西托溴铵
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- CAS号:
- 51598-60-8
- 英文名:
- Cimetropium bromide
- 英文别名:
- da3177;Cimetropium;DA-3177:Alginor;Cimetropiumbromid;Cimetronin bromide;CIMETROPIUM BROMIDE;N-Cyclopropvlmethylscopolamine bromide;(7(S)-(1alpha,2beta,4beta,5alpha,7beta))-9-(Cyclopropylmethyl)-7-(3-hydroxy-1-oxo-2-phenylpropoxy)-9-methyl-3-oxa-9-azoniatricyclo(3.3.1.0(sup 2,4))nonane bromide
- 中文名:
- 西托溴铵
- 中文别名:
- 西托溴铵;化合物 T14966;溴化N-(环丙基甲基)东莨菪碱
- CBNumber:
- CB2668860
- 分子式:
- C21H28BrNO4
- 分子量:
- 438.36
- MOL File:
- 51598-60-8.mol
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西托溴铵化学性质
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熔点:
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174°
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比旋光度:
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D20 -18.3° (c = 3)
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储存条件:
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Hygroscopic, -20°C Freezer, Under inert atmosphere
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溶解度:
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DMSO (Slightly), Methanol (Slightly), Water (Slightly)
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形态:
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Solid
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颜色:
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White
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西托溴铵性质、用途与生产工艺
Cimetropium Bromide (DA-3177) 是一种毒蕈碱受体拮抗剂,用于长期研究肠易激综合征。
Cimetropium Bromide behaves as a competitive antagonist of muscarinic-mediated contractions in isolated colonic preparations from both species, with affinity values (pA2) ranging between 7.41 and 7.82. Cimetropium has potent antimuscarinic effect in inhibition of contraction of longitudinal muscle preparations. In the superfusion experiments of the preparation which has been preloaded with labelled choline, Cimetropium decreases the labelled ACh release induced by electrical field stimulation under the muscarinic autoinhibition blocked-condition.
When administered intravenously to conscious dogs provided with a colonic Thiry fistula, Cimetropium is a potent inhibitor of large bowel motility evoked by both exogenous and endogenous stimuli. Cimetropium Bromide (10-100 μg/kg) counteracts colonic motor response to neostigmine administration with an ID
50
of 27.9 μg/kg; both tonic and phasic components of contractile response are affected. In a comparable range of doses (3-100μg/kg), the drug inhibits motor activity elicited by intraluminal distension.
化学性质
从乙腈结晶,熔点174℃。[α]
D20-18.3°(C=3)。
用途
能阻断内脏平滑肌的毒蕈碱型受体,因而有抗毒草碱的作用,还有解除平滑肌的痉挛。用于胆石绞痛、肾绞痛、胃肠道痉挛痛、胆道和尿路痉挛痛、痛经、分娩痛等。
生产方法
由化合物(Ⅰ)和环丙基溴甲烷,在乙腈中回流15~99h,得到西托溴铵。
西托溴铵
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/01/25 | HY-U00106 | 西托溴铵 Cimetropium Bromide | 51598-60-8 | 1 mg | 1000元 |
2024/01/25 | HY-U00106 | 西托溴铵 Cimetropium Bromide | 51598-60-8 | 10mM * 1mLin Water | 1929元 |
西托溴铵
生产厂家
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西托溴铵国内生产厂家
51598-60-8, 西托溴铵 相关搜索:
- 药物
- 麻醉用药
- 肌肉松弛药
- C21H28NO4Br
- 化合物 T14966
- 溴化N-(环丙基甲基)东莨菪碱
- 西托溴铵
- 51598-60-8
- (7(S)-(1alpha,2beta,4beta,5alpha,7beta))-9-(Cyclopropylmethyl)-7-(3-hydroxy-1-oxo-2-phenylpropoxy)-9-methyl-3-oxa-9-azoniatricyclo(3.3.1.0(sup 2,4))nonane bromide
- N-Cyclopropvlmethylscopolamine bromide
- DA-3177:Alginor
- Cimetropiumbromid
- Cimetropium
- Cimetronin bromide
- CIMETROPIUM BROMIDE
- da3177