6-[4-(1-氨基环丁基)苯基]-5-苯基-3-吡啶甲酰胺
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- CAS号:
- 1357158-81-6
- 英文名:
- AZD-26
- 英文别名:
- AZD-26;AKT-IN-1;AZD-26 ≥95%;AKT inhibitor 1;AZD-26(AKT-IN-1）;AZD-26;AZD 26;AZD26;6-(4-(1-aminocyclobutyl)phenyl)-5-phenylnicotinamide;PKB,inhibit,Akt,Protein kinase B,AKT IN 1,AKTIN1,Inhibitor;6-[4-(1-Aminocyclobutyl)phenyl]-5-phenyl-3-pyridinecarboxamide;3-PyridinecarboxaMide, 6-[4-(1-aMinocyclobutyl)phenyl]-5-pheny
- 中文名:
- 6-[4-(1-氨基环丁基)苯基]-5-苯基-3-吡啶甲酰胺
- 中文别名:
- 6-[4-(1-氨基环丁基)苯基]-5-苯基-3-吡啶甲酰胺
- CBNumber:
- CB22642549
- 分子式:
- C22H21N3O
- 分子量:
- 343.42
- MOL File:
- 1357158-81-6.mol
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6-[4-(1-氨基环丁基)苯基]-5-苯基-3-吡啶甲酰胺化学性质
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沸点:
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496.4±45.0 °C(Predicted)
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密度:
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1.210±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO : 25 mg/mL (72.80 mM)
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酸度系数(pKa):
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14.75±0.50(Predicted)
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6-[4-(1-氨基环丁基)苯基]-5-苯基-3-吡啶甲酰胺性质、用途与生产工艺
AKT-IN-1 是一种变构 AKT 抑制剂，IC50 为 1.042 μM。
AKT-IN-1 is able to potently inhibit phosphorylation of AKT in cells at both Thr308 and Ser473, with IC
50
s of 0.422 and 0.322 μM, respectively. AKT-IN-1 inhibits the phosphorylation of ribosomal protein S6, a downstream effector of the PI3K-AKT pathway. AKT-IN-1 potently inhibits the phosphorylation of PRAS40.
The effects of AKT-IN-1 (Compound 26) in vivo are characterized by measuring the pharmacodynamic activity of AKT-IN-1 in a BT474c breast adenocarcinoma xenograft model. Following acute doses of 100 and 200 mg/kg, AKT-IN-1 potently inhibits the phosphorylation of its downstream substrate GSK3β as well as the phosphorylation of AKT (Ser473), with a potency consistent with its pharmacokinetic profile. The in vivo activity of AKT-IN-1 is further characterized by measuring the effects on the growth of tumor cell xenografts. Continuous (daily) oral dosing of AKT-IN-1 (100 and 200 mg/kg) to nude mice bearing BT474c breast adenocarcinoma xenografts results in inhibition of tumor growth in a dose-dependent manner. When dosed at 200 mg/kg daily, AKT-IN-1 causes significant tumor growth inhibition.
6-[4-(1-氨基环丁基)苯基]-5-苯基-3-吡啶甲酰胺
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-18296 | AKT-IN-1 | | 1 mg | 1142元 |
| 2024/01/25 | HY-18296 | 6-[4-(1-氨基环丁基)苯基]-5-苯基-3-吡啶甲酰胺
AKT-IN-1 | 1357158-81-6 | 5mg | 2500元 |
6-[4-(1-氨基环丁基)苯基]-5-苯基-3-吡啶甲酰胺
生产厂家
1357158-81-6, 6-[4-(1-氨基环丁基)苯基]-5-苯基-3-吡啶甲酰胺 相关搜索:
- 药靶配体
- 6-[4-(1-氨基环丁基)苯基]-5-苯基-3-吡啶甲酰胺
- 1357158-81-6
- AZD-26(AKT-IN-1）
- 3-Pyridinecarboxamide, 6-[4-(1-aminocyclobutyl)phenyl]-5-phenyl-
- PKB,inhibit,Akt,Protein kinase B,AKT IN 1,AKTIN1,Inhibitor
- AKT inhibitor 1
- 6-(4-(1-aminocyclobutyl)phenyl)-5-phenylnicotinamide
- AZD-26;AZD 26;AZD26
- AZD-26 ≥95%
- AKT-IN-1
- 6-[4-(1-Aminocyclobutyl)phenyl]-5-phenyl-3-pyridinecarboxamide
- 3-PyridinecarboxaMide, 6-[4-(1-aMinocyclobutyl)phenyl]-5-pheny
- AZD-26