/2, CDF 1 (BALB/c×DBA/2) mice with Leukemia P-388 [4 .
Dosage: 0.75 mg/kg, 1.5 mg/kg, 3 mg/kg, 6 mg/kg.
Administration: Intraperitoneal administration daily for 10 days starting 3 hr after transplantation.
Result: Inhibited tumor growth.

盐酸阿柔比星 上下游产品信息

上游原料

下游产品

盐酸阿柔比星 试剂级价格

更新日期产品编号产品名称CAS编号包装价格
2023/01/06HY-N2306A盐酸阿柔比星
Aclacinomycin A hydrochloride
75443-99-15mg2800元
2023/01/06HY-N2306A盐酸阿柔比星
Aclacinomycin A hydrochloride
75443-99-110 mM * 1 mLin DMSO4479元

盐酸阿柔比星 生产厂家

全球有 40家供应商   盐酸阿柔比星国内生产厂家
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上海复和化学科技有限公司 0086-21-67651709 cfx759@hotmail.com 中国 410 57
上海瀚香生物科技有限公司 17754423994 17754423994 2853530910@QQ.com 中国 8018 62
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Dideu Industries Group Limited +86-29-89586680 +86-15129568250 1026@dideu.com 中国 29831 58
AFINE CHEMICALS LIMITED 0571-85134551 info@afinechem.com 中国 15377 58
BOC Sciences info@bocsci.com 美国 0 65
BOC Sciences +1-631-485-4226 inquiry@bocsci.com 美国 19553 58
陕西缔都医药化工有限公司 +86-29-87569266 15319487004 1015@dideu.com 中国 2263 58
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InvivoChem中国 13549236410 sales@invivochem.cn 中国 6712 58
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Shanghai Acmec Biochemical Technology Co., Ltd. +undefined18621343501 product@acmec-e.com 中国 33349 58
 

75443-99-1, 盐酸阿柔比星 相关搜索:

  • API
  • C42H53NO15HCl
  • C42H54ClNO15
  • 阿克拉霉素盐酸盐
  • 阿柔比星盐酸盐
  • 盐酸阿柔比星
  • 75443-99-1
  • methyl(1R,2R,4S)-4-[(2R,4S,5S,6S)-4-(dimethylamino)-5-[(2S,4S,5S,6S)-4-hydroxy-6-methyl-5-[(2R,6S)-6-methyl-5-oxooxan-2-yl]oxyoxan-2-yl]oxy-6-methyloxan-2-yl]oxy-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-3,4-dihydro-1H-tetracene-1-carboxylate,hydrochloride
  • ACLARUBICIN HYDROCHLORIDE USP/EP/BP
  • Aclarubicin hydrochloride (Aclacinomycin A)
  • Aclarubicin HCl
  • Aclarubicin hydrochlride
  • 1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R-trans)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-α-L-lyxo-hexopyranosyl]-3-(dimethylamino)-α-L-lyxo-hexopyranosyl]oxy]-, methyl ester, hydrochloride, [1R-(1α,2β,4β)]-
  • 1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R,6S)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-α-L-lyxo-hexopyranosyl]-3-(dimethylamino)-α-L-lyxo-hexopyranosyl]oxy]-, meth
  • ACLARUBICIN HYDROCHLORIDE
  • 1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R-trans)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-alpha-l-lyxo-hexopyranosyl]-3-(dimethylamino)-alpha-l-lyxo
  • syl)oxy)-2,5,7-trihydroxy-,methylester,hydrochloride,(1r-(1-alpha,2-beta,4
  • n-2-yl)-alpha-l-lyxo-hexopyranosyl)-3-(dimethylamino)-alpha-l-lyxo-hexopyrano
  • aclacinon
  • aclacinomycinahydrochloride
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