新植二烯
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- CAS号:
- 504-96-1
- 英文名:
- 7,11,15-trimethyl-3-methylidene-hexadec-1-ene
- 英文别名:
- Neophytadiene;Neophytadiene (80%);Hsdb 4321;Imidaprilat Impurity 1-d3;7,11,15-Trimethyl-3-methylene-1-hexadecene;3-Methylene-7,11,15-trimethylhexadec-1-ene;2-(4,8,12-Trimethyltridecyl)buta-1,3-diene;2-(4,8,12-Trimethyltridecyl)-1,3-butadiene;1-Hexadecene, 7,11,15-trimethyl-3-methylene-;1,3-Butadiene, 2-(4,8,12-trimethyltridecyl)-
- 中文名:
- 新植二烯
- 中文别名:
- 新植二烯;NEOPHYTADIENE (80%)
- CBNumber:
- CB31456498
- 分子式:
- C20H38
- 分子量:
- 278.52
- MOL File:
- 504-96-1.mol
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新植二烯化学性质
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沸点:
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144-146 °C(Press: 3.5 Torr)
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密度:
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0.8168 g/cm3
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储存条件:
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-20°C Freezer
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溶解度:
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Benzene (Slightly), Chloroform (Soluble), Ethyl Acetate (Slightly)
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形态:
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Oil
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颜色:
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Colourless
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稳定性:
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Light Sensitive, Temperature Sensitive
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LogP:
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9.522 (est)
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EPA化学物质信息:
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1-Hexadecene, 7,11,15-trimethyl-3-methylene- (504-96-1)
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新植二烯性质、用途与生产工艺
Neophytadiene 是一种二萜，能从 Turbinaria ornate 中提取到，具有抗炎、抗氧化和心脏保护作用。
Neophytadiene has cytotoxic on RAW 264.7 cells with an IC
50
of 50 μM.
Neophytadiene (50-100 μM; 30 min) successfully inhibits the NO production level and downregulated inducible nitric oxide synthase (iNOS) production in LPS (1 μg/mL)-induced RAW264.7 cells.
Neophytadiene (25-100 μM; 22 hours) significantly inhibits the NO production and inflammatory cytokines TNF-α, IL-6 and IL-10 and IL-10 in LPS (1 μg/mL)-induced RAW264.7 cells.
Neophytadiene (50 mg/kg; p.o.) shows dose-dependent reduction in the alanine aminotransferase (ALT) level.
Neophytadiene (25-50 mg/kg; p.o.) significantly reduces LPS (10 mg/kg)-increased IL6 and 1L10 levels and in heart tissue.
Neophytadiene (25-50 mg/kg; p.o.) significantly reduces LPS (10 mg/kg)-increased PGE2mRNA expression in heart tissue.
Neophytadiene significantly inhibits LPS (10 mg/kg)-induced NO production and inflammatory cytokines TNF-α, IL-6 and IL-10 and IL-10 in vivo.
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Animal Model:
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Adult male Sprague Dawley rats (6-8 weeks)
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Dosage:
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12 mg/kg, 25 mg/kg, 50 mg/kg
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Administration:
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Oral administration, daily, for 7 days
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Result:
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Decreased haemoglobin (HGB) level, ALT level, and heart tissue TNF-α, IL1β, NF-κB, iNOS, PI3k/AktandMAPK in LPS (10 mg/kg)-treat rats.
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新植二烯
上下游产品信息
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新植二烯
生产厂家
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新植二烯国内生产厂家
504-96-1, 新植二烯 相关搜索:
- Inhibitors
- Aliphatics
- All Aliphatics
- 生化试剂
- 标准品
- 中药对照品
- NEOPHYTADIENE (80%)
- 新植二烯
- 504-96-1
- Imidaprilat Impurity 1-d3
- Neophytadiene (80%)
- Neophytadiene
- Hsdb 4321
- 1-Hexadecene, 7,11,15-trimethyl-3-methylene-
- 1,3-Butadiene, 2-(4,8,12-trimethyltridecyl)-
- 7,11,15-Trimethyl-3-methylene-1-hexadecene
- 3-Methylene-7,11,15-trimethylhexadec-1-ene
- 2-(4,8,12-Trimethyltridecyl)buta-1,3-diene
- 2-(4,8,12-Trimethyltridecyl)-1,3-butadiene
- 7,11,15-trimethyl-3-methylidene-hexadec-1-ene