氯非铵甲苯磺酸盐
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- CAS号:
- 92953-10-1
- 英文名:
- CLOFILIUM TOSYLATE
- 英文别名:
- CLOFILIUM TOSYLATE;4-CHLORO-N,N-DIETHYL-N-HEPTYLBENZENEBUTANAMINIUM TOSYLATE;4-chloro-n,n-diethyl-n-heptyl-benzenebutanaminiusaltwith4-methylbenzenes;Clofilium tosylate,Potassium Channel,Clofilium,inhibit,Apoptosis,Inhibitor,KcsA;N-(4-(4-CHLOROPHENYL)BUTYL)-N,N-DIETHYLHEPTAN-1-AMINIUM 4-METHYLBENZENESULFONATE
- 中文名:
- 氯非铵甲苯磺酸盐
- 中文别名:
- 氯非铵甲苯磺酸盐
- CBNumber:
- CB2435110
- 分子式:
- C28H44ClNO3S
- 分子量:
- 510.17
- MOL File:
- 92953-10-1.mol
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氯非铵甲苯磺酸盐化学性质
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储存条件:
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4°C, protect from light
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溶解度:
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H2O: soluble
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形态:
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solid
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颜色:
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white
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氯非铵甲苯磺酸盐性质、用途与生产工艺
Clofilium tosylate 是一种钾通道 (potassium channel) 阻滞剂，作用于人早幼粒细胞白血病 (HL-60) 细胞，激活 caspase-3 而诱导凋亡。具有抗心律失常作用。
HL-60 cells treated with Clofilium (0-20 μM; 24, 48, and 72 hours) lead to suppression of viability and proliferation in both time and concentration-dependent manners. Cell viability decreases significantly in HL-60 cells treated with 2.5 μM to 10 μM of Clofilium.
Clofilium (10 μM, 12 hours) induces the proteolytic cleavage of inactive procaspase-3, p34 into its active form, p17 and subsequent cleavage of its substrate PARP at 2 h after exposure to 10 mM Clofilium. However, there is no significant change in expression of Bcl-2 and Bax proteins.
Cell Viability Assay
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Cell Line:
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HL-60 cells
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Concentration:
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0-20 μM
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Incubation Time:
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24, 48, and 72 hours
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Result:
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Inhibited HL-60 cells with IC
50
s of 6.3 μM for 24 hours, 3.4 μM for 48 hours, 2.4 μM for 72 hours, respectively.
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Western Blot Analysis
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Cell Line:
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HL-60 cells
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Concentration:
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10 μM
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Incubation Time:
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12 hours
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Result:
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Induced proteolytic cleavage of caspase-3 and subsequent cleavage of its substrate, PARP, while Bcl-2 and Bax proteins were unaltered.
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氯非铵甲苯磺酸盐
上下游产品信息
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/01/25 | HY-33350 | Clofilium tosylate | | 1 mg | 308元 |
| 2024/01/25 | HY-33350 | Clofilium tosylate | | 5 mg | 770元 |
92953-10-1, 氯非铵甲苯磺酸盐 相关搜索:
- C21H37ClNC7H7O3S
- 氯非铵甲苯磺酸盐
- 92953-10-1
- Clofilium tosylate,Potassium Channel,Clofilium,inhibit,Apoptosis,Inhibitor,KcsA
- N-(4-(4-CHLOROPHENYL)BUTYL)-N,N-DIETHYLHEPTAN-1-AMINIUM 4-METHYLBENZENESULFONATE
- 4-CHLORO-N,N-DIETHYL-N-HEPTYLBENZENEBUTANAMINIUM TOSYLATE
- 4-chloro-n,n-diethyl-n-heptyl-benzenebutanaminiusaltwith4-methylbenzenes
- CLOFILIUM TOSYLATE