STF 083010
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- CAS号:
- 307543-71-1
- 英文名:
- STF 083010
- 英文别名:
- CS-2901;CS-2595;STF 083010;STF-083010;STF083010;STF 083010;N-[(2-Hydroxy-1-naphthalenyl)methylene]-2-thiophenesulfonamide;N-((2-Hydroxynaphthalen-1-yl)methylene)thiophene-2-sulfonamide;2-Thiophenesulfonamide, N-[(2-hydroxy-1-naphthalenyl)methylene]-;(E)-N-((2-hydroxynaphthalen-1-yl)methylene)thiophene-2-sulfonamide;STF 083010,STF-083010,Inositol requiring enzyme 1,Inhibitor,inhibit,IRE1
- 中文名:
- STF 083010
- 中文别名:
- STF-083010游离态;英文名称:STF 083010;IRE1抑制剂(STF-083010);N-((2-羟基萘-1-基)亚甲基)噻吩-2-磺酰胺;N-[(2-羟基-1-萘基)亚甲基]-2-噻吩磺酰胺
- CBNumber:
- CB22701433
- 分子式:
- C15H11NO3S2
- 分子量:
- 317.38
- MOL File:
- 307543-71-1.mol
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STF 083010化学性质
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熔点:
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199-201°C
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沸点:
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548.4±56.0 °C(Predicted)
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密度:
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1.40±0.1 g/cm3(Predicted)
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储存条件:
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-20°C
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溶解度:
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DMSO: soluble5mg/mL (clear solution)
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酸度系数(pKa):
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7.31±0.50(Predicted)
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形态:
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powder
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颜色:
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light yellow to yellow-green
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稳定性:
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Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
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STF 083010性质、用途与生产工艺
STF-083010 是一种 IRE1α 特异性抑制剂。在内质网应激后，STF-083010 抑制 Ire1 内切核酸酶活性，而不影响其激酶活性。
STF-083010 shows cytostatic and cytotoxic activity in a dose- and time-dependent manner. Treatment with STF-083010 shows significant antimyeloma activity in model human multiple myeloma (MM) xenografts. RPMI 8226 human MM cells grown as tumor xenografts are treated in NSG mice. Intraperitoneal injection of STF-083010 alone (day 1, day 8) significantly inhibits the growth of these tumors. STF-083010 is an IRE1α-specific inhibitor. Four pancreatic cancer cell lines (Panc0403, Panc1005, BxPc3, MiaPaCa2) are treated with different combination of Bortezomib (10 or 50 nM) and STF (10 or 50 μM). The normalized isobologram analysis demonstrates synergistic activity between 10 μM STF and either 10 or 50 nM bortezomib in all four cell lines. Moreover, a higher concentration of STF (50 μM) attains synergy after addition of bortezomib either at a concentration of 10 nM when tested against BxPc3 cells, at a concentration of 50 nM against Panc1005 cells, and at either 10 or 50 nM against Panc0403 cells. STF-083010 (50 μM) suppresses the growth of p53-deficient human cancer cells.
Treatment with STF-083010 reduces the viability of HCT116
p53
-/-
cells by approximately 20% compared with that of HCT116
p53
-/-
cells. Administration of STF-083010 to tumors induced by HCT116
p53
-/-
cells significantly reduces tumor volume and weight by 75% and 73% at the endpoint, respectively.
STF 083010
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/01/25 | HY-15845 | STF-083010 | | 1 mg | 250元 |
| 2024/01/25 | HY-15845 | STF 083010
STF-083010 | 307543-71-1 | 5mg | 550元 |
307543-71-1, STF 083010 相关搜索:
- Inhibitors
- 天然产物
- 化工
- 细胞生物学试剂
- 小分子抑制剂，天然产物
- N-((2-羟基萘-1-基)亚甲基)噻吩-2-磺酰胺
- 英文名称:STF 083010
- STF-083010游离态
- N-[(2-羟基-1-萘基)亚甲基]-2-噻吩磺酰胺
- IRE1抑制剂(STF-083010)
- 307543-71-1
- STF 083010,STF-083010,Inositol requiring enzyme 1,Inhibitor,inhibit,IRE1
- N-((2-Hydroxynaphthalen-1-yl)methylene)thiophene-2-sulfonamide
- 2-Thiophenesulfonamide, N-[(2-hydroxy-1-naphthalenyl)methylene]-
- CS-2901
- CS-2595
- STF-083010;STF083010;STF 083010
- N-[(2-Hydroxy-1-naphthalenyl)methylene]-2-thiophenesulfonamide
- (E)-N-((2-hydroxynaphthalen-1-yl)methylene)thiophene-2-sulfonamide
- STF 083010