盐酸奈替康唑
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- CAS号:
- 130773-02-3
- 英文名:
- Neticonazole Hydrochloride
- 英文别名:
- SS-717;Atolant;Neticonazole hydrochloride;1-[2-methylsulfanyl-1-(2-pentoxyphenyl)ethenyl]imidazole hydrochloride;1-[(E)-2-methylsulfanyl-1-(2-pentoxyphenyl)ethenyl]imidazole,hydrochloride;(E)-1-(2-(Methylthio)-1-(2-(pentyloxy)phenyl)vinyl)-1H-imidazole hydrochloride;long-acting,colorectal,Neticonazole,antifungal,Neticonazole Hydrochloride,Imidazole,anti-cancer,nSMase2,Fungal,secretion,Inhibitor,p-ERK,anti-infection,inhibit,exosome
- 中文名:
- 盐酸奈替康唑
- 中文别名:
- 盐酸萘康唑;盐酸奈康唑;盐酸奈替康唑;(E)-1-(2-(甲硫基)-1-(2-(戊氧基)苯基)乙烯基)-1H-咪唑盐酸盐
- CBNumber:
- CB31480006
- 分子式:
- C17H23ClN2OS
- 分子量:
- 338.9
- MOL File:
- 130773-02-3.mol
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盐酸奈替康唑化学性质
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熔点:
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145-147°
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 250 mg/mL (737.68 mM)
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盐酸奈替康唑性质、用途与生产工艺
Neticonazole是咪唑类抗真菌剂,用于治疗皮肤真菌感染。
Neticonazole (10 µM; 48 hours; C4-2B cells) treatment decreases the levels of both Alix and Rab27a, and significantly decreases nSMase2 levels. Neticonazole causes a significant inhibition in p-ERK levels.
Neticonazole (0-10 µM) exhibits a potent and dose-dependent inhibition of exosome release from C4-2B cells.
Neticonazole hydrochloride is also an orally active exosome biogenesis and secretion inhibitor.
Western Blot Analysis
Cell Line:
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C4-2B cells
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Concentration:
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10 µM
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Incubation Time:
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48 hours
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Result:
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Decreased the levels of both Alix and Rab27a, and significantly decreased nSMase2 levels.
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Neticonazole (1-100 ng/kg; oral gavage; daily; for 15 days; male C57BL/6 mice) treatment significantly improves the survival of intestinal dysbacteriosis (IDB) mice with colorectal cancer (CRC) xenograft tumors, likely through increasing apoptosis of CRC xenograft tumor cells.
Animal Model:
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Male C57BL/6 mice (8 weeks old) given ampicillin, neomycin, metronidazole and vancomycin, and injected with SW480 cells
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Dosage:
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1 ng/kg, 10 ng/kg and 100 ng/kg
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Administration:
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Oral gavage; daily; for 15 days
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Result:
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Significantly improved the survival of IDB mice with CRC xenograft tumors.
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盐酸奈替康唑
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/01/25 | HY-128365 | 盐酸奈替康唑 Neticonazole hydrochloride | 130773-02-3 | 25mg | 650元 |
2024/01/25 | HY-128365 | 盐酸奈替康唑 Neticonazole hydrochloride | 130773-02-3 | 50mg | 950元 |
130773-02-3, 盐酸奈替康唑 相关搜索:
- 药靶配体
- C17H23ClN2OS
- C17H22N2OSHCl
- (E)-1-(2-(甲硫基)-1-(2-(戊氧基)苯基)乙烯基)-1H-咪唑盐酸盐
- 盐酸萘康唑
- 盐酸奈康唑
- 盐酸奈替康唑
- 130773-02-3
- (E)-1-(2-(Methylthio)-1-(2-(pentyloxy)phenyl)vinyl)-1H-imidazole hydrochloride
- long-acting,colorectal,Neticonazole,antifungal,Neticonazole Hydrochloride,Imidazole,anti-cancer,nSMase2,Fungal,secretion,Inhibitor,p-ERK,anti-infection,inhibit,exosome
- 1-[(E)-2-methylsulfanyl-1-(2-pentoxyphenyl)ethenyl]imidazole,hydrochloride
- SS-717
- Neticonazole hydrochloride
- Atolant
- 1-[2-methylsulfanyl-1-(2-pentoxyphenyl)ethenyl]imidazole hydrochloride