化合物GR 125743
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- CAS号:
- 148547-33-5
- 英文名:
- GR 125743
- 英文别名:
- GR 125743;Benzamide, N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]-3-methyl-4-(4-pyridinyl)-;h5-HT1B,cognitive disorder,h5-HT1D,cardiovascular,GR-125743,GR125743,inhibit,Parkinson's disease,5-HT Receptor,GR 125743,5-hydroxytryptamine Receptor,receptor,Inhibitor,Serotonin Receptor
- 中文名:
- 化合物GR 125743
- 中文别名:
- 化合物GR 125743
- CBNumber:
- CB22487573
- 分子式:
- C25H28N4O2
- 分子量:
- 416.52
- MOL File:
- 148547-33-5.mol
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化合物GR 125743化学性质
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储存条件:
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4°C, protect from light
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溶解度:
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DMSO: 100 mg/mL (240.08 mM)
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化合物GR 125743性质、用途与生产工艺
GR 125743 是一种选择性的 5-HT1B/1D 受体拮抗剂，与野生型的人 h5-HT1B 和 5-HT1D 结合的 pKi 分别为 8.85 和 8.31。GR 125743 可用于帕金森病和心血管疾病的研究。
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human 5-HT
1B
Receptor
8.85 (pKi)
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human 5-HT
1D
Receptor
8.31 (pKi)
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GR 125743 has a
K
d
of 0.61 nM for h5-HT
1B
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GR 125743 (0.3 mg/kg; i.p.) produces significant decreases in extracellular 5-HT in the frontal cortex of the conscious guinea pig.
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Animal Model:
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Male Dunkin Hartley guinea-pigs (350–450 g)
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Dosage:
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0.3 mg/kg
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Administration:
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Intraperitoneal injection
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Result:
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Produced significant transient increases in extracellular 5-HT.
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化合物GR 125743
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-121392 | GR 125743 | | 1 mg | 380元 |
| 2024/01/25 | HY-121392 | 化合物GR 125743
GR 125743 | 148547-33-5 | 5mg | 1000元 |
148547-33-5, 化合物GR 125743 相关搜索:
- Serotonin
- 化合物GR 125743
- 148547-33-5
- h5-HT1B,cognitive disorder,h5-HT1D,cardiovascular,GR-125743,GR125743,inhibit,Parkinson's disease,5-HT Receptor,GR 125743,5-hydroxytryptamine Receptor,receptor,Inhibitor,Serotonin Receptor
- Benzamide, N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]-3-methyl-4-(4-pyridinyl)-
- GR 125743