BETA- AMYLOID (1-16)
|
|
|
- CAS号:
- 131580-10-4
- 英文名:
- H-ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-VAL-HIS-HIS-GLN-LYS-OH
- 英文别名:
- β-Amyloid 1-16;DAEFRHDSGYEVHHQK;BETA-AMYLOID (1-16);Bate-Amyloid (1-16);β-Amyloid (1-16), human;AMyloid b-Protein (1-16);Amyloid β-Protein (1-16);AMYLOID BETA-PROTEIN (1-16);[Gln11] -β- Amyloid (1 - 16);[Gln11] -Bate- Amyloid (1 - 16)
- 中文名:
- BETA- AMYLOID (1-16)
- 中文别名:
- Β-淀粉样蛋白 AMYLOID Β-PROTEIN (1-16);Β-AMYLOID (1-16), HUMAN;AMYLOID BETA-PROTEIN (1-16) TRIFLUOROACETATE SALT
- CBNumber:
- CB3110326
- 分子式:
- C84H119N27O28
- 分子量:
- 1955.01
- MOL File:
- 131580-10-4.mol
|
|
|
BETA- AMYLOID (1-16)化学性质
-
密度:
-
1.57±0.1 g/cm3(Predicted)
-
|
-
储存条件:
-
-15°C
-
|
-
溶解度:
-
Soluble in DMSO
-
|
-
形态:
-
Solid
-
|
-
水溶解性:
-
Soluble in water or aqueous buffer
-
|
-
序列:
-
H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-OH
-
|
BETA- AMYLOID (1-16)性质、用途与生产工艺
β-Amyloid (1-16) 是可参与金属结合的β-淀粉样蛋白片段。 β-淀粉样蛋白是在阿尔茨海默病患者的脑中形成淀粉样斑块的肽。
β-amyloid (1-16) fragment is considered as valid models to examine the contribution of the key histidine residues (His , His in mouse and His , His , His in human fragments) to the Ab–Cu
2+
interaction. Oxidation targets for β-Amyloid (1-16) are the histidine residues coordinated to the metal ions. Copper is bound to Aβ in senile plaque of Alzheimer’s disease with β-Amyloid (1-16) taking part in the coordination of the Cu
2+
ions. Cu
2+
and Zn
2+
are linked with the neurotoxicity of -Amyloid and free radical damage. β-amyloid (1-16) is the minimal amino acidic sequence display a Cu coordination mode which involves three Histidines (His6, His13 and His14). β-amyloid (1-16) is supposed to be involved in metal binding. Human β-amyloid interacts with zinc ions through its metal-binding domain 1-16. The C-tails of the two polypeptide chains of the rat Aβ(1-16) dimer are oriented in opposite directions to each other, which hinders the assembly of rat Aβ dimers into oligomeric aggregates. Thus, the differences in the structure of zinc-binding sites of human and rat β-Amyloid (1-16), their ability to form regular cross-monomer bonds, and the orientation of their hydrophobic C-tails could be responsible for the resistance of rats to Alzheimer's disease.
参考质量标准
外观:白色粉末
纯度(HPLC) ≥98.0%
醋酸根含量5.0%～12.0%
水分含量≤8.0%
肽含量≥80.0%
BETA- AMYLOID (1-16)
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-P1466 | BETA- AMYLOID (1-16)
β-Amyloid (1-16) | 131580-10-4 | 1mg | 1100元 |
| 2024/01/25 | HY-P1466 | BETA- AMYLOID (1-16)
β-Amyloid (1-16) | 131580-10-4 | 5mg | 3900元 |
BETA- AMYLOID (1-16)
生产厂家
131580-10-4, BETA- AMYLOID (1-16) 相关搜索:
- peptide
- 目录肽
- 目录多肽
- 多肽
- C84H119N27O28
- 31580-10-4
- Β-淀粉样蛋白 AMYLOID Β-PROTEIN (1-16)
- Β-AMYLOID (1-16), HUMAN;AMYLOID BETA-PROTEIN (1-16) TRIFLUOROACETATE SALT
- 131580-10-4
- [Gln11] -Bate- Amyloid (1 - 16)
- Bate-Amyloid (1-16)
- Amyloid β-Protein (1-16) trifluoroacetate salt
- β-Amyloid (1-16), human
- Amyloid β-Protein (1-16)
- H-ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-VAL-HIS-HIS-GLN-LYS-OH USP/EP/BP
- Amyloidβ-Protein(1-16)/β-Amyloid(1-16),human
- [Gln11] -β- Amyloid (1 - 16)
- β-Amyloid 1-16
- L-Lysine, L-α-aspartyl-L-alanyl-L-α-glutamyl-L-phenylalanyl-L-arginyl-L-histidyl-L-α-aspartyl-L-serylglycyl-L-tyrosyl-L-α-glutamyl-L-valyl-L-histidyl-L-histidyl-L-glutaminyl-
- Amyloid beta-Protein (1-16) trifluoroacetate salt
- AMYLOID BETA-PROTEIN (1-16)
- AMyloid b-Protein (1-16)
- H-ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-VAL-HIS-HIS-GLN-LYS-OH
- DAEFRHDSGYEVHHQK
- BETA-AMYLOID (1-16)