2-胍基琥珀酸
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- CAS号:
- 6133-30-8
- 英文名:
- GUANIDINOSUCCINIC ACID
- 英文别名:
- NSC49078;NSC 49078;NSC-49078;guanidinosuccic acid;n-amidino-asparticaci;GUANIDINOSUCCINIC ACID;N-amidinoaspartic acid;N-amidino-L-asparticaci;2-Guanidinosuccinic acid;L-N-Amidinoaspartic acid
- 中文名:
- 2-胍基琥珀酸
- 中文别名:
- 胍基琥珀酸;L-胍基丁二酸;2-胍基琥珀酸;(S)-2-胍基丁二酸;(S)-2-胍基琥珀酸
- CBNumber:
- CB2710712
- 分子式:
- C5H9N3O4
- 分子量:
- 175.14
- MOL File:
- 6133-30-8.mol
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2-胍基琥珀酸化学性质
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沸点:
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344.5±52.0 °C(Predicted)
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密度:
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1.74±0.1 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMSO: 1 mg/ml; PBS (pH 7.2): 5 mg/ml
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形态:
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A solid
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酸度系数(pKa):
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3.22±0.23(Predicted)
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2-胍基琥珀酸性质、用途与生产工艺
Guanidinosuccinic acid 是从血清和尿液中分离出的含氮代谢物，在尿毒症患者的尿液和血清中升高。
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Human Endogenous Metabolite
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Guanidinosuccinic acid, a constituent of normal urine, is elevated in the urine and serum of azotemic patients. Guanidinosuccinic acid (GSA), a guanidino compound found to be greatly increased in uremia, is administered by intraperitoneal (i.p.) injection to adult albino mice and to young mice 7, 14 and 21 days old. Epileptogenic and toxic properties are assessed and Guanidinosuccinic acid brain levels following i.p. injection ae determined. In adult mice, Guanidinosuccinic acid induces long-lasting generalized clonic and clonic-tonic convulsions in a dose-dependent manner with a CD
50
(and 95% confidence interval) of 363 (287-458) mg/kg (n=35), and an LD
50
of 579 (445-756) mg/kg. The CD
50
of Guanidinosuccinic acid corresponded with a brain concentration of 56 nmol/g tissue. Electrocorticographic recording in five adult mice revealed epileptiform discharges (spikes, spike-waves, and polyspike-waves) which appeared concomitant with the convulsions, When young mice are i.p. injected with a (for adults) subconvulsive dose of Guanidinosuccinic acid (250 mg/kg), an age-dependent decrease is noted in Guanidinosuccinic acid-induced convulsions and in the resulting brain concentration.
2-胍基琥珀酸
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-113373 | Guanidinosuccinic acid | | 5 mg | 312元 |
| 2024/01/25 | HY-113373 | 2-胍基琥珀酸
Guanidinosuccinic acid | 6133-30-8 | 10mg | 500元 |
6133-30-8, 2-胍基琥珀酸 相关搜索:
- amino acids
- 药靶配体
- 有机化学品
- Modified Amino Acids
- Biochemicals and Reagents
- BioChemical
- Amino Acids and Peptides
- A - H
- C5H9N3O4
- C5H9O4N3
- (S)-2-胍基丁二酸
- L-胍基丁二酸
- 胍基琥珀酸
- (S)-2-胍基琥珀酸
- 2-胍基琥珀酸
- 6133-30-8
- NSC-49078
- NSC49078
- NSC 49078
- L-N-Amidinoaspartic acid
- N-amidino-L-asparticaci
- Inhibitor,Endogenous Metabolite,Guanidinosuccinic acid,inhibit
- N-amidinoaspartic acid
- N-carbamimidoyl-L-aspartic acid
- (S)-2-Guanidinosuccinic acid
- n-amidino-asparticaci
- n-(aminoiminomethyl)-l-asparticaci
- alpha-guanidinosuccinicacid
- N-AMIDINO-L-ASPARTIC ACID
- GUANIDINOSUCCINIC ACID
- (S)-GUANIDINOSUCCINIC ACID dihydrobromide
- guanidinosuccic acid
- (S)-GUANIDINOSUCCINIC ACID
- 2-Guanidinosuccinic acid
- L-ASPARTICACID,N-(AMINOIMINOMETHYL)-
- (2S)-2-(diaminomethylideneamino)butanedioic acid