FRAX1036
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- CAS号:
- 1432908-05-8
- 英文名:
- FRAX1036
- 英文别名:
- CS-2271;FRAX1036;FRAX-1036;FRAX 1036;FRAX1036 (Free base);FRAX 1036,Inhibitor,p21 activated kinases,PAK,FRAX1036,inhibit,FRAX-1036;6-(2-Chloro-4-(6-methylpyrazin-2-yl)phenyl)-8-ethyl-2-((2-(1-methylpiperidin-4-yl)ethyl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one;Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-[2-chloro-4-(6-methyl-2-pyrazinyl)phenyl]-8-ethyl-2-[[2-(1-methyl-4-piperidinyl)ethyl]amino]-
- 中文名:
- FRAX1036
- 中文别名:
- 化合物FRAX1036;FRAX1036游离态;PAK小分子抑制剂(FRAX1036);6-(2-氯-4-(6-甲基吡嗪-2-基)苯基)-8-乙基-2-((2-(1-甲基哌啶-4-基)乙基)氨基)吡啶并[2,3-D]嘧啶-7(8H)-酮
- CBNumber:
- CB23122927
- 分子式:
- C28H32ClN7O
- 分子量:
- 518.05
- MOL File:
- 1432908-05-8.mol
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FRAX1036化学性质
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沸点:
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669.8±65.0 °C(Predicted)
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密度:
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1?+-.0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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形态:
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crystalline solid
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酸度系数(pKa):
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9.46±0.10(Predicted)
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FRAX1036性质、用途与生产工艺
FRAX1036 是一种 PAK 抑制剂，对 PAK1，PAK2 和 PAK4 的 Ki 值分别为 23.3 nM，72.4 nM 和 2.4 μM。
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PAK1
23.3 nM (Ki)
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PAK2
72.4 nM (Ki)
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PAK4
2.4 μM (Ki)
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FRAX1036 is a PAK inhibitor with K
i
s of 23.3 nM, 72.4 nM, and 2.4 μM for PAK1, PAK2 and PAK4, respectively. FRAX1036 (2.5 μM) incombination with docetaxel alters stathmin phosphorylation, induces the apoptotic marker cleaved PARP and increases kinetics of apoptosis in MDA-MB-175 and HCC2911 cells; also alters microtubule organization, mitosis and cell fate in U2OS cells. Moreover, FRAX1036 shows significantly effective inhibition on U2OS cells. FRAX1036 (10 μM) affects the proliferation of non-small cell lung cancer (NSCLC) cells when added to KRAS prenylation inhibitors.
FRAX1036
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-19538 | FRAX1036
FRAX1036 | 1432908-05-8 | 1mg | 600元 |
| 2024/01/25 | HY-19538 | FRAX1036
FRAX1036 | 1432908-05-8 | 5mg | 1100元 |
1432908-05-8, FRAX1036 相关搜索:
- 药靶配体
- 细胞生物学试剂
- 抑制剂
- C28H32ClN7O
- 6-(2-氯-4-(6-甲基吡嗪-2-基)苯基)-8-乙基-2-((2-(1-甲基哌啶-4-基)乙基)氨基)吡啶并[2,3-D]嘧啶-7(8H)-酮
- 化合物FRAX1036
- FRAX1036游离态
- PAK小分子抑制剂(FRAX1036)
- 1432908-05-8
- FRAX 1036,Inhibitor,p21 activated kinases,PAK,FRAX1036,inhibit,FRAX-1036
- 6-(2-Chloro-4-(6-methylpyrazin-2-yl)phenyl)-8-ethyl-2-((2-(1-methylpiperidin-4-yl)ethyl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one
- Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-[2-chloro-4-(6-methyl-2-pyrazinyl)phenyl]-8-ethyl-2-[[2-(1-methyl-4-piperidinyl)ethyl]amino]-
- CS-2271
- FRAX-1036;FRAX 1036
- FRAX1036 (Free base)
- FRAX1036