去氟甲基丙酸氟替卡松二硫化物
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- CAS号:
- 201812-64-8
- 英文名:
- DesfluoroMethyl Fluticasone Propionate Disulfide
- 英文别名:
- Fluticasone Propionate EP Impurity H;Fluticasone EP Imp H;Propionate Impurity H;Fluticasone Impurity 9;Fluticasone Disulphane Impurity;fluticasone propionate impurity EP-ZH;Fluticasone Propionate Disulfide Dimer Impurity;DesfluoroMethyl Fluticasone Propionate Disulfide;Fluticasone Impurity 8(Fluticasone EP Impurity H);17,17′-(disulfanediyldicarbonyl)bis(6α,9-difluoro-11β hydroxy- 16α-methyl-3-oxoandrosta-1,4-dien-17α-yl)dipropanoate
- 中文名:
- 去氟甲基丙酸氟替卡松二硫化物
- 中文别名:
- 氟替卡松杂质9;丙酸氟替卡松杂质H3;丙酸氟替卡松EP杂质H;氟替卡松欧洲药典杂质H;氟替卡松杂质H(EP);去氟甲基丙酸氟替卡松二硫化物;去氟甲基氟替卡松丙酸酯二硫化物;氟替卡松杂质8(氟替卡松EP杂质H);氟替卡松杂质-去氟甲基丙酸氟替卡松二硫化物;氟替卡松杂质9(暂停使用,改用C4X-165016)
- CBNumber:
- CB22695792
- 分子式:
- C48H58F4O10S2
- 分子量:
- 935.09
- MOL File:
- 201812-64-8.mol
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去氟甲基丙酸氟替卡松二硫化物化学性质
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熔点:
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>200°C
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沸点:
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905.0±75.0 °C(Predicted)
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密度:
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1.38±0.1 g/cm3(Predicted)
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储存条件:
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Refrigerator
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溶解度:
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Chloroform (Slightly), DMSO (Slightly)
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酸度系数(pKa):
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12.20±0.70(Predicted)
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形态:
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Solid
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颜色:
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Off-White to Light Yellow
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去氟甲基丙酸氟替卡松二硫化物性质、用途与生产工艺
去氟甲基丙酸氟替卡松二硫化物为丙酸氟替卡松的合成中间体，主要用作医药中间体，用于实验室研发过程和化工医药合成过程中。
去氟甲基丙酸氟替卡松二硫化物为丙酸氟替卡松制备过程中生成的杂质：第一步涉及在氟米松中C-17上的羟甲基的氧化裂解，化学上称为6α，9α-二氟-11β，17α，21-三羟基-16。α-甲基-雄甾-1,4-二烯-3,20-二酮，通过高碘酸得到6α，9α-二氟-11β，17α-二羟基-16α-甲基-雄甾-1,4-二烯-3-酮-17β-羧酸2.使用N，N'-羰基二咪唑（CDI）在二甲基甲酰胺（DMF）中活化化合物2的羧基随后用H2S处理得到6α，9α-二氟-11β，1-7α-二羟基-16α-甲基-3-氧代-雄甾-1,4-二烯-17使用丙酰氯和三乙胺（TEA）将化合物3的C-17羟基酯化，得到6α，9α-二氟-11β-羟基-16[甲基]-[化学式3]的C-17羟基。α-甲基-17α-丙酰氧基-3-氧代-雄甾-1,4-二烯-17β-硫代甲酸4.使用NaHCO3和二甲基乙酰胺将化合物4与溴氯甲烷烷基化ide（DMAc）得到S-氯甲基-6α，9α-二氟-11β-羟基-16α-甲基-17α-丙酰氧基-3-氧代-雄甾-1,4-二烯-17β-硫代磷酸酯。
去氟甲基丙酸氟替卡松二硫化物
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201812-64-8, 去氟甲基丙酸氟替卡松二硫化物 相关搜索:
氟替卡松杂质 氟替卡松丙酸酯中间体E 丙酸氟替卡松杂质 氟替卡松杂质 氟替卡松 5-氯-2-甲基-4-异噻唑啉-3-酮 糠酸氟替卡松 氟替卡松杂质 氟替卡松丙酸酯 (6Α,11Β,16Α,17Α)-(6'Α,11'Β,16'Α,17'Α)-17,17'-(三硫代二羰基)双[6,9-二氟-11-羟基-16-甲基-17-(1-氧代丙氧基)-雄甾-1,4-二烯-3-酮 氟替卡松杂质F 氟替卡松二聚物杂质 6Α,9Α-二氟-11Β-羟基-16Α-甲基-3-氧代-17Α-(丙酰氧基)雄甾-1,4-二烯-17Β-羧酸 氟替卡松杂质B 氟替卡松杂质D 乙酰化氟替卡松 氟米松酸 氟替卡松杂质E
- Pharmaceuticals, Intermediates & Fine Chemicals, Steroids
- 182-丙酸氟替卡松
- 杂质对照品
- 对照品-杂质对照品
- C48H58F4O10S2
- 氟替卡松杂质8(氟替卡松EP杂质H)
- (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-二氟-11-羟基-10,13,16-三甲基-3-氧代-17-(丙酰氧基)-6,7,8,9,10,11,12,13,14,15,16,17-十二氢-3H-环戊烷[A]菲-17-羧基二硫氧基酐 (丙酸氟替卡松杂质)
- 氟替卡松杂质9(暂停使用,改用C4X-165016)
- 丙酸氟替卡松EP杂质H
- 氟替卡松杂质9
- DESFLUOROMETHYL FLUTICASONE PROPIONATE DISULFIDE; FLUTICASONE PROPIONATE EP IMPURITY H; FLUTICASONE PROPIONATE DISULFIDE DIMER IMPURITY
- 氟替卡松欧洲药典杂质H
- 去氟甲基氟替卡松丙酸酯二硫化物
- 氟替卡松杂质H(EP)
- 丙酸氟替卡松杂质H3
- 氟替卡松杂质-去氟甲基丙酸氟替卡松二硫化物
- 去氟甲基丙酸氟替卡松二硫化物
- 201812-64-8
- fluticasone propionate impurity EP-ZH
- (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-Difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(propionyloxy)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic dithioperoxyanhydride (Fluticasone Propionate Impurity)
- (6α,11β,16α,17α)-(6'α,11'β,16'α,17'α)-17,17'-(Dithiodicarbonyl)bis[6,9-difluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)androsta-1,4-dien-3-one
- Fluticasone Propionate EP Impurity H
- 17,17′-(disulfanediyldicarbonyl)bis(6α,9-difluoro-11β hydroxy- 16α-methyl-3-oxoandrosta-1,4-dien-17α-yl)dipropanoate
- Fluticasone EP Imp H
- Fluticasone Propionate EP Impurity H/Fluticasone Disulphane Impurity/Desfluoromethyl Fluticasone Propionate Disulfide/17,17′-(Disulphanediyldicarbonyl)bis(6α,9-difluoro-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-dien-17α-yl) dipropanoate
- Propionate Impurity H
- Fluticasone Impurity 8(Fluticasone EP Impurity H)
- Fluticasone Impurity 9
- DesfluoroMethyl Fluticasone Propionate Disulfide
- Fluticasone Disulphane Impurity
- Fluticasone Propionate Disulfide Dimer Impurity
- Androsta-1,4-dien-3-one, 17,17'- (dithiodicarbonyl)bis[6,9- difluoro-11-hydroxy-16-Methyl-17-(1-oxopropoxy)-, (6α,11β, 16α,17α)-(6'α,11'β,16'α,17'α)-