阿托伐他汀杂质A
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- CAS号:
- 433289-83-9
- 英文名:
- Atorvastatin Related Compound A
- 英文别名:
- USP Impurity A;Adrafinil Impurity 4;Atorvastatin calcium-1;Atorvastatin Impurity A;DESFLUORO IMPURITY(IMP-A);Atorvastatin EP IMpurity A;Atorvastatin Related CoMpound A;ATORVASTATIN DESFLUORO IMPURITY;Atorvastatin Calcium Impurity A;Desfluoro Atorvastatin SodiuM Salt
- 中文名:
- 阿托伐他汀杂质A
- 中文别名:
- 阿托伐他汀杂质A;阿托伐他汀钙杂质A;阿托伐他汀相关物质A;阿托伐他汀EP杂质A;阿托伐他汀杂质A(EP);阿托伐他汀相关化合物A(USP);阿托伐他汀相关物质A USP标准品;阿托伐他汀EP杂质ABCDEFGHJKL;阿托伐他汀EP杂质A钙盐(脱氟阿托伐他汀钙盐);阿托伐他汀杂质26 钙盐(阿托伐他汀EP杂质A 钙盐)
- CBNumber:
- CB22521022
- 分子式:
- C33H35CaN2O5+
- 分子量:
- 579.7194
- MOL File:
- 433289-83-9.mol
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阿托伐他汀杂质A化学性质
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熔点:
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150℃ (decomposition)
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溶解度:
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DMSO (Slightly), Methanol (Slightly)
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稳定性:
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Hygroscopic
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阿托伐他汀杂质A性质、用途与生产工艺
阿托伐他汀钙属于羟甲基戊二酰辅酶(HMG-CoA)还原酶抑制剂，它主要通过抑制肝脏内HMG-CoA还原酶来降低血浆中胆固醇和血清脂蛋白的浓度。主要适应症有原发性高胆固醇血症、混合性高血脂症以及家族性高胆固醇血症。阿托伐他汀钙作为全球畅销的降血脂药物，必须严格控制杂质的含量，去氟阿托伐他汀钙为其主要杂质，为确保用药安全，其制备过程中产生的杂质、去氟阿托伐他汀钙等均可引起不良反应。 全合成得到去氟阿托伐他汀钙,为阿托伐他汀产品质量分析及控制提供重要依据。
将[R,(R*,R*)]-2-(4-氟苯基)-β,α-二羟基-5-(1-甲基乙基)-3-苯基-[(苯胺基)-羟基]-1H-吡咯-1-庚酸钠盐溶液转入10L洁净干燥的反应釜中，再向釜中加入3L甲醇，升温至60℃-65℃，通过恒压滴液漏斗缓慢滴加乙酸钙溶液（乙酸钙溶液为150g一水合乙酸钙与700ml纯化水和700ml甲醇混合配制而得）。滴加结束后，在60℃-65℃下保温搅拌2小时。停止加热，冷却至5℃-10℃，保温搅拌1小时。抽滤，得白色滤饼，即为阿托伐他汀钙粗品。
将阿托伐他汀钙缩合物用流动相溶解后，负载在色谱柱上，然后用流动相洗脱分离，分段收集洗脱液，将含有去氟阿托伐他汀钙的洗脱液减压浓缩至干，浓缩液加入乙酸乙酯溶解，用饱和柠檬酸洗涤，有机相减压浓缩至干得到白色泡沫状固体，纯度为99.6％，经过质朴检测MS(ESI):[M+H]+:855，即为去氟阿托伐他汀钙。
阿托伐他汀杂质A
上下游产品信息
上游原料
下游产品
433289-83-9, 阿托伐他汀杂质A 相关搜索:
- 化工原料
- 杂质对照品
- 杂质
- 对照品-杂质对照品
- 111936
- C33H35N2O52Ca
- CaC33H36N2O52
- C66H70CaN4O10
- [R-(3R*,5R*)]-Β,Δ-二羟基-5-(1-甲基乙基)-2,3-二苯基-4-[(苯胺基)羰基]-1H-吡咯-1-庚酸钙盐(2:1)
- 阿托伐他汀杂质26 钙盐(阿托伐他汀EP杂质A 钙盐)
- 阿托伐他汀EP杂质A钙盐(脱氟阿托伐他汀钙盐)
- (3R,5R)-3,5-二羟基-7-(2-异丙基-4,5-二苯基-3-(苯基氨基甲酰基)-1H-吡咯-1-基)庚酸钙盐 (阿托伐他汀杂质)
- 去氟阿托伐他汀钙 (阿托伐他汀钙 2020药典杂质I)"
- 阿托伐他汀EP杂质ABCDEFGHJKL
- 阿托伐他汀钙杂质A([R-(3R*,5R*)]-Β,Δ-二羟基-5-(1-甲基乙基)-2,3-二苯基-4-[(苯胺基)羰基]-1H-吡咯-1-庚酸钙盐(2:1))
- 阿托伐他汀相关物质A USP标准品
- 阿托伐他汀相关化合物A(USP)
- 阿托伐他汀杂质A(EP)
- 阿托伐他汀EP杂质A
- 阿托伐他汀杂质A
- 阿托伐他汀相关物质A
- 阿托伐他汀钙杂质A
- [R-(3R*,5R*)]-Β,Δ-二羟基-5-(1-甲基乙基)-2,3-二苯基-4-[(苯胺基)羰基]-1H-吡咯-1-庚酸钙盐(2:1)
- 433289-83-9
- (3R,5R)-7-[3-(Phenylcarbamoyl)-2-isopropyl-4,5- diphenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid calcium salt
- (βR,δR)-β,δ-Dihydroxy-2-(1-methylethyl)-4,5-diphenyl-3-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic Acid Calcium Salt
- Adrafinil Impurity 4
- DESFLUORO IMPURITY(IMP-A)
- (3R,5R)-3,5-Dihydroxy-7-(2-isopropyl-4,5-diphenyl-3-(phenylcarbamoyl)-1H-pyrrol-1-yl)heptanoate, calcium salt (2:1)
- (3R,5R)-3,5-Dihydroxy-7-(2-isopropyl-4,5-diphenyl-3-(phenylcarbamoyl)-1H-pyrrol-1-yl)heptanoic acid, calcium salt (Atorvastatin Impurity)
- Atorvastatin Impurity 26 Calcium Salt (Atorvastatin EP Impurity A Calcium Salt)
- USP Impurity A
- Atorvastatin calcium-1
- (3R,5R)-3,5-dihydroxy-7-(2-isopropyl-
- Atorvastatin Calcium Hydrate impurity 22
- Atorvastatin USP Related Compound A
- Atorvastatin Related Compound A (Desfluoro impurity, or (3R,5R)-7-[3-(phenylcarbamoyl)-2-isopropyl- (1044527)
- Atorvastatin EP Impurity AQ: What is
Atorvastatin EP Impurity A Q: What is the CAS Number of
Atorvastatin EP Impurity A Q: What is the storage condition of
Atorvastatin EP Impurity A Q: What are the applications of
Atorvastatin EP Impurity A
- "Defluoridated atorvastatin calcium" Atorvastatin calcium 2020 Pharmacopoeia impurity I)“
- Defluorocarbon atorvastatin calcium
- USP Atorvastatin Related Compound A
- Atorvastatin EP ImpurityABCDEFGHJKL
- Atorvastatin Calcium Impurity A
- Atorvastatin impurity 4/Atorvastatin EP Impurity A Calcium Salt/Defluoro Atorvastatin Calcium Salt/(3R,5R)-3,5-Dihydroxy-7-(2-isopropyl-4,5-diphenyl-3-(phenylcarbamoyl)-1H-pyrrol-1-yl)heptanoate, calcium salt (2:1)
- Calcium bis{(3R,5R)-3,5-dihydroxy-7-[2-isopropyl-4,5-diphenyl-3-(phenylcarbamoyl)-1H-pyrrol-1-yl]heptanoate}
- ((3R,5R)-3,5-dihydroxy-7-(2-isopropyl-4,5-diphenyl-3-
(phenylcarbamoyl)-1H-pyrrol-1-yl)heptanoate) calcium(II)
- (βR,δR)-β,δ-Dihydroxy-2-(1-methylethyl)-4,5-diphenyl-3-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic Acid Calcium Salt (2:1)
- calciuM (3R,5R)-3,5-dihydroxy-7-(2-isopropyl-4,5-diphenyl-3-(phenylcarbaMoyl)-1H-pyrrol-1-yl)heptanoate
- Desfluoro Atorvastatin SodiuM Salt
- Desfluoro iMpurity, or (3R,5R)-7-[3-(phenylcarbaMoyl)-2-isopropyl-4,5-diphenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid calciuM salt
- Atorvastatin Related CoMpound A
- Atorvastatin Related Compound A (20 mg) (Desfluoro impurity,
or (3R,5R)-7-[3-(phenylcarbamoyl)-2-isopropyl-4,5-
diphenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid
calcium salt)
- ATORVASTATIN DESFLUORO IMPURITY
- Calcium (3R,5R)-3,5-dihydroxy-7-(2-isopropyl-4,5-diphenyl-3-(phenylcarbamoyl)-1H-pyrrol-1-yl)h
- (βR,δR)-β,δ-Dihydroxy-2-(1-methylethyl)-4,5-diphenyl-3-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemicalcium salt
- Atorvastatin Impurity A
- (betaR,deltaR)-beta,delta-Dihydroxy-2-(1-methylethyl)-4,5-diphenyl-3-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid calcium salt (2:1)
- Desfluoro Atorvastatin Calcium Salt