ChemicalBook
English   Japanese   Germany   Korea

GSK205

GSK205, 1263068-83-2, 结构式
GSK205
CAS号:
1263068-83-2
英文名:
GSK205 HBr
英文别名:
GSK205;GSK205 HBr;N-(4-(2-(Benzyl(methyl)amino)ethyl)phenyl)-5-(pyridin-3-yl)thiazol-2-amine hydrobromide
中文名:
GSK205
中文别名:
化合物 T11480;N-(4-(2-(苄基(甲基)氨基)乙基)苯基)-5-(吡啶-3-基)噻唑-2-胺氢溴酸盐
CBNumber:
CB25494080
分子式:
C24H25BrN4S
分子量:
481.46
MOL File:
1263068-83-2.mol

GSK205化学性质

储存条件:
Store at -20°C
溶解度:
DMSO: 250 mg/mL (519.26 mM)
安全信息

GSK205性质、用途与生产工艺

生物活性

GSK205 是一种高效的,选择性的 TRPV4 拮抗剂,IC50 值为 4.19 μM,可抑制 TRPV4 介导的 Ca2+ 内流。

靶点

IC50: 4.19  μM (TRPV4)

体外研究

GSK205 (100 μM) potently antagonizes TRPV4 in 3T3-F442A adipocytes, as it effectively blocks the calcium influx caused by TRPV4 agonist.
GSK205 (5 μM; 4 days; T3-F442A adipocytes) treatment results in increases expression of thermogenic genes (Mcp1, Mip1α, Mcp3, Rantes and Vcam, et al.) and is also accompanied by a decrease in the proinflammatory gene program. This shift resembles the gene expression changes seen in TRPV4-deficient adipocytes.

RT-PCR

Cell Line: T3-F442A adipocytes
Concentration: 5 μM
Incubation Time: 4 days
Result: Resulted in increased expression of thermogenic genes and is also accompanied by a decrease in the proinflammatory gene program.

体内研究

GSK205 (10 mg/kg; intraperitoneal injection; twice daily; for 7 days; for 4 weeks; male C57BL/6J mice) treatment shows significantly increases expression of thermogenic genes such as Ucp1, Pgc1a, Cidea and Cox8b. GSK205 treatment causes a reduced expression of the proinflammatory chemokines, macrophage marker and Tnfa in the EPI fat. GSK205 treatment significantly improves glucose tolerance in diet-induced obese (DIO) mice. There are no apparent sign of sickness or weight loss.
GSK205 has a relatively short half-life of 2 hours in the plasma and adipose tissues.

Animal Model: Male C57BL/6J mice with high-fat diet
Dosage: 10 mg/kg
Administration: Intraperitoneal injection; twice daily; for 7 days
Result: Caused a reduced expression of the proinflammatory chemokines, macrophage marker and Tnfa in the EPI fat. Significantly improved glucose tolerance in diet-induced obese (DIO) mice.

GSK205 上下游产品信息

上游原料

下游产品

GSK205 试剂级价格

更新日期产品编号产品名称CAS编号包装价格
2024/01/25HY-120691AGSK2051 mg863元
2024/01/25HY-120691AGSK205
GSK205
1263068-83-25mg1900元

GSK205 生产厂家

全球有 17家供应商   GSK205国内生产厂家
供应商联系电话电子邮件国家产品数优势度
上海睿升化工科技有限公司 15026594951 rs@raise-chem.com 中国 3094 55
上海芮晖化工科技有限公司 21-31433387 15618786686 sales@rechemscience.com 中国 2972 58
范德(北京)生物科技有限责任公司 15911056312 liming@bio-fount.com 中国 9730 58
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 marketing@targetmol.com 美国 19892 58
ChemeGen 中国 18818260767 sales@chemegen.com 中国 11289 58
上海弘渠生物医药科技有限公司 88888888888 hongquchem@qq.com 中国 5132 58
上海传芊化工科技中心 15869524721 3525679403@qq.com 中国 4301 58
天津普西唐生物医药科技有限公司 010-60605840 15801484223 psaitong@jm-bio.com 中国 29834 58
上海毕得医药科技股份有限公司 400-1647117 15221909166 product02@bidepharm.com 中国 61788 58
上海瀚思化工有限公司 17717618050 zllg@gh-reagent.com 中国 10424 58
TargetMol中国(陶术生物) 4008200310 marketing@tsbiochem.com 中国 24131 58
北京伊诺凯科技有限公司 15652467323 15652467323 sales@inno-chem.com.cn 中国 8293 58
沈阳中申泽康生物医学技术研究有限公司 024-024-88590548 18341751992 757984502@qq.com 中国 888 58
北京索莱宝科技有限公司 010-50973185 17801761073 Gsiyu@solarbio.com 中国 49971 58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd +86-18341751992 +86-15382112998 757984502@qq.com 中国 892 58
 

1263068-83-2, GSK205 相关搜索:

  • 化合物 T11480
  • N-(4-(2-(苄基(甲基)氨基)乙基)苯基)-5-(吡啶-3-基)噻唑-2-胺氢溴酸盐
  • 1263068-83-2
  • N-(4-(2-(Benzyl(methyl)amino)ethyl)phenyl)-5-(pyridin-3-yl)thiazol-2-amine hydrobromide
  • GSK205
  • GSK205 HBr
Copyright 2016 © ChemicalBook. All rights reserved