ACOLBIFENE
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- CAS号:
- 151533-34-5
- 英文名:
- ACOLBIFENE
- 英文别名:
- ACOLBIFENE;(Rac)-EM-652;rac-Acolbifene;2H-1-Benzopyran-7-ol, 3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidinyl)ethoxy]phenyl]-;2-[4-[2-(1-piperidino)ethoxy]phenyl]-3-(4-hydroxyphenyl)-4-Methyl-7-hydroxy-2H-1-benzopyran
- 中文名:
- ACOLBIFENE
- 中文别名:
- 化合物 T12654
- CBNumber:
- CB22451259
- 分子式:
- C29H31NO4
- 分子量:
- 457.56
- MOL File:
- 151533-34-5.mol
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ACOLBIFENE化学性质
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沸点:
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651.5±55.0 °C(Predicted)
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密度:
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1.217±0.06 g/cm3(Predicted)
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溶解度:
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DMSO: 100 mg/mL (218.55 mM)
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酸度系数(pKa):
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9.70±0.40(Predicted)
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ACOLBIFENE性质、用途与生产工艺
(Rac)-Acolbifene (EM-343; (Rac)-EM-652) 是 EM652 (estrogen receptor 拮抗剂) 的外消旋形式,具有抗雌激素和雌激素活性。 (Rac)-Acolbifene (EM-343; (Rac)-EM-652) 含哌啶环,具有良好的药理作用,RBA=380。
(Rac)-Acolbifene (EM-343; (Rac)-EM-652) shows a inhibitory effect in T-47D cells with an IC
50
value of 0.110 nM.
Cell Viability Assay
Cell Line:
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T-47D cells
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Concentration:
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0.110 nM
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Incubation Time:
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72 hours
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Result:
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Inhibited T-47D cells growth.
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(Rac)-Acolbifene (orally adminstration; 7.5 nM, 75 nM; 9 days; once daily) shows a good pharmacological profile in ovariectomized mice, shows 63% and 84% antiuterotrophic inhibitions at the 7.5 and 75 nM doses, respectively (PK study, ovariectomized mice).
ACOLBIFENE
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上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-16023A | Acolbifene | | 1 mg | 761元 |
2024/04/30 | HY-16023B | ACOLBIFENE (Rac)-Acolbifene | 151533-34-5 | 5mg | 1500元 |
151533-34-5, ACOLBIFENE 相关搜索:
- 化合物 T12654
- 151533-34-5
- 2H-1-Benzopyran-7-ol, 3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidinyl)ethoxy]phenyl]-
- (Rac)-EM-652
- ACOLBIFENE
- rac-Acolbifene
- 2-[4-[2-(1-piperidino)ethoxy]phenyl]-3-(4-hydroxyphenyl)-4-Methyl-7-hydroxy-2H-1-benzopyran