1-【4-(二苯甲基)-1-哌嗪基】-3,3-二苯基-1-丙酮
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- CAS号:
- 41332-24-5
- 英文名:
- 1-[4-(DiphenylMethyl)-1-piperazinyl]-3,3-diphenyl-1-propanone
- 英文别名:
- Z160;39-1B4;CS-2371;NP 118809;NP118809 (39-1B4;39-1B4; NP-118809;NP 118809;NP118809;1-(DiphenylMethyl)-4-(1-oxo-3,3-diphenylpropyl)piperazine;Piperazine, 1-(diphenylmethyl)-4-(1-oxo-3,3-diphenylpropyl)-;1-[4-(DiphenylMethyl)-1-piperazinyl]-3,3-diphenyl-1-propanone
- 中文名:
- 1-【4-(二苯甲基)-1-哌嗪基】-3,3-二苯基-1-丙酮
- 中文别名:
- 1-(二苯基甲基)-4-(1-氧代-3,3-二苯基丙基)哌嗪;1-【4-(二苯甲基)-1-哌嗪基】-3,3-二苯基-1-丙酮;1-[4-(二苯基甲基)-1-哌嗪]-3,3-二苯基-1-丙酮;NP118809,N 型钙通道 (N-TYPE CALCIUM CHANNEL) 阻滞剂
- CBNumber:
- CB22544418
- 分子式:
- C32H32N2O
- 分子量:
- 460.61
- MOL File:
- 41332-24-5.mol
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1-【4-(二苯甲基)-1-哌嗪基】-3,3-二苯基-1-丙酮化学性质
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沸点:
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618.9±55.0 °C(Predicted)
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密度:
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1.142±0.06 g/cm3(Predicted)
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储存条件:
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Sealed in dry,Room Temperature
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溶解度:
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DMSO : 50 mg/mL (108.55 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
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形态:
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Powder
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酸度系数(pKa):
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5.99±0.10(Predicted)
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1-【4-(二苯甲基)-1-哌嗪基】-3,3-二苯基-1-丙酮性质、用途与生产工艺
NP118809 是一种有效的 N 型钙通道 (N-type calcium channel) 阻滞剂,IC50 值为 0.11 μM;同时可较弱地抑制 L 型钙通道 (L-type calcium channel),IC50 值为 12.2 μM。
N-Type Ca
2+
Channel
0.11 μM (IC
50
)
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L-type calcium channel
12.2 μM (IC
50
)
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NP118809 is a potent N-type calcium channel blocker, with an IC
50
of 0.11 μM; also inhibits L-type calcium channel with an IC
50
of 12.2 μM. NP118809 inhibits the hERG potassium channel in HEK cells, with an IC
50
of 7.4 μM.
NP118809 (25 mg/kg, i.p.) shows significant analgesic activity in the phase IIA portions of the rat formalin model. NP118809 (30 mg/kg, p.o.) results in 80.3% inhibition of mechanical allodynia and 96.3% inhibition of thermal hyperalgesia in the rat spinal nerve ligation model.
1-【4-(二苯甲基)-1-哌嗪基】-3,3-二苯基-1-丙酮
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更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/01/25 | HY-14462 | 1-【4-(二苯甲基)-1-哌嗪基】-3,3-二苯基-1-丙酮 NP118809 | 41332-24-5 | 100mg | 744元 |
2024/01/25 | HY-14462 | 1-【4-(二苯甲基)-1-哌嗪基】-3,3-二苯基-1-丙酮 NP118809 | 41332-24-5 | 10mM * 1mLin DMSO | 818元 |
1-【4-(二苯甲基)-1-哌嗪基】-3,3-二苯基-1-丙酮
生产厂家
41332-24-5, 1-【4-(二苯甲基)-1-哌嗪基】-3,3-二苯基-1-丙酮 相关搜索:
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Heterocycles
- Aromatics
- 合成有机化合物配体
- 膜转运
- 离子通道
- NP118809,N 型钙通道 (N-TYPE CALCIUM CHANNEL) 阻滞剂
- 1-[4-(二苯基甲基)-1-哌嗪]-3,3-二苯基-1-丙酮
- 1-(二苯基甲基)-4-(1-氧代-3,3-二苯基丙基)哌嗪
- 1-【4-(二苯甲基)-1-哌嗪基】-3,3-二苯基-1-丙酮
- 41332-24-5
- 39-1B4; NP-118809
- NP 118809;NP118809
- CS-2371
- NP118809 (39-1B4
- 1-Propanone, 1-[4-(diphenylmethyl)-1-piperazinyl]-3,3-diphenyl-
- Piperazine, 1-(diphenylmethyl)-4-(1-oxo-3,3-diphenylpropyl)-
- Z160
- NP 118809
- 39-1B4
- 1-(DiphenylMethyl)-4-(1-oxo-3,3-diphenylpropyl)piperazine
- 1-[4-(DiphenylMethyl)-1-piperazinyl]-3,3-diphenyl-1-propanone