YF-2
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- CAS号:
- 1311423-89-8
- 英文名:
- BenzaMide, N-[4-chloro-3-(trifluoroMethyl)phenyl]-2-[2-(diMethylaMino)ethoxy]-6-ethoxy-
- 英文别名:
- YF-2;YF 2;YF 2,HATs,inhibit,HAT,Histone Acetyltransferase,Inhibitor,YF2,YF-2;N-[4-chloro-3-(trifluoromethyl)phenyl]-2-[2-(dimethylamino)ethoxy]-6-ethoxybenzamide;BenzaMide, N-[4-chloro-3-(trifluoroMethyl)phenyl]-2-[2-(diMethylaMino)ethoxy]-6-ethoxy-
- 中文名:
- YF-2
- 中文别名:
- 化合物YF-2
- CBNumber:
- CB22668406
- 分子式:
- C20H22ClF3N2O3
- 分子量:
- 430.85
- MOL File:
- 1311423-89-8.mol
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YF-2化学性质
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沸点:
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460.8±45.0 °C(Predicted)
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密度:
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1.285±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml
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形态:
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A crystalline solid
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酸度系数(pKa):
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11.75±0.70(Predicted)
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YF-2性质、用途与生产工艺
YF-2 是一种高选择性的、可血脑屏障渗透的 histone acetyltransferase (HAT) 的激活剂。在体外测定中，YF-2 具有针对CBP、PCAF和GCN5的活性，EC50 分别为2.75 μM、29.04 μM和49.3 μM。YF-2 也增加p300活性。
| Target | Value |
HAT
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p300
()
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CBP
(Cell-based assay)
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2.75 μM(EC50)
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PCAF
(Cell-based assay)
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29.04 μM(EC50)
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GCN5
(Cell-based assay)
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49.3 μM(EC50)
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YF-2 (0.03, 0.1, 0.25, 0.5, 1, 2.5, 5, 15, 40 and 80 μM, 72 hours) inhibits the preliferation of U251, CCRF-CEM, Hs578T, NCI-ADR-RES cells.
YF-2 (20 mg/kg, 2 hours befor electric shock or 5 mg/kg, 30 min before the electric shock, i.p.) rescues the defect in contextual memory in mice, and shows no effect on contextual memory alone at 20 mg/kg in mice.
YF-2
上下游产品信息
上游原料
下游产品
1311423-89-8, YF-2 相关搜索:
- API
- 药靶配体
- C20H22ClF3N2O3
- 化合物YF-2
- 1311423-89-8
- YF 2,HATs,inhibit,HAT,Histone Acetyltransferase,Inhibitor,YF2,YF-2
- N-[4-chloro-3-(trifluoromethyl)phenyl]-2-[2-(dimethylamino)ethoxy]-6-ethoxybenzamide
- YF-2;YF 2
- BenzaMide, N-[4-chloro-3-(trifluoroMethyl)phenyl]-2-[2-(diMethylaMino)ethoxy]-6-ethoxy-