CS-2649
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- CAS号:
- 80306-38-3
- 英文名:
- AR7
- 英文别名:
- AR7;ERBA;ERB-T-1;CS-2649;c-ERBA-1;MGC43240;AR7;AR 7;MGC000261;AR 7(RARα agonist);Atypical retinoid 7
- 中文名:
- CS-2649
- 中文别名:
- 化合物AR7;7-氯-3-(P-甲苯基)-2H-苯并[B] [1,4]恶嗪
- CBNumber:
- CB22714659
- 分子式:
- C15H12ClNO
- 分子量:
- 257.71
- MOL File:
- 80306-38-3.mol
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CS-2649化学性质
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储存条件:
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Sealed in dry,2-8°C
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溶解度:
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DMSO: soluble20mg/mL, clear
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形态:
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powder
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颜色:
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white to beige
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稳定性:
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Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
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CS-2649性质、用途与生产工艺
ar7是CMA的助推器，用于维甲酸衍生物介导的伴侣细胞自噬的化学调节的生物学研究。
AR7是视黄酸受体α(RARα)拮抗剂。
Treatment with RARA antagonist, AR7 (20 μM; for 16 h), increased lysosomal activity in WT and LRRK2
R1441G
KI mutant MEFs.
Chaperone-mediated autophagy (CMA) contributes to cellular quality control and the cellular response to stress through the selective degradation of cytosolic proteins in lysosomes. Decrease in CMA activity occurs in aging and in age-related disorders. Signaling through the retinoic acid receptor alpha (RARα) inhibits CMA. AR7, an RARα antagonist, significantly activates CMA activity in mouse fibroblasts. A marked increase in CMA-activating potency is found when AR7 and GR1 are combined, supporting their cooperative effect. Treatment with the transcriptional repressor Actinomycin D partially reduces the stimulatory effect of AR7 on CMA, consistent with transcriptional changes contributing to the upregulation of CMA.
CS-2649
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-101106 | AR7 | | 1 mg | 272元 |
| 2024/01/25 | HY-101106 | CS-2649
AR7 | 80306-38-3 | 5mg | 600元 |
80306-38-3, CS-2649 相关搜索:
- 药靶配体
- 化工试剂
- 原料药及中间体
- 化合物AR7
- 7-氯-3-(P-甲苯基)-2H-苯并[B] [1,4]恶嗪
- 80306-38-3
- receptor,AR 7,CMA,Retinoid X receptors,Retinoic acid receptors,retinoic,macroautophagy,inhibit,AR-7,AR7,acid,RAR/RXR,Inhibitor
- AR7;AR 7
- CS-2649
- Reaxys ID: 20039175
- 2H-1,4-Benzoxazine, 7-chloro-3-(4-methylphenyl)-
- AR 7(RARα agonist)
- TR, α1, GST tagged human
- MGC43240
- MGC000261
- ERB-T-1
- ERBA
- c-ERBA-1
- Thyroid Hormone receptor,α1 human
- Atypical retinoid 7
- 7-Chloro-3-p-tolyl-2H-benzo[b][1,4]oxazine
- 7-Chloro-3-(4-methylphenyl)-2H-1,4-benzoxazine
- AR7