158959-32-1
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- CAS号:
- 158959-32-1
- 英文名:
- SC57666
- 英文别名:
- SC57666;SC57666,SC-57666;Benzene, 1-fluoro-4-[2-[4-(methylsulfonyl)phenyl]-1-cyclopenten-1-yl]-
- 中文名:
- 158959-32-1
- 中文别名:
- 化合物SC57666;化合物 T12860
- CBNumber:
- CB23339710
- 分子式:
- C18H17FO2S
- 分子量:
- 316.39
- MOL File:
- 158959-32-1.mol
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158959-32-1化学性质
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熔点:
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146-147 °C
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沸点:
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472.1±45.0 °C(Predicted)
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密度:
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1.253±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: ≥ 100 mg/mL (316.07 mM)
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158959-32-1性质、用途与生产工艺
SC57666是选择性的 COX2 抑制剂，IC50 值为26 nM。
SC57666 inhibits COX2 with an IC
50
of 3.2±0.8 nM in CHO cells stably transfected with human COX isozymes, with 1000 fold or more selectivity over COX1 (IC
50
=6000±1900 nM).
SC57666 has been shown to be orally active (ED
50
=1.7 mpk) in the adjuvant-induced arthritis model. No gastric lesions are observed in mice after 5 h when SC57666 is administered intragastrically at 600 mpk. No intestinal damage is observed in rats after 72 h when SC57666 is administered intragastrically at 200 mpk.
158959-32-1
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-U00129 | 158959-32-1
SC57666 | 158959-32-1 | 1mg | 2800元 |
| 2024/01/25 | HY-U00129 | 158959-32-1
SC57666 | 158959-32-1 | 5mg | 5800元 |
158959-32-1, 158959-32-1 相关搜索:
- C18H17FO2S
- 化合物SC57666
- 化合物 T12860
- 158959-32-1
- SC57666,SC-57666
- Benzene, 1-fluoro-4-[2-[4-(methylsulfonyl)phenyl]-1-cyclopenten-1-yl]-
- SC57666