匹伐加宾
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- CAS号:
- 69542-93-4
- 英文名:
- Pivagabine
- 英文别名:
- Tonerg;CXB 722;Pivagabine;PG 2 (pharmaceutical);4-PivalaMidobutanoic acid;4-(Pivaloylamino)butanoic acid;N-trimethylacetyl-4-aminobutyric acid;4-(2,2-Dimethylpropionamido)butanoic acid;4-[(2,2-dimethylpropionyl)amino]butyric acid;Butanoic acid,4-[(2,2-diMethyl-1-oxopropyl)aMino]-
- 中文名:
- 匹伐加宾
- 中文别名:
- 匹伐加宾;4-新戊酰氨基丁酸
- CBNumber:
- CB2928582
- 分子式:
- C9H17NO3
- 分子量:
- 187.24
- MOL File:
- 69542-93-4.mol
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匹伐加宾化学性质
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沸点:
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397.0±25.0 °C(Predicted)
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密度:
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1.053±0.06 g/cm3(Predicted)
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储存条件:
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Sealed in dry,Room Temperature
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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4.66±0.10(Predicted)
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匹伐加宾性质、用途与生产工艺
Pivagabine (CXB 722) 是具有神经调节活性的疏水性4-氨基丁酸衍生物。Pivagabine 能穿透大鼠的血脑屏障。Pivagabine 拮抗足部休克对大鼠脑内 GABAA 受体功能和促肾上腺皮质激素释放因子 (CRF) 浓度的影响。
Pivagabine (CXB 722) (200 mg/kg; i.p.; twice a day for 4 days and 1 hour before killing on the 5th day) prevents the effects of foot-shock stress on CRF concentration in both brain regions.
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Animal Model:
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Adult male Sprague-Dawley CD rats (200-250 g)
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Dosage:
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200 mg/kg
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Administration:
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i.p.; twice a day for 4 days and 1 hour before killing on the 5th day
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Result:
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Prevented the effects of foot-shock stress on CRF concentration in both brain regions. Reduced by 52% the CRF concentration in the hypothalamus but had no effect on that in the cerebral cortex.
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匹伐加宾
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-108295 | Pivagabine | | 1 mg | 600元 |
| 2024/01/25 | HY-108295 | 匹伐加宾
Pivagabine | 69542-93-4 | 10mM * 1mLin DMSO | 869元 |
匹伐加宾
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匹伐加宾国内生产厂家
69542-93-4, 匹伐加宾 相关搜索:
- 4-新戊酰氨基丁酸
- 匹伐加宾
- 69542-93-4
- Pivagabine,blood-brain,γ-Aminobutyric acid Receptor,psychoactive,CXB722,derivative,Inhibitor,inhibit,foot,factor,barrier,CXB 722,shock,Gamma-aminobutyric acid Receptor,GABA Receptor,neuromodulatory,corticotropin-releasing
- 4-(2,2-Dimethylpropionamido)butanoic acid
- N-trimethylacetyl-4-aminobutyric acid
- Pivagabine
- Butanoic acid,4-[(2,2-diMethyl-1-oxopropyl)aMino]-
- Tonerg
- PG 2 (pharmaceutical)
- CXB 722
- 4-PivalaMidobutanoic acid
- 4-(Pivaloylamino)butanoic acid
- 4-[(2,2-dimethylpropionyl)amino]butyric acid