N-辛酰基-D-神经鞘氨醇
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- CAS号:
- 74713-59-0
- 英文名:
- C8 CERAMIDE
- 英文别名:
- C8 CERAMIDE;CERAMIDE C8;08:0 CERAMIDE;N-Octanoyl-D-erythr;N-OCTANOYLSPHINGOSINE;C8-D-ERYTHRO-CERAMIDE;C8 CERAMINE, D-ERYTHRO;N-Octanoyl-D-erythro-sp;C8 Ceramide (d18:1/8:0);N-OCTANOYL-D-SPHINGOSINE
- 中文名:
- N-辛酰基-D-神经鞘氨醇
- 中文别名:
- C-8神经酰胺;N-辛酰基鞘氨醇;N-辛酰神经鞘氨醇;N-辛酰基-D-神经鞘氨醇;N-辛酰基-D-赤型鞘氨醇;N-[(1S,2R,3E)-2-羟基-1-(羟甲基)-3-十七碳烯-1-基]-辛酰胺;N-[(1S,2R,3E)-2-羟基-1-(羟基甲基)-3-十七碳烯-1-基]-辛酰胺
- CBNumber:
- CB2432038
- 分子式:
- C26H51NO3
- 分子量:
- 425.69
- MOL File:
- 74713-59-0.mol
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N-辛酰基-D-神经鞘氨醇化学性质
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熔点:
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68-70°C
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沸点:
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541.37°C (rough estimate)
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密度:
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0.9974 (rough estimate)
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折射率:
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1.6000 (estimate)
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储存条件:
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−20°C
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溶解度:
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DMSO or ethanol: soluble
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形态:
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waxy solid
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颜色:
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White
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稳定性:
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Temperature Sensitive
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CAS 数据库:
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74713-59-0(CAS DataBase Reference)
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N-辛酰基-D-神经鞘氨醇性质、用途与生产工艺
C8-Ceramide (N-Octanoyl-D-erythro-sphingosine) 是一种细胞渗透性的内源性神经酰胺类似物。C8-Ceramide 具有具有抗增殖特性，能作为化疗试剂。C8-Ceramide 能刺激树突状细胞促进 T 细胞对病毒感染的反应。C8-Ceramide 在体外能轻微地诱导 PKC 活化。
C8-ceramide (3 μM; 48 hours) irreversibly reduces tumor-cell proliferation and induces morphological changes.
C8-ceramide can induce necrosis-like cell death, but does not induce caspase-dependent cleavage of PARP (biochemical marker of apoptosis) in human cervical tumor cells.
C8-ceramide may increase the endogenous ROS level (10-30 µM; 24 hours) by regulating the switch of SOD1 and SOD2, causing the anti-proliferation (10-50 µM; 24 hours), and consequently triggering the apoptosis (10-50 µM; 48 hours) of NSCLC H1299 cells.
Cell Viability Assay
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Cell Line:
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CALO cells, INBL cells, HeLa cells
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Concentration:
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3 μM
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Incubation Time:
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48 hours
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Result:
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Markedly reduced the tumor cell number.
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Cell Proliferation Assay
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Cell Line:
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H1299 cells
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Concentration:
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10 µM, 20 µM, 30 µM, 40 µM, 50 µM
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Incubation Time:
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24 hours
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Result:
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Decreased the rate of cellular proliferation in a dose-dependent manner, with an IC
50
of 22.9 µM.
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Cell Cycle Analysis
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Cell Line:
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H1299 cells
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Concentration:
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10 µM, 20 µM, 30 µM, 40 µM, 50 µM
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Incubation Time:
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24 hours
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Result:
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Caused the G1 arrest.
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Apoptosis Analysis
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Cell Line:
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H1299 cells
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Concentration:
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10 µM, 20 µM, 30 µM
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Incubation Time:
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24 hours, 48 hours
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Result:
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Increased the level of cleaved caspase-3.
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C8-ceramide (0.1 mg/kg; intranasal administration) induces more robust CD8
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and CD4
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T cell responses to viral infections in virus infected mice.
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Animal Model:
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C57BL/6 mice, with lymphocytic choriomeningitis virus infected
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Dosage:
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0.1 mg/kg
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Administration:
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Intranasal administration
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Result:
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Increased the CD8
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T cell response to influenza in the lungs.
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N-辛酰基-D-神经鞘氨醇
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-108391 | N-辛酰基-D-神经鞘氨醇
C8-Ceramide | 74713-59-0 | 5mg | 950元 |
| 2024/01/25 | HY-108391 | N-辛酰基-D-神经鞘氨醇
C8-Ceramide | | 10 mg | 1650元 |
74713-59-0, N-辛酰基-D-神经鞘氨醇 相关搜索:
- Protein Kinase Inhibitors and Activators
- Inhibitors
- Glycerols
- Fatty Acid Derivatives & Lipids
- Activators
- Mixed Fatty Acids
- 高端化学
- 小分子
- 生化试剂
- 脂类
- Sphingolipids
- N-acylsphingosines (ceramides)
- Lipids
- Ceramides
- BioChemical
- Biochemicals and Reagents
- C26H51NO3
- N-辛酰基鞘氨醇
- C-8神经酰胺
- N-[(1S,2R,3E)-2-羟基-1-(羟甲基)-3-十七碳烯-1-基]-辛酰胺
- N-辛酰基-D-赤型鞘氨醇
- N-[(1S,2R,3E)-2-羟基-1-(羟基甲基)-3-十七碳烯-1-基]-辛酰胺
- N-辛酰神经鞘氨醇
- N-辛酰基-D-神经鞘氨醇
- 74713-59-0
- Octanamide, N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-
- N-((2S,3R,E)-1,3-dihydroxyoctadec-4-en-2-yl)heptanamide
- N-OCTANOYL-D-ERYTHRO-SPHINGOSINE;C8 CERAMIDE (D18:1/8:0)
- C8 Ceramide (d18:1/8:0)
- N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-Octanamide
- D-erythro N-Octanoyl-D-erythro-sphingosine
- N-Octanoyl-D-erythro-sp
- [R-[R*,S*-(E)]]-N-[2-Hydroxy-1-(hydroxyMethyl)-3-heptadecenyl]octanaMide
- N-Octanoyl-D-erythro-sphingosine, synthetical, 99+%
- N-Octanoyl-D-erythro-sphingosineCeramide C8
- N-Octanoyl-D-erythro-sphingosine, synthetical
- N-OCTANOYL-D-ERYTHRO-SPHINGOSINE, 99+%, SYNTHETICAL
- CERAMIDE C8
- D-ERYTHRO-SPHINGOSINE, N-OCTANOYL-
- C8-D-ERYTHRO-CERAMIDE
- C8 CERAMINE, D-ERYTHRO
- C8 CERAMIDE
- 08:0 CERAMIDE
- Octanamide, N-[2-hydroxy-1-(hydroxymethyl)-3-heptadecenyl]-, [R-[R*,S*-(E)]]-
- N-Octanoyl-D-erythr
- N-Octanoyl-C18-sphingosine
- N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecenyl]Octanamide
- D-erythro-N-Octanoylsphingosine
- N-OCTANOYLSPHINGOSINE
- N-OCTANOYL-D-SPHINGOSINE
- N-OCTANOYL-D-ERYTHRO-SPHINGOSINE
- N-OCTANOYLSPHINGOSINE, D-ERYTHRO