1435786-04-1
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- CAS号:
- 1435786-04-1
- 英文名:
- GLYX13
- 英文别名:
- Rapastinel Trifluoroacetate;GLYX 13,inhibit,Rapastinel Trifluoroacetate,GLYX13,GLYX-13,Inhibitor,Rapastinel,Ionotropic glutamate receptors,iGluR
- 中文名:
- 1435786-04-1
- 中文别名:
- 化合物RAPASTINEL TRIFLUOROACETATE
- CBNumber:
- CB23339886
- 分子式:
- C20H32F3N5O8
- 分子量:
- 527.5
- MOL File:
- 1435786-04-1.mol
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1435786-04-1化学性质
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储存条件:
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Store at -20°C
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溶解度:
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DMSO : 125 mg/mL (236.97 mM)
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1435786-04-1性质、用途与生产工艺
Rapastinel Trifluoroacetate (GLYX-13 Trifluoroacetate) 是一种具有甘氨酸位点部分激动剂性质的 NMDA 受体调节剂。Rapastinel Trifluoroacetate 有潜力用于抑郁症的研究
Rapastinel Trifluoroacetate is an NMDA receptor modulator with glycine-site partial agonist properties and currently in a phase II clinical development program as an adjunctive therapy for major depressive disorder. Mice given Rapastinel Trifluoroacetate (1.0 mg/kg) prior to acute ketamine (30 mg/kg) show clear preference for novel compare to familiar objects (P<0.01). Rapastinel Trifluoroacetate produces an antidepressant like effect in the USVs test, as indexed by an increase in hedonic 50-kHz USVs [F(1,20)=12.4, P<0.05] and a decrease in aversive 20-kHz USVs [F(1,20)=6.8, P<0.05]. Rapastinel Trifluoroacetate also produces an anxiolytic effect in the open field, as indexed by increased center time [F(1,20)=19.2, P<0.05] without altering locomotor activity as measured by line crosses [F(1,20)=0.0, P>0.05].
1435786-04-1
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更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/01/25 | HY-16728B | 1435786-04-1 Rapastinel Trifluoroacetate | 1435786-04-1 | 1mg | 990元 |
2024/01/25 | HY-16728B | 1435786-04-1 Rapastinel Trifluoroacetate | 1435786-04-1 | 5mg | 3100元 |
1435786-04-1, 1435786-04-1 相关搜索:
- 化合物RAPASTINEL TRIFLUOROACETATE
- 1435786-04-1
- GLYX 13,inhibit,Rapastinel Trifluoroacetate,GLYX13,GLYX-13,Inhibitor,Rapastinel,Ionotropic glutamate receptors,iGluR
- Rapastinel Trifluoroacetate