3-甲基亚磺酰丙基异硫氰酸酯
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- CAS号:
- 505-44-2
- 英文名:
- IBERIN
- 英文别名:
- IBERIN;lberin;NSC 321801;IBERIN(RG);3-methylsulphinylpropylisothiocyanate;3-(Methylsulfinyl)propyl isothiocyanate;Methyl(3-isothiocyanatopropyl) sulfoxide;3-methylsulfinylpropylimino(thioxo)methane;1-isothiocyanato-3-(methylsulfinyl)propane;1-ISOTHIOCYANATO-3-(METHYLSULPHINYL)-PROPANE
- 中文名:
- 3-甲基亚磺酰丙基异硫氰酸酯
- 中文别名:
- 化合物 T15544;3-甲基亚磺酰丙基异硫氰酸酯
- CBNumber:
- CB2779788
- 分子式:
- C5H9NOS2
- 分子量:
- 163.26
- MOL File:
- 505-44-2.mol
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3-甲基亚磺酰丙基异硫氰酸酯化学性质
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沸点:
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240.37°C (rough estimate)
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密度:
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1.142 (estimate)
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折射率:
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1.5237 (estimate)
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储存条件:
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Hygroscopic, Refrigerator, under inert atmosphere
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溶解度:
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Chloroform (Slightly), Methanol (Slightly)
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形态:
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Oil
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颜色:
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Colourless
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稳定性:
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Moisture Sensitive
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3-甲基亚磺酰丙基异硫氰酸酯性质、用途与生产工艺
Iberin (NSC 321801) 是萝卜硫素的亚砜类似物,是天然存在的异硫氰酸酯家族的成员。抑制 HL60 细胞的 IC50 值为 2.3 μM。Iberin 诱导凋亡 (apoptosis)。
Human Endogenous Metabolite
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Iberin inhibits the growth of neuroblastoma cells in a dose- and time-dependent manner. The iberin-induced cell cycle arrest in neuroblastoma cells is associated with inhibition of expression of cyclin-dependent kinase Cdk2, Cdk4, and Cdk6 proteins. There is an increase in apoptotic cell death in iberin treated cells as compared with control cells. The iberin-induced apoptosis is found to be associated with activation of caspase-9, caspase-3, and PARP. Iberin inhibits growth of human glioblastoma cells in cell proliferation assays, enhances cytotoxicity, and induces apoptosis by activation of caspase-3 and caspase-9.
Iberin is tested in an
in vivo
foreign-body infection mouse model, and the results show no significantly difference in bacterial clearance between treated and nontreated miced. Iberin increases tissue levels of the phase II detoxification enzymes quinone reductase and glutathione S-transferase in a variety of rat tissues.
3-甲基亚磺酰丙基异硫氰酸酯
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下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/01/25 | HY-101413 | 3-甲基亚磺酰丙基异硫氰酸酯 Iberin | 505-44-2 | 1mg(61.25mM * 100μL in Ethanol) | 500元 |
2024/01/25 | HY-101413 | Iberin | | 5 mg (61.25 mM * 500 μL in Ethanol) | 1100元 |
505-44-2, 3-甲基亚磺酰丙基异硫氰酸酯 相关搜索:
- 抑制剂
- C5H9NOS2
- 化合物 T15544
- 3-甲基亚磺酰丙基异硫氰酸酯
- 505-44-2
- Propane, 1-isothiocyanato-3-(methylsulfinyl)-
- NSC 321801
- lberin
- IBERIN(RG)
- 3-methylsulfinylpropylimino(thioxo)methane
- Methyl(3-isothiocyanatopropyl) sulfoxide
- 3-(Methylsulfinyl)propyl isothiocyanate
- 1-ISOTHIOCYANATO-3-(METHYLSULPHINYL)-PROPANE
- isothiocyanicacid,3-(methylsulfinyl)propylester
- 3-methylsulphinylpropylisothiocyanate
- 1-isothiocyanato-3-(methylsulfinyl)propane
- IBERIN