米托蒽醌甲磺酸盐
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- CAS号:
- 845959-50-4
- 英文名:
- Mitoquinone mesylate
- 英文别名:
- MitoQ;MitoQ mesylate;MitoQ10 mesylate;Mitoquinol Mesylate;Mitoquinone mesylate;Mitoquinone mesylate (MitoQ);Mitoquinone (MitoQ10) mesylate;Mitoquinone mesylate, ethanol solution;Mitoquinone mesylate (Mitoquinone methanesulfonate;10-(4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)decyl-triphenylphosphanium,methanesulfonate
- 中文名:
- 米托蒽醌甲磺酸盐
- 中文别名:
- 米托醌甲磺酸盐;米托蒽醌甲磺酸盐;甲磺酸米托醌(米托Q10)
- CBNumber:
- CB22505185
- 分子式:
- C38H47O7PS
- 分子量:
- 678.814341
- MOL File:
- 845959-50-4.mol
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米托蒽醌甲磺酸盐化学性质
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储存条件:
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-20°C
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溶解度:
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Soluble in DMSO.
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形态:
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waxy solid
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颜色:
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Orange
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稳定性:
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Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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米托蒽醌甲磺酸盐性质、用途与生产工艺
Mitoquinone mesylate (MitoQ mesylate, MitoQ10, Mitoubiquinone) 是一种基于TPP的线粒体mitochondria靶向抗氧化剂，可阻断H2O2诱导的细胞内 ROS 反应并防止氧化损伤。
| Target | Value |
mitochondria
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ROS
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Mitoquinone (MitoQ) is a mitochondria-targeted antioxidant.The optimal doses for Mitoquinone (MitoQ) and DecylTPP treatment are selected from dose-response experiments during 4-h cold storage (CS). The potential protective benefits of Mitoquinone treatment against CS injury are tested initially using MitoSOX Red, a mitochondrial-targeted fluorescent dye that measures mitochondrial superoxide generation. Normal rat kidney (NRK) cells exposed to CS result in a ~2-fold increase in fluorescence due to mitochondrial superoxide compared with untreated cells. Mitoquinone offers significant protection against CS-induced mitochondrial superoxide generation; whereas the control compound DecylTPP does not offer any protection. Mitoquinone treatment markedly decreases mitochondrial superoxide generation, whereas kidneys treated with DecylTPP have comparable levels of mitochondrial superoxide to kidneys exposed to CS alone.
Mitoquinone (MitoQ) treatment significantly reduces pancreatic oedema and neutrophil infiltration. MitoQ dose-dependently increases serum amylase with an approximate doubling at the higher dose. MitoQ treatment nearly doubles lung MPO activity induced by Caerulein with a significant increase of serum IL-6 levels also evident at 10 mg/kg (dose 1).
米托蒽醌甲磺酸盐
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-100116A | 米托蒽醌甲磺酸盐
Mitoquinone mesylate | 845959-50-4 | 5mg | 1100元 |
| 2024/01/25 | HY-100116A | 米托蒽醌甲磺酸盐
Mitoquinone mesylate | 845959-50-4 | 10mM * 1mLin DMSO | 1643元 |
845959-50-4, 米托蒽醌甲磺酸盐 相关搜索:
- 药靶配体
- 产品
- 对照品-杂质对照品
- 甲磺酸米托醌(米托Q10)
- 米托醌甲磺酸盐
- 米托蒽醌甲磺酸盐
- 845959-50-4
- Mitoquinone (MitoQ10) mesylate
- Mitoquinone mesylate (MitoQ)
- Mitoquinone mesylate, ethanol solution
- Mitoquinol Mesylate
- MitoQ10 mesylate
- MitoQ mesylate
- Mitoquinone mesylate (Mitoquinone methanesulfonate
- 10-(4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)decyl-triphenylphosphanium,methanesulfonate
- MitoQ
- Mitoquinone mesylate