MSOP
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- CAS号:
- 66515-29-5
- 英文名:
- MSOP
- 英文别名:
- MSOP;2-Methyl-O- phosphonoserine;Serine, 2-methyl-O-phosphono-;(RS)-α-Methylserine-O-phosphate;(R,S)-a-Methylserine-O-phosphate;(RS)-ALPHA-METHYLSERINE-O-PHOSPHATE
- 中文名:
- MSOP
- 中文别名:
- 化合物 T12118;2-甲基-O-磷酸丝氨酸
- CBNumber:
- CB2407711
- 分子式:
- C4H10NO6P
- 分子量:
- 199.1
- MOL File:
- 66515-29-5.mol
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MSOP化学性质
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沸点:
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454.0±55.0 °C(Predicted)
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密度:
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1.681±0.06 g/cm3(Predicted)
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储存条件:
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Store at RT
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溶解度:
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H2O: soluble3mg/mL, clear (warmed)
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形态:
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powder
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酸度系数(pKa):
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1.66±0.10(Predicted)
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颜色:
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white to beige
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水溶解性:
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Soluble to 100 mM in water
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MSOP性质、用途与生产工艺
MSOP 是第三组代谢性谷氨酸受体的选择性拮抗剂,其对 L-AP4 敏感突触前代谢性谷氨酸受体的 KD 值为 51 μM。
K
D
: 51 μM (L-AP4-sensitive presynaptic mGluR).
In the presence of 200 μM MSOP, a rightward parallel shift of the dose-response curve to L-AP4 is observed, with an apparent K
D
calculated as 51±6 μM (n=3). MSOP is shown to be selective for the L-APC sensitive presynaptic mGluR, the apparent K
D
for the interaction of MSOP with the (1S, 3S)-ACPD sensitive receptor calculated as greater than 700 μM (n=3).
It is found that TBOA-induced antinociceptive effects are significantly blocked by intrathecal co-administration of MSOP (second phase of formalin model: F
3,16
=30.96, P<0.001; CFA model: F
3,16
=30.77, P<0.001). As expected, intrathecal TBOA (10 μg) reduces the number of formalin-induced flinches and shakes by 47% of the value in the saline-treated group in the second phase (P<0.001) and blocked the CFA-induced decrease in ipsilateral paw withdrawal latency by 60% of the value in the saline-treated group (P=0.01). The number of formalin-induced flinches in the second phase in the group treated with MSOP and TBOA is increased by 56% (P=0.04) of the value in the TBOA-treated group. CFA-induced paw withdrawal latency in the group treated with MSOP and TBOA is decreased by 86% (P=0.03) of the value in the TBOA-treated group.
MSOP
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/01/25 | HY-101226 | MSOP | | 1 mg | 1909元 |
2024/01/25 | HY-101226 | MSOP MSOP | 66515-29-5 | 5mg | 4200元 |
MSOP
生产厂家
全球有 37家供应商
MSOP国内生产厂家
66515-29-5, MSOP 相关搜索:
- Glutamate receptor
- 66515-29-2
- 化合物 T12118
- 2-甲基-O-磷酸丝氨酸
- 66515-29-5
- 2-Methyl-O- phosphonoserine
- Serine, 2-methyl-O-phosphono-
- (RS)-α-Methylserine-O-phosphate
- (R,S)-a-Methylserine-O-phosphate
- (RS)-ALPHA-METHYLSERINE-O-PHOSPHATE
- MSOP