朱砂精酸
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- CAS号:
- 606-59-7
- 英文名:
- cinnabarinic acid
- 英文别名:
- Cinnabaric Acid;cinnabarinic acid;*Halothane Impurity 5 (Halothane EP Impurity E);2-Amino-3-oxo-3H-phenoxazine-1,9-dicarboxylic acid;3H-Phenoxazine-1,9-dicarboxylic acid, 2-amino-3-oxo-
- 中文名:
- 朱砂精酸
- 中文别名:
- 朱砂精酸;化合物 T22669
- CBNumber:
- CB31312499
- 分子式:
- C14H8N2O6
- 分子量:
- 300.22
- MOL File:
- 606-59-7.mol
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朱砂精酸化学性质
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熔点:
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>300°C
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密度:
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1.79
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储存条件:
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2-8°C
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溶解度:
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DMSO: ≥4mg/mL
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形态:
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powder
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颜色:
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red to very dark red
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稳定性:
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Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 1 month.
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朱砂精酸性质、用途与生产工艺
Cinnabarinic acid 是 mGlu4 特异性的别构激动剂，可以与 mGlu4 的谷氨酸结合袋残基相互作用，在其他 mGlu 受体亚型上没有活性。Cinnabarinic acid 是色氨酸 kynurenine 途径的内源性代谢物。Cinnabarinic acid 可以诱导细胞凋亡 (apoptosis)。
Cinnabarinic acid (0-100 μM) does not activate mGlu1, mGlu2, mGlu5, mGlu6, mGlu7, and mGlu8 receptors as shown by measurements of [
3
H]InsP formation. In contrast, cinnabarinic acid acts as a partial agonist of mGlu4 receptors by increasing [
3
H]InsP formation by approximately 35% at 100 μM, which is 5-fold less efficacious than ACPT-I in activating mGlu4 receptors in HEK293 cells transiently transfected with rat mGlu1, -2, -4, -5, -6, -7, or -8 receptors.
Cinnabarinic acid (0-100 μM) reduces cAMP formation in a concentration-dependent manner with an excellent potency and efficacy. At 30 μM, cinnabarinic acid is effective at 30 μM, and substantially inhibits cAMP formation in cultured cerebellar granule cells.
朱砂精酸
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-W011417 | 朱砂精酸
Cinnabarinic acid | 606-59-7 | 5mg | 1700元 |
| 2024/01/25 | HY-W011417 | 朱砂精酸
Cinnabarinic acid | 606-59-7 | 10mg | 2720元 |
朱砂精酸
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朱砂精酸国内生产厂家
606-59-7, 朱砂精酸 相关搜索:
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Heterocycles
- Amines
- 对照品
- 化合物 T22669
- 朱砂精酸
- 606-59-7
- *Halothane Impurity 5 (Halothane EP Impurity E)
- 3H-Phenoxazine-1,9-dicarboxylic acid, 2-amino-3-oxo-
- Cinnabaric Acid
- 2-Amino-3-oxo-3H-phenoxazine-1,9-dicarboxylic acid
- cinnabarinic acid